[Human chorionic gonadotrophin regulates epidermal growth factor in the phallus of hypospadias mice].

Objective: To investigate the etiopathogenesis of congenital hypospadias and the regulating effect of exogenous human chorionic gonadotrophin (hCG) on the epidermal growth factor (EGF) in the phallus of hypospadiac mice.

Methods: Mouse models of congenital hypospadias were established. Fifty healthy male mice randomly selected as normal controls received intraperitoneal injection of normal saline, and another 50 with hypospadias were equally divided into an experimental control group, intraperitoneally injected with 1 ml normal saline, and 4 hCG dose groups treated by hCG intraperitoneal injection at 50 IU, 100 IU, 150 IU and 200 IU respectively for 7 consecutive days.

[Impact of the hCG on epidermal growth factor in the phallic tissues of hypospadiac mice].

Objective: To investigate the impact of hCG on the epidermal growth factor (EGF) in the phallic tissues of hypospadiac mice.

Methods: The Kunming mouse model of congenital hypospadias was established. As controls, 10 three-week-old normal male mice and 10 3-week-old congenital hypospadiac mice were injected with isometric sodium chloride intraperitoneally.