Publications by authors named "Xue-Bin Zou"
Article Synopsis
- The study evaluates the link between CEUS LI-RADS categories (LR 3-5 and LR-M) and survival outcomes in patients with early-stage hepatocellular carcinoma (HCC) post-treatment.
- It analyzed data from 272 high-risk HCC patients treated between 2010 and 2015, focusing on factors like recurrence-free survival (RFS) and overall survival (OS) until 2018.
- Results indicate that LR-M patients have poorer outcomes compared to LR 3-5 patients, with surgical resection offering better survival rates than radiofrequency ablation, highlighting the potential of CEUS LI-RADS to predict patient outcomes after initial HCC treatment.
Background: We assessed the surrogacy of objective response rate (ORR), disease control rate (DCR) and progression-free survival (PFS) for overall survival (OS) in anti-PD-1/PD-L1 trials of metastatic melanoma through a meta-analysis of randomized controlled trials (RCTs).
Methods: PubMed and EMBASE were searched for phase II/III RCTs till June 2019 investigating anti-PD-1/PD-L1 agents. Treatment effect (hazard ratio or odds ratio) on potential surrogates (ORR/DCR/PFS) and OS were collected.
Article Synopsis
- - The study evaluated if disease-free survival (DFS) could be a reliable predictor of overall survival (OS) in clinical trials for pancreatic cancer after surgical removal of the tumor.
- - Researchers reviewed 20 trials involving 5170 patients and found a strong correlation between the treatment effects on DFS and OS, confirming the reliability of DFS as a surrogate endpoint.
- - The analysis suggested that a DFS hazard ratio of 0.96 or less would indicate a positive treatment impact on OS in future pancreatic cancer adjuvant trials.
Background: Autophagy is a self-digesting process that can satisfy the metabolic needs of cells, and is closely related to development of cancer. However, the effect of autophagy-related genes (ARGs) on the prognosis of breast cancer remains unclear.
Results: We first found that 27 ARGs were significantly associated with overall survival in breast cancer.
Background Use of contrast material-enhanced (CE) US Liver Imaging Reporting and Data System (LI-RADS) version 2017 has not been validated in large populations where hepatitis B virus (HBV) is endemic. Purpose To evaluate the diagnostic performance of CE US LI-RADS version 2017 in a population with a high prevalence of HBV infection. Materials and Methods In this retrospective study, liver nodules in patients with HBV who were evaluated from January 2004 to December 2016 were categorized as CE US LR-1 to LR-5 through LR-M.
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- Postoperative radiotherapy (RT) after breast-conserving surgery (BCS) can improve survival rates for patients with stage T1-2N1 breast cancer compared to those who undergo mastectomy with RT.
- A study analyzed 1816 patients and found that BCS plus RT resulted in significantly lower rates of distant metastasis and better overall survival compared to mastectomy.
- The findings suggest that while RT benefits all patients post-surgery, it offers greater survival advantages for those undergoing BCS rather than mastectomy, particularly in terms of distant metastasis and cancer-specific survival.
Objective: Our objective was to examine whether adding induction chemotherapy to concurrent chemoradiotherapy improved survival in stage III nasopharyngeal carcinoma (NPC) patients, especially in low-risk patients at stage T3N0-1.
Materials And Methods: We retrospectively analyzed 687 patients with stage T3N0-1 NPC treated with intensity-modulated radiation therapy (IMRT) plus concurrent chemotherapy (CC) with or without induction chemotherapy (IC). Propensity score matching (PSM) method was used to select 237 pairs of patients from two cohorts.
Purpose: The value of adding induction chemotherapy to chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (LA-NPC) remains controversial, yet high-risk patients with LA-NPC have poor outcomes after chemoradiotherapy. We aimed to assess the survival benefits of induction chemotherapy in stage IVa-b NPC.
Patients And Methods: A total of 602 patients with stage IVa-b NPC treated with intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy with or without induction chemotherapy were retrospectively analyzed.