Rigidity Reinforcement of 3D Covalent Organic Frameworks by Controlling Interpenetration.

Here, we report the synthesis of a 3D covalent organic framework (COF), COF-308, with unique [4 + 2] interpenetration. Rather than inducing unwanted structure dynamics and a drastic drop in surface area, this interpenetration mode enhanced the structural rigidity and achieved a desirable surface area. Such an interpenetration was unveiled by single crystal X-ray diffraction (SCXRD) analysis with a resolution of 0.

ORANGE proteins mediate adaptation to high light and resistance to Pseudomonas syringae in tomato by regulating chlorophylls and carotenoids accumulation.

Chlorophylls and carotenoids are crucial for photosynthesis and plant survival, with ORANGE (OR) protein being pivotal in pigment accumulation. Despite tomato being rich in carotenoids, the roles of OR proteins in tomato have been overlooked. Herein, we characterized two OR genes in tomato, SlOR and SlOR-like, which are highly expressed in stems, leaves, and flowers, with their proteins being localized to chloroplasts.

Nomogram for predicting nutritional risk of cognitive impairment.

Background: Cognitive impairment patients are prone to malnutrition, which further promotes cognitive decline. Cognitive impairment patients are unable to accurately answer subjective questions in the nutrition screening scale. Therefore, it is crucial to establish a nutritional risk prediction model using objective evaluation indicators to evaluate the nutritional status of cognitive impairment patients during hospitalization.

Geriatric Nutritional Risk Index and In-Hospital Mortality and Costs in Older Inpatients With and Without Cancer: A Retrospective Observational Study.

Aims: To explore the association of the Geriatric Nutritional Risk Index (GNRI) with in-hospital mortality and costs in older inpatients and to compare these associations between cancer and non-cancer patients to inform clinical practice.

Design: Retrospective observational study.

Methods: A hospital-based study was conducted in Southwest China between January 2018 and December 2020.

Risk factors of diabetes in a high risk cardiovascular population in Hainan Province.

This study aimed to understand the influencing factors of diabetes among the cardiovascular high-risk population aged 35-75 in Hainan Province, in order to provide a reference basis for the development of scientific prevention strategies and intervention measures. From January 2016 to February 2023, a random sample of 71,819 residents aged 35-75 in Hainan Province was screened, identifying 12,936 cardiovascular high-risk individuals. All 2,908 diabetic patients were chosen as cases, with a 1:1 age- and gender-matched control group selected from the high-risk pool.

Microtubule-modulating drugs alter sensitivity to isoflurane in mice.

Background: Microtubules (MTs) have been postulated as one of the molecular targets underlying loss of consciousness induced by inhalational anesthetics. Microtubule-targeting chemotherapy drugs and opioids affect MT stability and function. However, the impact of prolonged administration of these drugs on anesthetic potency and anesthesia induction and emergence times remain unelucidated.

Exploring the Roles of the () Gene Family in Tomato ( L.) Under Abiotic Stresses.

PLATZ transcription factors represent a novel class of zinc finger proteins unique to plants and play critical roles in plant growth and stress responses. This study performs a bioinformatic analysis on the PLATZ transcription factor family in tomato. In the tomato genome, 20 PLATZ transcription factors were identified, distributed across nine chromosomes, including two tandem duplication clusters and two segmental duplication events.

Implantable photoelectrochemical-therapeutic methotrexate monitoring system with dual-atomic docking strategy.

The need for precise modulation of blood concentrations of pharmaceutical molecule, especially for high-risk drugs like Methotrexate (MTX), is underscored by the significant impact of individual variations on treatment efficacy. Achieving selective recognition of pharmaceutical molecules within the complex biological environment is a substantial challenge. To tackle this, we propose a synergistic atomic-molecular docking strategy that utilizes a hybrid-dual single-atom Fe1-Zn1 on a TiO2 photoelectrode to selectively bind to the carboxyl and aminopyrimidine groups of MTX respectively.

Mitsunobu reaction: assembling C-N bonds in chiral traditional Chinese medicine.

The synthesis of chiral molecules has long been a central focus and challenge in medicinal chemistry research. The Mitsunobu reaction, developed by Japanese chemist Mitsunobu in 1967, is a widely utilized bimolecular nucleophilic substitution reaction that plays a vital role in synthesizing chiral natural products. In this reaction, alcohols react with nucleophilic reagents in the presence of a phosphine ligand to form an intermediate phosphonium salt.

High-entropy oxide nanozyme for T/T dual-mode magnetic resonance imaging guided photothermal-nanocatalytic tumor therapy.

High-entropy oxides (HEOs) have attracted significant attention owing to their broad compositional tunability and high catalytic activity. However, research in this area is still in its early stages, and it is necessary to develop uniform multifunctional high-entropy nanozymes with appropriate sizes and excellent catalytic properties. In this study, we synthesized spherical high-entropy oxide composite carbon (HEO/C) nanoparticles (NPs) with a uniform distribution of particle size.

Predicting residual pain after vertebral augmentation in vertebral compression fractures: a systematic review and critical appraisal of risk prediction models.

Background: Patients with vertebral compression fractures may experience unpredictable residual pain following vertebral augmentation. Clinical prediction models have shown potential for early prevention and intervention of such residual pain. However, studies focusing on the quality and accuracy of these prediction models are lacking.

Evaluating the differences in healthy lifestyle behaviors between Chinese urban and rural residency after the termination of social distancing: analysis based on propensity score matching.

Background: During the COVID-19 pandemic, the social distancing has significantly affected the healthy lifestyle behaviors of residents. China ended social distancing on January 8, 2023, and the healthy lifestyle behaviors of residents after this time are unclear. The goal of this study was to evaluate the differences in healthy lifestyle behaviors between Chinese urban and rural residency after the termination of social distancing.

Simultaneous determination of naphthalimide-labelled monosaccharides in . Hua. polysaccharides utilizing the HPLC-UV technique.

4-Amidogen-1,8-naphthalimide (ANA), a novel pre-column derivatization reagent, has been successfully synthesized and utilized for the highly sensitive analysis of monosaccharides. ANA reacts with the reducing carbonyl groups of saccharides, facilitating monosaccharide detection. The resulting monosaccharide derivatives were meticulously investigated using High-Performance Liquid Chromatography (HPLC) coupled with ultraviolet (UV) spectroscopy.

DNMT3A loss drives a HIF-1-dependent synthetic lethality to HDAC6 inhibition in non-small cell lung cancer.

encodes a DNA methyltransferase involved in development, cell differentiation, and gene transcription, which is mutated and aberrant-expressed in cancers. Here, we revealed that loss of promotes malignant phenotypes in lung cancer. Based on the epigenetic inhibitor library synthetic lethal screening, we found that small-molecule HDAC6 inhibitors selectively killed -defective NSCLC cells.

Oral multistage nanomedicine for synergistic chemo/chemodynamic/near-infrared-II photothermal cancer therapy.

The oral administration of drugs for cancer therapy can maintain optimal blood concentrations, is biologically safe and simple, and is preferred by many patients. However, the complex lumen environment, mucus layer, and intestinal epithelial cells are biological barriers that hinder the absorption of orally administered drugs. In this study, sea urchin-like manganese-doped copper selenide nanoparticles (Mn-CuSe NPs) were designed using an anion exchange method and coated with calcium alginate and chitosan (AC) to form Mn-CuSe@AC capsules.

A Nomogram Model for Predicting Recurrent Coronary Thrombosis in Kawasaki Disease Patients.

Background: Coronary thrombosis is a serious cardiovascular complication of Kawasaki disease (KD), and recurrence of coronary thrombosis increases the short-term risk of myocardial infarction and the long-term risk of coronary artery disease. However, there are currently no studies predicting the recurrence of coronary thrombosis, so the aim of this study was to develop and validate a nomogram to predict recurrent coronary thrombosis in KD patients.

Methods: This was a retrospective study of data from 149 KD patients who had a history of previous coronary disease at the Children's Hospital of Chongqing Medical University from 2013 to 2020.

Construction of magnetic response nanocellulose particles to realize smart antibacterial of Pickering emulsion.

Smart antibacterial Pickering emulsion can respond to the stimulation of environmental conditions to control the release of antibacterial agents, protecting the quality and safety of food. In this study, FeO was grafted on the cellulose nanocrystal (CNC) via ultrasound-assisted in situ co-precipitation to synthesize the magnetic cellulose nanocomposite particles. When the ratio of FeCl and FeCl was 1.

Magnetic Nanocarriers for pH/GSH/NIR Triple-Responsive Drug Release and Synergistic Therapy in Tumor Cells.

In this study, the mesoporous FeO nanodrug carriers containing disulfide bonds (CHO-SMNPs) were successfully synthesized and characterized. Doxorubicin (DOX) was loaded onto the CHO-SMNPs as a model drug and gatekeeper through the formation of imine bonds with the aldehyde groups on the surface of the mesoporous materials. This drug carrier demonstrates effective drug release triggered by pH, glutathione (GSH), and near-infrared (NIR) light, along with satisfactory photothermal conversion efficiency under NIR irradiation at 808 nm.

Oxygen-Independent Photodynamic Therapy-Mediated Selective Consumption of M1 Macrophage Against Ventricular Arrhythmias via Sympathetic Neuromodulation.

The occurrence of myocardial infarction (MI)-induced malignant ventricular arrhythmias (VAs) is closely associated with the hyperactivation of left stellate ganglion (LSG). Proinflammatory M1 macrophage is reported to aggravate sympathetic overactivation and cause VAs. Therefore, the depletion of M1 macrophage is anticipated to inhibit LSG overactivation and alleviate MI-induced VAs.

Surfactant-free CuPt nano-alloys with controllable atomic ratios and their enhanced electrocatalytic activity.

The electrocatalytic mechanisms of electrocatalysts were constrained by the disparities between the genuine catalytic interface and construction interface. This work demonstrated the relationship between the CuPt nano-alloy atomic ratios and their catalytic performance. Firstly, we developed a facile synthesis of surfactant-free CuPt nano-alloys with tunable Cu atomic ratios (ranging from 35 to 72 at%) under ambient conditions.

Epidemiological characteristics of eleven common respiratory viral infections in children.

Background: Lower respiratory tract infections (LRTIs) are one of the leading causes of hospital admissions among children. In this study, we aimed to describe the epidemiological characteristics of viral pathogens associated with LRTIs in hospitalized children in Yan'an; this has yet to be reported in the literature and may guide public health interventions and resource allocation in this region.

Methods: Between June 2021 and May 2023, we conducted a retrospective analysis of the results of viral detection using oral pharyngeal swabs from 4565 children with LRTIs in the Inpatient Department of Yan'an University Affiliated Hospital.

Hydrodynamic moiré superlattice.

The structural periodicity in photonic crystals guarantees the crystal's effective energy band structure, which is the fundamental cornerstone of topological and moiré physics. However, the shear modulus in most fluids is close to zero, which makes it challenging for fluids to maintain spatial periodicity akin to photonic crystals. We realized periodic vortices in hydrodynamic metamaterials and created a bilayer moiré superlattice by stacking and twisting two such vortex fluids.

Effects of Heart Rate Fluctuation on Aerobic Training Outcomes in Patients With Stable Coronary Artery Disease: A Prospective Study.

Background: This study aimed to evaluate the effects of different heart rate fluctuation ranges during aerobic training on outcomes in patients with stable coronary artery disease (CAD).

Methods: Ninety-seven patients diagnosed with stable CAD were enrolled between March 2017 and December 2019. Participants were randomly assigned to three groups: the control (CON) group, the medium-intensity heart rate small range (MIS) group, and the medium-intensity heart rate large range (MIL) group.

Unveiling Active Al Sites for Ethanol Dehydration on γ-AlO with Solid-State Nuclear Magnetic Resonance Spectroscopy.

γ-AlO is a crucial catalyst widely used in industrial alcohol dehydration processes. However, the specific nature of its active sites has remained unclear. In this study, we utilize two-dimensional heteronuclear correlation solid-state nuclear magnetic resonance and density functional theory calculations to uncover the active Al sites on the surface of γ-AlO that facilitate ethanol dehydration.

Epoxy metabolites of linoleic acid promote the development of breast cancer via orchestrating PLEC/NFκB1/CXCL9-mediated tumor growth and metastasis.

Breast cancer (BC) is a common malignant tumor in women and requires a comprehensive understanding of its pathogenesis for the development of new therapeutic strategies. Polyunsaturated fatty acids (PUFAs) metabolism-driven inflammation is a causative factor in cancer development. However, the function of PUFAs' metabolism in BC remains largely unknown.