Comparative study of antifungal susceptibility testing methods for clinical Candida albicans isolates.

Purpose: Candida albicans is the second most common cause of candidemia in Malaysia. The Clinical and Laboratory Standards Institute (CLSI) broth microdilution method is the gold standard for determining its minimum inhibitory concentration (MIC); however, it is laborious and time-consuming. This study was conducted to evaluate the usefulness of alternative methods, namely Sensititre YeastOne (SYO), VITEK 2 system, and E-test for determining the MIC of clinical C.

Antifungal Susceptibility and Genotypic Analysis of Mutations in Isolates in Malaysia.

Purpose: Azole resistance in poses a significant challenge in the management of invasive aspergillosis. This study aimed to investigate the antifungal susceptibility and mutation profiles of isolates in Malaysia.

Patients And Methods: Sixty clinical isolates were collected and subjected to antifungal susceptibility testing (AFST) and molecular analysis.

Comparison of in vitro Susceptibilities of in Mold and Yeast Forms in Malaysia.

Purpose: This study was aimed to determine minimum inhibitory concentration (MIC) differences between yeast and mold forms of in Malaysia.

Patients And Methods: Ninety-seven clinical strains of were received from various Malaysian hospitals from the year 2020 until 2022. Their identities were determined using microscopic, macroscopic and molecular methods.

Mucosal Sporotrichosis from Zoonotic Transmission: Descriptions of Four Case Reports.

Background: Sporotrichosis is a subacute or chronic mycosis caused by a dimorphic fungus of the genus . Zoonotic-transmitted sporotrichosis has become a major public health concern and is characterised by a different clinical pattern from the traditional epidemiology of sporotrichosis.

Case Presentation: We present the details of four patients with mucosal sporotrichosis with regional lymphadenopathy (three cases of granulomatous conjunctivitis and one case of nasal sporotrichosis).

Potential serum biomarkers associated with mild and severe leptospirosis infection: A cohort study in the Malaysian population.

Leptospirosis is an emerging zoonotic infectious disease in Malaysia. The symptoms of leptospirosis vary from mild nonspecific flu-like illness to a severe condition which is usually associated with serious complication and fatality. To study the protein expression profile of mild and severe leptospirosis, 15 paired sera were collected from the patients who were mildly infected and following that progressed to severe stage.

In-house ELISA screening using a locally-isolated Leptospira in Malaysia: determination of its cut-off points.

Background: Leptospirosis is a zoonotic disease caused by Leptospira species and is distributed globally. Microscopic agglutination test (MAT) is the serological 'gold standard' for diagnosis of leptospirosis but it is time-consuming and labour-intensive. An alternative serological method that is rapid, sensitive and specific is important for early treatment to reduce morbidity and mortality.