Malignant Extrarenal Rhabdoid tumor derived from the greater omentum: A case report and literature review.

Background: Malignant extrarenal rhabdoid tumor (MERT) is a rare and highly metastatic tumor, which is more than 75% of patients dying within 6 months of initial diagnosis, and it often leads to misdiagnosis and delayed treatment.

Case: This paper reports a 16-year-old girl who presented with the chief complaint of acute abdominal pain. She underwent laparoscopic exploration and excisional biopsy, then pathological examination and immunohistochemistry revealed "extrarenal malignant rhabdomyoma.

Rational treatment options for T1/2N0M0 squamous cell carcinoma of the anal canal: a population-based study combined with external validation.

Background: Treatment options for T1/2N0M0 anal squamous cell carcinoma include chemotherapy, radiotherapy, chemoradiotherapy, and local excision, although the optimal treatment method has not been determined.

Methods: The National Cancer Institute Surveillance, Epidemiology and Results database was used to search and screen 1465 patients with cT1/2N0M0 anal squamous cell carcinoma who were clinically diagnosed between 2004 and 2016. Survival analysis was performed using the Kaplan-Meier method and log-rank test.

polysaccharides suppress excessive melanogenesis via JNK-mediated pathway: Investigation in 8- methoxypsoralen induced B16-F10 melanoma cells and clinical study.

Skin hyperpigmentation is a worldwide condition associated with augmented melanogenesis. However, conventional therapies often entail various adverse effects. Here, we explore the safety range and depigmentary effects of polysaccharides extract of (PETM) in an model and further evaluated its efficacy at the clinical level.

Tributyltin-induced oxidative stress causes developmental damage in the cardiovascular system of zebrafish (Danio rerio).

Tributyltin (TBT) can be used as an antifouling agent with anticorrosive, antiseptic and antifungal properties and is widely used in wood preservation and ship painting. However, it has recently been found that TBT can be harmful to aquatic organisms. In this study, to gain insight into the effects of TBT with respect to the development of the cardiovascular system in zebrafish embryos, zebrafish embryos were exposed to different concentrations of TBT solutions (0.

Rhizoma Paridis saponins attenuate Gram-negative bacteria-induced inflammatory acne by binding to KEAP1 and modulating Nrf2 and MAPK pathways.

Acne vulgaris represents a chronic inflammatory condition, the pathogenesis of which is closely associated with the altered skin microbiome. Recent studies have implicated a profound role of Gram-negative bacteria in acne development, but there is a lack of antiacne agents targeting these bacteria. Polyphyllins are major components of Rhizoma Paridis with great anti-inflammatory potential.

Disease Burden and Epidemiological Trends of Chronic Kidney Disease at the Global, Regional, National Levels from 1990 to 2019.

Background: Chronic kidney disease (CKD) is a serious public health issue worldwide, but the disease burden of CKD caused by different etiologies and changing trends has not been fully examined.

Methods: We collected data from Global Burden of Disease Study 2019 (GBD 2019), including incident cases, age-standardized incidence rate (ASIR), disability-adjusted life years (DALYs), and age-standardized DALY rate between 1990 and 2019 by region, etiology, age, and sex, and calculated the estimated annual percentage change (EAPC) of the rate to evaluate the epidemiological trends.

Results: Globally, incident cases of CKD increased from 7.

Pullulan-stabilized Soybean Phospholipids/Cinnamaldehyde emulsion for Flammulina velutipes preservation.

Fresh mushrooms (Flammulina velutipes) are very perishable and easily brown; also they undergo postharvest loss of nutritive constituents. In this study, cinnamaldehyde (CA) emulsion was prepared by using soybean phospholipids (SP) as emulsifier and pullulan (Pul) as stabilizer. The effect of emulsion on the quality of mushroom during storage was also studied.

Dopamine modified layered double hydroxide membranes based on nanofibril architectures: Toward superior tellurium separation properties for water treatment.

Two-dimensional (2D) membrane materials are widely employed for the accurate sieving of ionic contaminants and are of great importance for water reuse. However, 2D membrane materials often suffer from uneven thickness and surface defects, which severely limit their application prospects. Herein, a continuous 2D membrane (LCUM/D) was prepared using cellulose nanofibrils (CNFs) as the support backbone for the assembled layered double hydroxides (LDHs) and dopamine (DA) as the adhesive.

Clinicopathologic factors linked to oncologic outcomes for renal cell carcinoma with sarcomatoid dedifferentiation: A PRISMA-compliant systematic review and meta-analysis.

Background: There are still differences in the prognostic factors of renal cell carcinoma with sarcomatoid dedifferentiation (sRCC). The aim of this study was to evaluate important predictors of survival in patients with sRCC.

Patients And Methods: A comprehensive search of PubMed, Embase, and Cochrane Library was conducted to identify eligible studies.

Directional Construction of Active Naphthalenic Species within SAPO-34 Crystals toward More Efficient Methanol-to-Olefin Conversion.

Olefin selectivity and catalyst lifetime are two key metrics for industrial methanol-to-olefin catalysts. Currently, it is very difficult to obtain high olefin selectivity and long catalyst lifetime at the same time. Herein, a feasible strategy combining precoking and steaming to directionally construct the active naphthalenic species within the crystal center of the SAPO-34 catalyst has been developed, which can not only promote the lower olefin selectivity to ∼89% (ethylene and propylene) but also prolong the catalyst lifetime by ∼3.

Latent, Early or Late Human Herpes Virus-6B Expression in Adult Mesial Temporal Lobe Epilepsy: Association of Virus Life Cycle with Inflammatory Cytokines in Brain Tissue and Cerebral Spinal Fluid.

Background: Human herpes virus-6B (HHV-6B) was suggested as an important etiologic factor of mesial temporal lobe epilepsy, while the mechanism is still unknown. Here, we aimed to analyze antigens representing latent, early and late HHV-6B infection and the association with inflammatory cytokines in brain tissue and cerebral spinal fluid (CSF) from MTLE patients with HHV-6B-positivity.

Methods: Nested polymerase chain reaction (nPCR), real-time PCR, immunohistochemistry (IHC) and suspension bead array for cytokines were performed.

The change rate in serum nitric oxide may affect lenvatinib therapy in hepatocellular carcinoma.

Background: Lenvatinib is appropriate for reducing the production of nitric oxide (NO) and facilitating as block angiogenesis. However, to our knowledge, there are no data that support the correlation between NO and clinical response in patients who received lenvatinib therapy for HCC. Therefore, we investigated the correlation between the change rate of NO levels and clinical responses including adverse events (AEs) after lenvatinib therapy for unresectable hepatocellular carcinoma (HCC).

Serum Metabolomics Benefits Discrimination Kidney Disease Development in Type 2 Diabetes Patients.

Background: Diabetic kidney disease (DKD) is the primary cause of end-stage renal disease, raising a considerable burden worldwide. Recognizing novel biomarkers by metabolomics can shed light on new biochemical insight to benefit DKD diagnostics and therapeutics. We hypothesized that serum metabolites can serve as biomarkers in the progression of DKD.

CoS grafted 1 T-phase dominated WS ultrathin nanosheet arrays for highly efficient overall water splitting in alkaline media.

Developing the earth-abundant transition metal-based bifunctional electrocatalysts for water splitting and renewable energy devices has attracted much attention. Herein, we report a 1 T-WS in ultrathin nanosheet arrays grafted with CoS on conductive carbon cloth (CC) (1 T-CoS-WS/CC) through a feasible in-situ growth and vulcanization. The optimized 1 T-CoS-WS/CC catalyst exhibits an impressive electrocatalytic activity and remarkable stability with the oxygen/hydrogen evolution reaction (OER/HER: 278/75 mV for 10 mA cm).

The Risk of Cirrhosis and Its Complications Based on PNPLA3 rs738409 G Allele Frequency.

Background: Data regarding the influence of patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism for patients with liver cirrhosis (LC) are scarce.

Objective: This study assesses the role of the PNPLA3 polymorphism for the development of LC and its complications by the findings of genetic examinations.

Methods: Patients with LC caused by virus (n = 157), alcohol (n = 104), nonalcoholic fatty liver disease (NAFLD) (n = 106), or autoimmune disease (n = 33) and without LC (n = 128) were enrolled.

Oxygen vacancy-rich N-doped carbon encapsulated BiOCl-CNTs heterostructures as robust electrocatalyst synergistically promote oxygen reduction and Zn-air batteries.

The development of non-precious metal catalysts for oxygen reduction reactions (ORR) is vital for promising clean energy technologies such as fuel cells, and zinc-air batteries. Herein, we present a stepwise synthesis of N-doped and carbon encapsulated BiOCl-CNTs heterostructures. Electrocatalytic ORR studies show that the optimized catalyst has a high half-wave potential (E) of 0.

Construction of lignin-based nano-adsorbents for efficient and selective recovery of tellurium (IV) from wastewater.

Tellurium is massively used as the main light-absorbing layer component in the manufacturing of CdTe thin-film solar cells, a critical component in the photovoltaic industry. However, the process of manufacturing and renewing components has produced large amounts of tellurium-containing wastewater that is difficult to degrade and poses a serious threat to the aquatic ecosystem and human health. Hence, to achieve the recovery of tellurium resources for reducing their damages, a win-win approach was employed to utilize waste lignin to construct functional copper-doped activated lignin (CAL) adsorbents for selective separation and recovery of tellurium from wastewater.

Additional L-Carnitine Reduced the Risk of Hospitalization in Patients with Overt Hepatic Encephalopathy on Rifaximin.

Background: Data regarding the additional effect on the recurrence of hepatic encephalopathy (HE) after oral L-carnitine administration are scarce.

Objective: This study aimed to assess the additional effects of L-carnitine in patients who were receiving rifaximin for HE.

Methods: This randomized study comprised a screening visit and a 12-week treatment period.

Interfacial Electronic Coupling of NC@WO -W C Decorated Ru Clusters as a Reversible Catalyst toward Electrocatalytic Hydrogen Oxidation and Evolution Reactions.

Designing a bifunctional catalyst for hydrogen oxidation reaction (HOR) and hydrogen evolution reaction (HER) is significant toward developing sustainable hydrogen-electric conversion systems. Herein, a cost-effective bifunctional catalyst, Ru/N-doped Carbon@WO -W C (Ru/NC@WOC), was developed via co-precipitation and polyol reduction. Ru/NC@WOC showed superior HOR/HER activity in alkaline solution in comparison with commercial Pt/C.

LINC00176 facilitates CD4T cell adhesion in systemic lupus erythematosus via the WNT5a signaling pathway by regulating WIF1.

Accruing research shows the implications of long non-coding RNAs (lncRNAs) in the progression of various autoimmune diseases including systemic lupus erythematosus (SLE). The present study aimed to identify the expression pattern of LINC00176 in SLE and to explore its effects on CD4T cell adhesion in this context. The biological functions of LINC00176, WIF1 and WNT5a on CD4T cells in SLE were evaluated via gain- and loss-of-function experiments, following delivery of pcDNA3-LINC00176, siRNA-LINC00176, pcDNA3-WIF1 and WNT-sFRP5 (an inhibitor for the WNT5a signaling pathway).

Comparison of Outcomes Between Transperitoneal and Retroperitoneal Robotic Partial Nephrectomy: A Meta-Analysis Based on Comparative Studies.

Background: To compare perioperative, functional and oncological outcomes between transperitoneal robotic partial nephrectomy (TRPN) and retroperitoneal robotic partial nephrectomy (RRPN).

Methods: A literature searching of Pubmed, Embase, Cochrane Library and Web of Science was performed in August, 2020. Pooled odds ratios (ORs) or weighted mean differences (WMDs) with 95% confidence intervals (CIs) were estimated using fixed-effect or random-effect model.

Influence of NOS3 rs2070744 genotypes on hepatocellular carcinoma patients treated with lenvatinib.

We investigated whether or not nitric oxide synthase 3 (NOS3) rs2070744 genotypes can affect the response for lenvatinib treatment in patients with hepatocellular carcinoma (HCC). We evaluated the relation of the NOS3 rs2070744 genotypes to the tumor response, progression-free survival (PFS), and overall survival (OS) as the response for lenvatinib. We also examined the association between fibroblast growth factor receptor (FGFR) gene polymorphisms, a potential feature of lenvatinib, and the response.

Long-term observation in patients with esophageal varices after endoscopic variceal ligation accompanied with 24-hour pH monitoring.

Aim: Esophageal variceal ligation (EVL) is usually carried out to decrease the risk of hemorrhage. Several complications have been reported with the procedure, including bleeding from ligation-induced esophageal ulcers or heartburn. However, there is scant evidence for gastroesophageal reflux caused by EVL.

Impact of Anti-GPIIb/IIIa Antibody-Producing B Cells as a Predictor of the Response to Lusutrombopag in Thrombocytopenic Patients with Liver Disease.

Background: To make an accurate estimate of the response to thrombopoietin (TPO) receptor agonists for thrombocytopenia associated with chronic liver disease, we evaluated the influence of antiplatelet autoantibodies on the response to lusutrombopag in thrombocytopenic patients with liver disease.

Methods: A prospective study was conducted at 2 hospitals. Thrombocytopenic patients with liver disease received oral lusutrombopag 3.