New Contributions on Species Diversity of Genus and s.l. in China.

Southwest China is extremely rich in fungal resources, and a large number of new taxa have been discovered in recent years. In the present study, we examined 26 specimens of the genera and sensu lato, most of which were obtained in Yunnan Province. Through ITS-nrLSU- phylogenetic analysis, combined with morphological studies and geographic analyses, five new species were described, viz.

An explainable predictive model for anxiety symptoms risk among Chinese older adults with abdominal obesity using a machine learning and SHapley Additive exPlanations approach.

Background: Early detection of anxiety symptoms can support early intervention and may help reduce the burden of disease in later life in the elderly with abdominal obesity, thereby increasing the chances of healthy aging. The objective of this research is to formulate and validate a predictive model that forecasts the probability of developing anxiety symptoms in elderly Chinese individuals with abdominal obesity.

Method: This research's model development and internal validation encompassed 2,427 participants from the 2017-2018 Study of the Chinese Longitudinal Healthy Longevity Survey (CLHLS).

Pharmacokinetics and metabolism of ketoconazole after single ocular instillation in Sprague-Dawley rats.

Background And Purpose: Ketoconazole is limited to its conditioned oral use due to hepatic toxicity. Its ocular eye drop administration may be an option for mycotic keratitis treatment. Therefore, it is necessary to explore its pharmacokinetic and metabolic profile via topical ocular administration.

Deep Learning-Enabled Rapid Metabolic Decoding of Small Extracellular Vesicles via Dual-Use Mass Spectroscopy Chip Array.

The increasing focus of small extracellular vesicles (sEVs) in liquid biopsy has created a significant demand for streamlined improvements in sEV isolation methods, efficient collection of high-quality sEV data, and powerful rapid analysis of large data sets. Herein, we develop a high-throughput dual-use mass spectroscopic chip array (DUMSCA) for the rapid isolation and detection of plasma sEVs. The DUMSCA realizes more than a 50% increase in speed compared to traditional method and confirms proficiency in robust storage, reuse, high-efficiency desorption/ionization, and metabolite quantification.

Cavitation dynamics and thermodynamic effect of R134a refrigerant in a Venturi tube.

Cavitation plays a crucial role in the reliability of components in refrigeration systems. The properties of refrigerants change significantly with temperature, thereby amplifying the impact of thermodynamic effects. This study, based on the Large Eddy Simulation (LES) method and the Schnerr-Sauer (S-S) cavitation model, investigates the transient cavitating flow characteristics of the R134a refrigerant in a Venturi tube (VT).

Triple-mode sensing platform for acetylcholinesterase activity monitoring and anti-Alzheimer's drug screening based on a highly stable Cu (I) compound.

Acetylcholinesterase (AChE) and AChE inhibitors play critical roles in the early diagnosis and treatment of Alzheimer's disease (AD). Herein, a fluorescence/colorimetry/smartphone triple-mode sensing platform was constructed for both AChE activity monitoring and AChE inhibitor screening by exploring a Cu (I) compound, CuI (SR) (R = CHCHNH), as a fluorescent probe. In comparison of most other fluorescent probes, CuI (SR) presented exceptional stability against pH, temperature, UV irradiation, redox agents, and metal ions, as well as good recyclability due to its unique chemical structure.

Cloning the promoter of the sucrose transporter gene PsSUT2 and screening its upstream transcription factors in tree peony.

Sucrose is an essential energy substance for tree peony (Paeonia Suffruticosa) floral organ development. However, little is known about the sucrose regulatory network in tree peony. In this study, the promoter sequence of the tree peony sucrose transporter gene PsSUT2 was cloned.

Consuming probiotics protects against cadmium exposure from rice consumption while promotes gut health: An assessment based on a mouse model.

Cadmium (Cd) in rice constitutes a global health risk. It is crucial to develop strategies that not only reduce the bioavailability of Cd in rice but also confer additional health benefits. One potential approach involves the consumption of probiotics, which can bind Cd in the intestines and enhance gut health.

DropNaE: Alleviating irregularity for large-scale graph representation learning.

Large-scale graphs are prevalent in various real-world scenarios and can be effectively processed using Graph Neural Networks (GNNs) on GPUs to derive meaningful representations. However, the inherent irregularity found in real-world graphs poses challenges for leveraging the single-instruction multiple-data execution mode of GPUs, leading to inefficiencies in GNN training. In this paper, we try to alleviate this irregularity at its origin-the irregular graph data itself.

Relaxation-exchange magnetic resonance imaging (REXI): a non-invasive imaging method for evaluating trans-barrier water exchange in the choroid plexus.

Background: The choroid plexus (CP) plays a crucial role in cerebrospinal fluid (CSF) production and brain homeostasis. However, non-invasive imaging techniques to assess its function remain limited. This study was conducted to develop a novel, contrast-agent-free MRI technique, termed relaxation-exchange magnetic resonance imaging (REXI), for evaluating CP-CSF water transport, a potential biomarker of CP function.

Longitudinal association of urbanization and risk of myocardial infarction in China: an analysis from the China Health and Nutrition Survey.

Background: The association between urbanization and myocardial infarction in China was not fully understood. We aim to evaluate the association between urbanization level and the risk of myocardial infarction.

Methods: Participants' data from China Health and Nutrition Survey were analyzed.

Comparison of remimazolam and propofol on postoperative subjective quality of recovery in patients undergoing general anesthesia: a meta-analysis of randomized controlled trials.

Introduction: Remimazolam, a recently approved drug for surgical sedation and general anesthesia, has been compared with propofol in previous studies regarding its efficacy as a general anesthetic. However, the question of whether remimazolam demonstrates non-inferiority to propofol in postoperative subjective quality of recovery (QoR) among patients under general anesthesia has not been definitively answered.

Evidence Acquisition: PubMed, Embase, and Cochrane Library databases were systematically searched for all published randomized controlled trials (RCTs) comparing the efficacy of remimazolam and propofol.

Two-step biocatalytic conversion of post-consumer polyethylene terephthalate into value-added products facilitated by genetic and bioprocess engineering.

Solving the plastic crisis requires high recycling quotas and technologies that allow open loop recycling. Here a biological plastic valorization approach consisting of tandem enzymatic hydrolysis and monomer conversion of post-consumer polyethylene terephthalate into value-added products is presented. Hydrolysates obtained from enzymatic degradation of pre-treated post-consumer polyethylene terephthalate bottles in a stirred-tank reactor served as the carbon source for a batch fermentation with an engineered Pseudomonas putida strain to produce 90mg/L of the biopolymer cyanophycin.

The ethanolic extract of var. flowers ameliorates depressive-like behaviors of mice by modulating the serotonin system and suppressing neuroinflammation.

It is crucial to explore the impact of dietary interventions on depression and develop functional antidepressant foods, due to the significant side effects and poor treatment compliance of antidepressant drugs. flowers are edible and medicinal materials owing to their delightful floral aroma and significant health benefits. Here, we evaluated the antidepressant effects of the ethanolic extract of var.

Eye of the future: Unlocking the potential utilization of hydrogels in intraocular lenses.

Hydrogels are distinguished by their exceptional ability to absorb and retain large volumes of water within their complex three-dimensional polymer networks, which is advantageous for the development of intraocular lenses (IOLs). Their innate hydrophilicity offers an optimal substrate for the fabrication of IOLs that simulate the natural lens' accommodation, thereby reducing irritation and facilitating healing after surgery. The swelling and water retention characteristics of hydrogels contribute to their notable biocompatibility and versatile mechanical properties.

Polarization: A Universal Driving Force for Energy, Environment, and Electronics.

The sustainable future relies on the synergistic development of energy, environmental, and electronic systems, founded on the development of functional materials by exploring their quantum mechanisms. Effective control over the distribution and behavior of charges within these materials, a basic quantum attribute, is crucial in dictating their physical, chemical, and electronic properties. At the core of charge manipulation lies "polarization"-a ubiquitous phenomenon marked by separating positive and negative charges.

Accelerated biological aging and risk of atrial fibrillation: A cohort study.

Background: Even though aging has been demonstrated to be associated with a higher risk of atrial fibrillation (AF), it is unclear whether biological aging is associated with risk of incident AF.

Objective: This study aimed to investigate the association between biological aging and AF.

Methods: A total of 371,882 participants without AF at baseline from the UK Biobank were included.

Response of dissolved organic matter and disinfection by-product precursors to algal blooms and thermal stratification in deep reservoirs.

Algal bloom contribute substantially to dissolved organic matter (DOM) and disinfection by-product (DBP) precursors in deep reservoirs, threatening drinking water safety. However, the variations in DOM and DBP precursors in deep-water reservoirs during algal bloom remain unclear. UV and fluorescence spectroscopy and chlorination experiments were used to analyze the variations in DOM and DBP precursors during algal bloom in the Sanhekou Reservoir.

Compact highly sensitive photothermal RT-LAMP chip for simultaneous multidisease detection.

Developing instant detection systems with disease diagnostic capabilities holds immense importance for remote or resource-limited areas. However, the task of creating these systems-which are simultaneously easy to operate, rapid in detection, and cost-effective-remains a challenge. In this study, we present a compact highly sensitive photothermal reverse transcriptase-loop-mediated isothermal amplification (RT-LAMP) chip (SPRC) designed for the detection of multiple diseases.