Prediction and analysis of the tumor invasiveness of pulmonary ground-glass nodules based on metabolomics.

In recent years, the incidence of ground-glass nodular lung adenocarcinoma has gradually increased. Preoperative evaluation of the tumor invasiveness is very important, but there is a lack of effective methods. Plasma samples of ground-glass nodular lung adenocarcinoma and healthy volunteers were collected.

Genetic Ablation of p16 Mitigates Premature Osteoporosis Induced by PTHrP Nuclear Localization Sequence and C-terminal Deletion through Inhibition of Cellular Senescence.

Premature osteoporosis due to parathyroid hormone-related peptide (PTHrP) dysfunction presents significant bone health challenges. This study explores the role of p16-mediated cellular senescence in this condition using a Pthrp knock-in (KI) mouse model lacking the nuclear localization sequence and C-terminus of PTHrP. We generated p16⁻⁄⁻KI mice and compared them with wild-type, p16⁻⁄⁻, and KI mice.

CT Radiomic Nomogram Using Optimal Volume of Interest for Preoperatively Predicting Invasive Mucinous Adenocarcinomas in Patients with Incidental Pulmonary Nodules: A Multicenter, Large-Scale Study.

Introduction: This study evaluated the efficacy of radiomic analysis with optimal volumes of interest (VOIs) on computed tomography images to preoperatively differentiate invasive mucinous adenocarcinoma (IMA) from non-mucinous adenocarcinoma (non-IMA) in patients with incidental pulmonary nodules (IPNs).

Methods: This multicenter, large-scale retrospective study included 1383 patients with IPNs, 110 (8%) of whom were pathologically diagnosed with IMA postoperatively. Radiomic features were extracted from multi-scale VOI subgroups (VOI, VOI, VOI , and VOI ).

Efficacy and dispensing patterns of TCM-acupuncture combinations in vascular dementia treatment: a meta-analysis and data mining analysis.

Objectives: To evaluate the clinical efficacy of the combination of acupuncture and medicine for vascular dementia (VD) treatment, and to analyze and summarize the relevant association rules.

Methods: A systematic search of Chinese and English databases such as CNKI, VIP, Wanfang, Embase, PubMed, Cochrane Library, and Web of Science was performed along with a manual search to screen for randomized controlled trials that met the inclusion and exclusion criteria that were published over a period from January 1, 2000, to July 31, 2023. Literature quality assessment and meta-analysis were performed using the and RevMan 5.

Outcomes of Intraoperative Radiotherapy for Locally Advanced Adenocarcinoma of the Esophagogastric Junction After Neoadjuvant Therapy: A Single-Arm, Phase 1 Trial From the Chinese National Cancer Center.

Background: The role of intraoperative radiotherapy (IORT) for adenocarcinoma of the esophagogastric junction (AEG) remains uncertain. Therefore, a prospective phase 1 trial was conducted to assess the safety and feasibility of IORT for locally advanced AEG.

Methods: The study enrolled patients with AEG at stages II-IVA from January 2019 to September 2019.

Footprint of soil erosion effects on pedodiversity at different hierarchical levels: A study across China's water erosion-prone areas.

Pedodiversity conservation is critical for the sustainable use of soil resources and the regulation of ecological security. To explore the relationship between pedodiversity and soil erosion over a prolonged history. In this paper, the response of the regional measurement factor for erosion (RMFE) to pedodiversity at different hierarchical levels was investigated using the optimal window method and structural equation modeling on the basis of water erosion-prone zones.

Radiomics Nomogram Based on Optimal Volume of Interest Derived from High-Resolution CT for Preoperative Prediction of IASLC Grading in Clinical IA Lung Adenocarcinomas: A Multi-Center, Large-Population Study.

The novel grading system developed by the International Association for the Study of Lung Cancer (IASLC) for clinical stage IA lung adenocarcinomas has demonstrated remarkable prognostic capabilities. Notably, tumors classified as grade 3 have been associated with poor prognostic outcomes, thereby playing a crucial role in the formulation of personalized surgical strategies. The objective of this study is to develop a radiomics nomogram that utilizes the optimal volume of interest (VOI) derived from high-resolution CT (HRCT) scans to accurately predict the presence of grade 3 tumors in patients with clinical IA lung adenocarcinomas.

Research on TNTON/DNTF eutectic characteristics: an exploration of low eutectic mixture based melt-cast explosive carriers.

To modify the sensitivity and melting point of the casting of DNTF, a eutectic system of insensitive explosive 3,5,5-trinitro-1,3-oxazinane (TNTON) and DNTF was prepared through a new method. The melting and liquefaction processes of TNTON/DNTF at different ratios were investigated, and a phase diagram was established. The melting and decomposition processes of TNTON, DNTF, and TNTON/DNTF eutectic at different heating rates were compared, while the sensitivity tests were conducted to study the desensitizing effect of TNTON on DNTF.

Modified multiscale Renyi distribution entropy for short-term heart rate variability analysis.

Background: Multiscale sample entropy (MSE) is a prevalent complexity metric to characterize a time series and has been extensively applied to the physiological signal analysis. However, for a short-term time series, the likelihood of identifying comparable subsequences decreases, leading to higher variability in the Sample Entropy (SampEn) calculation. Additionally, as the scale factor increases in the MSE calculation, the coarse-graining process further shortens the time series.

Risk of treatment-related toxicity from EGFR tyrosine kinase inhibitors: a systematic review and network meta-analysis of randomized clinical trials in -mutant non-small cell lung cancer.

Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective for non-small cell lung cancer (NSCLC) patients with -mutation, while their toxicity profiles are non-negligible and inconsistent. This study aimed to assess the toxicity intensity and profiles of different EGFR-TKIs in NSCLC patients with -mutation.

Methods: This random-effect Bayesian framed network meta-analysis (NMA) only included exclusively randomized clinical trials with demonstrated evidence on safety of EGFR-TKIs in NSCLC patients with EGFR-mutation.

Interfacing high numerical aperture metalenses with thermally expanded core fibers via 3D nanoprinting for advanced meta-fiber operation.

This study introduces a novel meta-fiber design that combines single-mode fibers with thermally expanded cores and nano-printed high numerical aperture metalenses. These advanced meta-fibers feature enlarged mode field diameters, offering improved mechanical stability, reduced environmental sensitivity and simplified metalens design by minimizing wavefront curvature. The concept's validity is confirmed through high numerical aperture metalenses, nanoprinted onto thermally expanded core fibers, demonstrating diffraction-limited focusing up to a numerical aperture of 0.

Ultra-Thin Highly Sensitive Electronic Skin for Temperature Monitoring.

Electronic skin capable of reliable monitoring of human skin temperature is crucial for the advancement of non-invasive clinical biomonitoring, disease diagnosis, and health surveillance. Ultra-thin temperature sensors, with excellent mechanical flexibility and robustness, can conformably adhere to uneven skin surfaces, making them ideal candidates. However, achieving high sensitivity often demands sacrificing flexibility, rendering the development of temperature sensors combining both qualities a challenging task.

IL-1 receptor-associated kinase 3 (IRAK3) in lung adenocarcinoma predicts prognosis and immunotherapy resistance: involvement of multiple inflammation-related pathways.

Background: Lung cancer is a globally prevailing malignancy, and the predominant histological subtype is lung adenocarcinoma (LUAD). IL-1 receptor-associated kinase 3 () has been identified in connection with innate immune and inflammatory response. The aim of this study is to investigate the impact of on prognosis and immunotherapy efficacy in LUAD, which remains incompletely elucidated.

The senolytic agent ABT263 ameliorates osteoporosis caused by active vitamin D insufficiency through selective clearance of senescent skeletal cells.

Background/objective: Active vitamin D insufficiency accelerates the development of osteoporosis, with senescent bone cells and the senescence-associated secretory phenotype (SASP) playing crucial roles. This study aimed to investigate whether the senolytic agent ABT263 could correct osteoporosis caused by active vitamin D insufficiency by selectively clearing senescent cells.

Methods: Bone marrow mesenchymal stem cells (BM-MSCs) from young and aged mice were treated with ABT263 in vitro, and 1,25(OH)D-insufficient (Cyp27b1) mice were administered ABT263 in vivo.

A Flexible Multifunctional Sensor Based on an AgNW@ZnONR Composite Material.

A multifunctional sensor comprising flexible and transparent ultraviolet (UV) photodetectors (PDs) with strain gauges based on Ag nanowire (AgNW)@ZnO nanorods (ZnONRs) was fabricated using a cost-effective, simple, and efficient method. High-aspect ratio silver nanowires were synthesized using the polyol method. An AgNW@ZnONR composite was formed via the hydrothermal method to ensure the multifunctional capability of the flexible sensors.

Interactions between Brassinosteroids and Strigolactones in Alleviating Salt Stress in Maize.

Exogenous brassinolide (BR) and strigolactones (SLs) play an important role in alleviating salt stress in maize. We studied the morphological and physiological responses of the salt-sensitive genotype PH4CV and salt-tolerant genotype Zheng58 to BR (1.65 nM), SL (1 µM), and BS (1.

CRISPR/Cas12a dual-mode biosensor for Staphylococcus aureus detection via enzyme-free isothermal amplification.

Accurate and reliable detection of Staphylococcus aureus (S. aureus) is essential for preventing infections, particularly in healthcare and food safety contexts. This work presents a novel dual-mode biosensor that integrates the CRISPR/Cas12a system with an enzyme-free isothermal amplification method for detecting S.

Functionally Modified Graphene Oxide as an Alternative Nanovehicle for Enhanced dsRNA Delivery in Improving RNAi-Based Insect Pest Control.

RNA interference (RNAi) has shown substantial promise as a sustainable pest management solution. However, the efficacy of RNAi-based insecticides heavily relies on advanced nanocarrier-mediated delivery systems. In this study, we modified raw graphene oxide into positively charged nanocarriers (GONs) tailored to bind with double-stranded RNA (dsRNA).

Electrochemical Dehydrogenative [3 + 2]/[5 + 2] Annulation of -Arylacrylamides with γ,σ-Unsaturated Malonates via Direct C(sp)-H/C(sp)-H Functionalization.

Herein, we introduce an electrochemical dehydrogenative [3 + 2]/[5 + 2] annulation of easily available -arylacrylamides with γ,σ-unsaturated malonates through C(sp)-H/C(sp)-H functionalization. The employment of inexpensive ferrocene as the redox catalyst allows access to diverse benzo[]azepin-2-ones in moderate to excellent yields without stoichiometric oxidants. This protocol features broad substrate scope and excellent selectivity, and mechanistic studies indicated that the reaction proceeded through the oxidation of a C(sp)-H bond to generate an alkyl radical, radical addition across the C═C bond, [3 + 2]/[5 + 2] annulations, and C(sp)-H functionalization cascades.

Time-dependent prognostic impact of circumferential resection margin in T3 thoracic esophageal squamous cell carcinoma.

Esophageal cancer presents a clinical challenge due to its high incidence and unfavorable prognosis. The prognostic role of the circumferential resection margin (CRM) remains highly controversial, potentially due to its temporal dynamics coupled with variability in follow-up durations across studies. We aimed to explore the time-dependent prognostic significance of CRM in T3 esophageal squamous cell carcinomas (ESCCs).