Publications by authors named "Xue Min Li"
is a widespread protozoan parasite associated with significant health risks in humans and animals. However, there is a lack of epidemiological data regarding this parasite in fur-animals. The present study aimed to investigate the prevalence and assemblage distribution of in fur-animals in northern China.
View Article and Find Full Text PDFTo examine the prevalence of E. bieneusi and Blastocystis sp. in foxes in China, this study analyzed the prevalence and distribution of genotypes or subtypes.
View Article and Find Full Text PDFAim: To isolate and identify the conjunctival microbiota of cataract patients and analyze the associated influencing factors.
Methods: This study recruited 216 participants (216 eyes) from April 2022 to July 2022. Under the condition of no antibiotic use prior to cataract surgery, sterile swabs were used to collect samples from the lower conjunctival sac.
Cyclospora spp., foodborne intestinal protozoa with potential zoonotic risk, are distributed across the globe. However, their presence in animals bred for fur has not been extensively studied, raising concerns about zoonotic transmission.
View Article and Find Full Text PDFArticle Synopsis
- Enterocytozoon bieneusi is a common zoonotic pathogen found in both humans and animals, posing significant public health risks, with limited data available on its prevalence in farmed minks and raccoon dogs in China.
- A study examined 510 animals, revealing an overall E. bieneusi prevalence of 18.6%, with 10.5% in minks and 28.1% in raccoon dogs, and identified ten different genotypes in these species.
- The detection of several genotypes previously associated with humans in minks and raccoon dogs suggests that these animals could be potential sources of human microsporidiosis, highlighting the need for enhanced monitoring and prevention strategies.
Article Synopsis
- Autoimmune nodopathy (AN) is a rare disease that can occur alongside membranous nephropathy (MN), and it involves the presence of specific antibodies in the serum.
- A study was done on a 65-year-old male with MN who exhibited symptoms like limb numbness and walking instability, revealing positive anti-CNTN1 antibodies, primarily of the IgG4 subtype, and significant nerve damage.
- The comparison of 35 cases of AN with MN to 51 cases of AN without MN found similar clinical characteristics, suggesting that while AN's symptoms may appear with MN, they do not worsen or improve with the presence of MN.
Aim: To investigate the therapeutic effects of hydrogel dressings on neurotrophic keratitis in rats.
Methods: Male Wistar rats, aged 42-56d, were randomly divided into control, experimental, and treatment groups, each consisting of five rats. The experimental and treatment groups underwent neurotrophic keratitis modeling in both eyes.
Objective: To explore clinical effect of different intervertebral fusion devices (cage) in treating postoperative recurrent lumbar disc herniation (LDH).
Methods: One hundred and forty-two LDH patients with recurrence after simple intervertebral disc nucleus pulpoideectomy from January 2019 to January 2021 were retrospectively analyzed. All patients were treated with combined underchannel fixation and interbody fusion and divided into a single anatomical group,two-anatomical group and a single banana group according to types and numbers of implanted cage.
Article Synopsis
- Citri Sarcodactylis Fructus is known for its cough-relieving and asthma-reducing properties, but its chemical makeup and how it functions in the body are not well understood.
- The study aimed to explore how these compounds distribute and metabolize in rats, identifying 40 prototype compounds and 78 metabolites through advanced chemical analysis.
- Results showed that the main compounds were found in the lungs while metabolites were present in plasma and kidneys, leading to the proposal of eight metabolic pathways for further research.
Article Synopsis
- An 8-year-old boy experienced panscleritis in his left eye and right epididymitis after a fall, highlighting the importance of identifying the cause.
- Systemic tests eliminated autoimmune diseases, tumors, and infections as causes for the scleritis, indicating it was likely due to local delayed-type hypersensitivity from the trauma.
- Both conditions were effectively treated with steroids for the scleritis and antibiotics for the epididymitis, emphasizing the need for prompt diagnosis and appropriate treatment to avoid vision loss.
Long-term effect of hospital volume on the postoperative prognosis of 158,618 patients with esophageal squamous cell carcinoma in China.
Front Oncol
February 2023
Background: The impact of hospital volume on the long-term survival of esophageal squamous cell carcinoma (ESCC) has not been well assessed in China, especially for stage I-III stage ESCC. We performed a large sample size study to assess the relationships between hospital volume and the effectiveness of ESCC treatment and the hospital volume value at the lowest risk of all-cause mortality after esophagectomy in China.
Aim: To investigate the prognostic value of hospital volume for assessing postoperative long-term survival of ESCC patients in China.
Background: This study was intended to construct a brand new prognostic nomogram after combine clinical and pathological characteristics to increases prognostic value in patients with esophageal squamous cell carcinoma.
Methods: A total of 1,634 patients were included. Subsequently, the tumor tissues of all patients were prepared into tissue microarrays.
Keratin pearls (KP) is an important indicator of the degree of tumor cell differentiation of esophageal squamous cell carcinomas (ESCC). However, the independent prognostic value of KP in ESCC patients remains unclear. The hematoxylin-eosin (H&E) stained tissue microarrays (TMAs) or whole slides of the patients were prepared to identify the existence of KP.
View Article and Find Full Text PDFAn updated patent review of IDO1 inhibitors for cancer (2018-2022).
Expert Opin Ther Pat
November 2022
Introduction: Indoleamine 2,3-dioxygenase 1 (IDO1) is highly related to the immune evasion of a wide range of malignancies due to its role in the immune suppression caused by the depletion of tryptophan (Trp) and the accumulation of kynurenine (Kyn). The combination of IDO1 inhibitors with other treatments represents a promising strategy in immunotherapy, although considerable challenges lie ahead.
Areas Covered: This review focuses on patent publications searched from Espacenet and Google Scholar, and related to IDO1 inhibitors with potential anti-cancer utilization during the period 2018-2022.
Purpose: Some studies indicated that gender is associated with prognostic of cancer, However, currently the prognostic value of gender for gastric cardia adenocarcinoma (GCA) survival is unclear. The aim of our study is to reveal the influence of gender on the prognosis of patients with GCA.
Patients And Methods: A total of 42,345 cases Chinese GCA patients were enrolled from our previously established GCA and esophageal cancer databases.
Age-related changes of lens thickness and density in different age phases.
Int J Ophthalmol
October 2022
Aim: To explore the changes in lens thickness and density with age.
Methods: A Chinese population-based retrospective study was performed. A total of 497 individuals (490 right eyes and 495 left eyes), ranging from 3 to 69 years old were included.
Diabetic retinopathy (DR) is one of the most common complications of diabetes and major cause of blindness among people over 50 years old. Current studies showed that the vascular endothelial growth factor (VEGF) played a central role in the pathogenesis of DR, and application of anti-VEGF has been widely acknowledged in treatment of DR targeting retinal neovascularization. However, anti-VEGF therapy has several limitations such as drug resistance.
View Article and Find Full Text PDFTransthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients.
World J Surg Oncol
June 2022
Background: This study compared the survival outcomes of different surgical approaches to determine the optimal approach for gastric cardia adenocarcinoma (GCA) and aimed to standardize the surgical treatment guidelines for GCA.
Methods: A total of 7103 patients with GCA were enrolled from our previously established gastric cardia and esophageal carcinoma databases. In our database, when the epicenter of the tumor was at or within 2 cm distally from the esophagogastric junction, the adenocarcinoma was considered to originate from the cardia and was considered a Siewert type 2 cancer.
Esophageal squamous cell carcinoma (ESCC) is one of the most common aggressive malignancies worldwide, particularly in northern China. The absence of specific early symptoms and biomarkers leads to late-stage diagnosis, while early diagnosis and risk stratification are crucial for improving overall prognosis. We performed UPLC-MS/MS on 450 ESCC patients and 588 controls consisting of a discovery group and two validation groups to identify biomarkers for early detection and prognosis.
View Article and Find Full Text PDFColorectal cancer (CRC) is the second leading cause of cancer death in the world. Immunotherapy using monoclonal antibodies, immune-checkpoint inhibitors, adoptive cell therapy, and cancer vaccines has raised great hopes for treating poor prognosis metastatic CRCs that are resistant to the conventional therapies. However, high inter-tumor and intra-tumor heterogeneity hinder the success of immunotherapy in CRC.
View Article and Find Full Text PDFRefractive Error and Eye Health: An Umbrella Review of Meta-Analyses.
Front Med (Lausanne)
November 2021
Article Synopsis
- The review examines the links between different refractive errors (myopia, hyperopia, astigmatism, anisometropia) and various eye health issues.
- Myopia is notably linked to higher risks for conditions like myopic macular degeneration, retinal detachment, and cataracts, but shows a lower risk for diabetic retinopathy and early age-related macular degeneration.
- Hyperopia increases the risk of early age-related macular degeneration, while both astigmatism and anisometropia are associated with a higher likelihood of strabismus (crossed eyes).
Applications of dynamic visual acuity test in clinical ophthalmology.
Int J Ophthalmol
November 2021
Article Synopsis
- Dynamic visual acuity tests (DVAT) are important for assessing vestibular function and visual ability in athletes, as well as diagnosing ocular diseases.
- DVAT offers advantages over traditional static visual tests by measuring dynamic and static signals separately.
- The review highlights the clinical significance of DVATs in evaluating various ocular disorders in ophthalmology.
Case Series: Ocular Trauma Secondary to Masks during the COVID-19 Pandemic.
Optom Vis Sci
November 2021
Significance: Previously, people had only recognized the discomfort of masks, and no one had ever realized the risk of ocular trauma associated with masks. We classify the causes of injuries into two categories and emphasize the importance of using masks properly.
Purpose: This study aimed to characterize and classify ocular injuries caused by masks.
Article Synopsis
- Doxorubicin, a common chemotherapy drug, is effective against tumors but has serious side effects, particularly heart damage (cardiotoxicity), leading to a need for protective strategies.
- Resveratrol, a natural compound, may help protect the heart from the harmful effects of doxorubicin, as suggested by a systematic review of 33 studies that explored its potential benefits.
- The review found that while doxorubicin causes significant heart-related issues, coadministration with resveratrol can reverse many of these harmful effects, highlighting its potential as a chemoprotective agent.
Leptin's concentration in tears and dry eye: a clinical observational study.
Int J Ophthalmol
January 2021
Article Synopsis
- The study explored the levels of leptin in tears and its relationship with dry eye symptoms and conditions.
- Tear samples were taken from both healthy individuals and dry eye patients, and various tests were conducted to assess the severity of dry eye disease (DED).
- Results showed a negative correlation between leptin levels and several DED indicators, suggesting leptin might play a role in the repair of ocular damage and improving dry eye symptoms.