LepR-Expressing Cells in Bone and Periodontium.

Objective: LepR-expressing cells (LepR cells), a critical subpopulation of mesenchymal stem cells, have gained increasing attention in the last decade. LepR cells have been found to play a crucial role in maintaining bone and periodontal homeostasis. This review summarizes current research advances focusing on the role of LepR cells and their underlying regulatory molecular mechanisms in bones and periodontium, aiming to provide a better understanding of the therapeutic potential of this cell lineage.

Tetrapyrrole organics-modified cerium nanozyme with enhanced oxidase-like activity for integration of detection and degradation of antibiotic.

The massive accumulation of antibiotics accelerates the emergence of antibiotic resistance causing inevitable risks to human and ecosystem. To realize the integration of detection and degradation of antibiotics, it is urgent for exploring novel nanozyme materials with the excellent catalytic activity. Integrating nanozyme with tetrapyrrole-based organics is an effective strategy to enhance the catalytic activity.

Comparative efficacy and safety of three endoscopic techniques for the treatment of large common bile duct stones (≥ 15 mm): Long-term follow-up.

Background & Aims: The effectiveness of endoscopic papillary large balloon dilation (EPLBD) alone versus EPLBD combined with endoscopic sphincterotomy (EST) in treating large common bile duct stones (CBDS, ≥ 15 mm) remains unclear. This study aimed to evaluate the safety and treatment outcomes of EPLBD combined with limited or large EST versus EPLBD alone in removing large CBDS.

Methods: Between January 2013 and September 2024, 408 patients underwent EPLBD, either alone or in combination with EST, to treat large CBDS (≥ 15 mm).

Uniformly dispersing SbSe nanoparticles in porous carbon as an anode material for enhancing sodium storage capacity.

About 60 nm SbSe nanoparticles are uniformly embedded in a porous carbon substrate to prepare a SbSe/C composite through a combination of pyrolysis reduction and solid-phase selenization. The SbSe/C anode exhibits excellent sodium storage capacity. The initial discharge capacity is up to 420 mA h g at 0.

A novel behavioral paradigm reveals the nature of confidence computation in multi-alternative perceptual decision making.

A central goal of research in perceptual decision making is to determine the internal computations underlying choice and confidence in complex, multi-alternative tasks. However, revealing these computations requires knowledge of the internal representation upon which the computations operate. Unfortunately, it is unknown how traditional stimuli (e.

Trifluoroacetic Acid as a Molecular Probe for the Dense Phase in Liquid-Liquid Phase-Separating Peptide Systems.

Although trifluoroacetic acid (TFA) is not typically considered a Hofmeister reagent, it has been demonstrated to modulate biocoacervation. We show that TFA can be employed to probe specific interactions in coacervating bioinspired peptide phenylalanine (Phe) F-labeled at a single site, altering its liquid-liquid phase separation (LLPS) behavior. Solid-state nuclear magnetic resonance (NMR) spectroscopy revealed two dynamically distinct binding modes of TFA with Phe, resulting in a structured, dipolar-ordered complex and a more dynamic complex, highlighting the proximity between TFA and Phe.

Endoscopic Papillary Large Balloon Dilatation With or Without Endoscopic Sphincterotomy in the Treatment of Common Bile Duct Stones.

Purpose Of Review: Endoscopic papillary large balloon dilation (EPLBD) has been proved to have better efficacy and safety in removing common bile duct stones. Conventional endoscopic sphincterotomy (EST) is usually performed before EPLBD. However, EPLBD without EST has recently reported short-term outcomes similar to those of EPLBD with EST.

A comprehensive time-series dataset linked to cyanobacterial blooms in Lake Taihu.

Lake Taihu has a history of recurrent harmful cyanobacterial blooms. There is a need to better understand the aquatic ecosystem of Lake Taihu in order to improve methods for controlling the cyanobacterial blooms. Based on the field measurement and satellite remote sensing, we produced and collected a time-series dataset, including the water quality, bio-optics, climate, and anthropogenic data of Lake Taihu (THQBCA), which could provide comprehensive information regarding cyanobacterial blooms.

Synergistic Effect of Anchoring Transitional/Interstitial Sites on Boosting Structural and Electrochemical Stability of O3-Type Layered Sodium Oxides.

O3-type layered oxides are considered promising cathode materials for next-generation high-energy-density sodium-ion batteries (SIBs). However, they face challenges, such as low rate capacity and poor cycling stability, which arise from structural deformation, sluggish Na diffusion kinetics, and interfacial side reactions. Herein, a synergistic substitution strategy for transitional and interstitial sites was adopted to improve the structure stability and Na diffusion kinetics of the O3-type NaNiFeMnO.

Self-improving generative foundation model for synthetic medical image generation and clinical applications.

In many clinical and research settings, the scarcity of high-quality medical imaging datasets has hampered the potential of artificial intelligence (AI) clinical applications. This issue is particularly pronounced in less common conditions, underrepresented populations and emerging imaging modalities, where the availability of diverse and comprehensive datasets is often inadequate. To address this challenge, we introduce a unified medical image-text generative model called MINIM that is capable of synthesizing medical images of various organs across various imaging modalities based on textual instructions.

No gender difference in confidence or metacognitive ability in perceptual decision-making.

Prior research has found inconsistent results regarding gender differences in confidence and metacognitive ability. Different studies have shown that men are either more or less confident and have either higher or lower metacognitive abilities than women. However, this research has generally not used well-controlled tasks or used performance-independent measures of metacognitive ability.

A Family of Two-Dimensional Quaternary Compounds ABXY (A = K, Na; B = Li, Na; X = Al, Ga, In; Y = P, As, Sb) for Optoelectronics Applications.

Expanding material types and developing two-dimensional (2D) semiconductor materials with high performance have been hotspots in the field. In this research, it is found that the 12 existing semiconductors ABXY (A = K, Na; B = Li, Na; X = Al, Ga, In; Y = P, As, Sb) have a pronounced layered structure. We predict their 2D structures and properties, using first-principles calculations.

Reassessing the Risk of Venous Thromboembolism (VTE) Events in Women.

This research aims to reassess women's risk of venous thromboembolism (VTE) events. We conducted an in-depth analysis of the environmental risk factors associated with VTE and their interactions with gender while also exploring the genetic underpinnings of the disease. VTE is identified as a multifactorial condition influenced by a combination of genetic, non-predisposing, and predisposing environmental factors.

Senolytic cocktail dasatinib and quercetin attenuates chronic high altitude hypoxia associated bone loss in mice.

Chronic high-altitude hypoxia (CHH) induces irreversible abnormalities in various organisms. Emerging evidence indicates that CHH markedly suppresses bone mass and bone strength. Targeting senescent cells and the consequent senescence-associated secretory phenotype (SASP) with senolytics is a recently developed novel therapy for multiple age-related diseases.

Nonheme iron catalyst mimics heme-dependent haloperoxidase for efficient bromination and oxidation.

The [Fe]/HO oxidation system has found wide applications in chemistry and biology. Halogenation with this [Fe]/HO oxidation protocol and halide (X) in the biological system is well established with the identification of heme-iron-dependent haloperoxidases. However, mimicking such halogenation process is rarely explored for practical use in organic synthesis.

Boosting the Durability of High-Pt-Content Fuel Cell Cathode Catalysts Through TaO Decorating.

Enhancing the durability of carbon-supported platinum catalysts (Pt/C) for the oxygen reduction reaction remains a significant challenge in the field of proton exchange membrane fuel cells (PEMFCs), especially for catalysts with high-Pt contents. Herein, a TaO decorating strategy that is capable of effectively boosting the durability of Pt/C catalysts even with a high-Pt content of 50 wt.% is introduced.

Development and validation of a radiopathomics model for predicting liver metastases of colorectal cancer.

Objective: To compare the ability of a model based on CT radiomics features, a model based on clinical data, and a fusion model based on a combination of both radiomics and clinical data to predict the risk of liver metastasis after surgery for colorectal cancer.

Methods: Two hundred and twelve patients with pathologically confirmed colorectal cancer were divided into a training set (n = 148) and a validation set (n = 64). Radiomics features from the most recent CT scans and clinical data obtained before surgery were extracted.

One-step hydrothermal synthesis of CQDs/TiO/NH-MIL-125 for efficient photocatalytic production of HO under visible light.

NH-MIL-125 and its derivatives are receiving more attention in various aspects of photocatalytic reactions, especially in the photocatalytic hydrogen peroxide (HO) production from water (HO) and oxygen (O), which is a promising and sustainable strategy. However, the generation of HO from NH-MIL-125 is far from satisfactory due to rapid photo-generated carriers recombination and poor surface electron transfer. In the work, the composite photocatalyst CQDs/TiO/NH-MIL-125 (C/T/NM) was designed for the first time by one-step hydrothermal method.

A Meta-analysis of the Regulation of Low-Density Lipoprotein Cholesterol and Proprotein Convertase Subtilisin-Kexin Type 9 with Inclisiran.

Objective: This study aimed to systematically evaluate the regulation of low-density lipoprotein cholesterol (LDL-C) and proprotein convertase subtilisin-kexin type 9 (PCSK9) with inclisiran using a meta-analysis.

Methods: A comprehensive search of PubMed, Embase, the Cochrane Library, and Web of Science was conducted for randomized controlled trials of inclisiran published up to April 2024. Stata software was used for statistical analysis of outcome indicators from the included studies.

Therapeutic potential of green tea catechins on the development of Parkinson's disease symptoms in a transgenic A53T mouse model.

This study aimed to evaluate the effects of green tea catechins on the prevention of Parkinson's disease neurobehavioral symptoms and α-synuclein blood plasma concentration in a hemizygous transgenic A53T mouse model. Thirty 6-month-old male mice were randomly assigned to three groups ( = 10/group): control, low-dose, and high-dose, receiving green tea polyphenol (GTP) treatment in their drinking water at 0%, 0.5%, and 1.

[Anatomical investigation of the venous system in pedicled nasal septal mucosal flap and its application in nasal skull base reconstruction].

To investigate the distribution and primary drainage sites of the venous drainage system in the pedicled nasal septal mucosal flap, as well as to examine protective measures for the venous system of the nasal septal mucosal flap and its application in repairing the nasal skull base through the anatomical study of the nasal septum mucosal venous system in cadavers. Gross anatomy dissections were performed on 13 sides perfused fresh frozen cadaveric head specimens. The nasal septum mucosal flap was separated along the perichondrium and subperiosteum, then passed across the vomer, anterior wall of sphenoid sinus, clivus, and towards the anterior edge of vertical plate of palatine bone.