Efficacy and safety of immunotherapy plus chemotherapy in advanced or metastatic pulmonary large-cell neuroendocrine carcinoma.

Background: Patients with advanced pulmonary large-cell neuroendocrine carcinoma (LCNEC) have a progressive clinical course and poor prognosis, and effective treatment options remain limited. This study assessed the efficacy and safety of immunotherapy plus chemotherapy for advanced LCNEC.

Methods: We retrospectively collected medical records of patients with advanced LCNEC who attended Shandong Cancer Hospital from January 2018 to December 2022.

Classification of additives and their influence mechanisms in improving the performance of biologically induced carbonate precipitation.

Microbial/enzyme induced carbonate precipitation (MICP/EICP) is one of the hot topics in the field of civil engineering, environmental engineering in recent years, primarily attributed to its environmental friendliness and low energy consumption. However, how to enhance its economic and technical feasibility to ensure its stable and high-performance is still a significant challenge. This paper systematically explores the strategic incorporation of additives as a promising approach to enhance the efficiency and controllability of MICP/EICP process.

Renal-clearable and tumor-retained nanodots overcoming metabolic reprogramming to boost mitochondrial-targeted photodynamic therapy in triple-negative breast cancer.

Background: Targeting tumor metabolism reprogramming has demonstrated a synergistic antitumor effect in photodynamic therapy of triple-negative breast cancer (TNBC). However, such a combination therapeutic regimen has encountered challenges, such as limited photosensitizer bioavailability and severe drug toxicity.

Methods And Results: Herein, ultrasmall metal-organic frameworks (MOFs) nanodots (MSPC) that encapsulate metabolism inhibitors and mitochondria-targeted photosensitizers are designed and fabricated for synergistic photodynamic therapy (PDT) of TNBC.

Targeting the CXCR7 pathway with TC14012 to inhibit endothelial necroptosis and lung cancer metastasis.

Endothelial necroptosis plays a crucial role in regulating cancer metastasis. Our previous research demonstrated that TC14012, which is an agonist of CXCR7, exhibits protective effects against endothelial injury. This study was designed to elucidate the effects of TC14012 on endothelial necroptosis and cancer lung metastasis, along with deciphering the underlying molecular mechanisms.

Evaluating modified atmosphere with variable CO₂-O₂ concentrations for management and quality preservation in Rice storage.

This study explored the efficacy of CO₂-MA with variable CO₂-O₂ concentrations (TA: 2 % O₂ + 35 % CO₂, TB: 14 % O₂ + 35 % CO₂, TC: 21 % O₂ + 35 % CO₂, TD: 21 % O₂ + 60 % CO₂) in controlling and preserving rice quality. TD exhibited the highest efficacy, achieving rapid and complete pest mortality within 48 h, particularly in the resilient pupal stage, and nearly 100 % mortality under grain-embedded conditions within 10 days. Quality assessments revealed that TD effectively mitigated lipid oxidation by reducing aldehydes and alcohols, major contributors to rice aging and off-flavors while maintaining acceptable enzymatic activities and VOC profiles.

A Robust Method for Real Time Intraoperative 2D and Preoperative 3D X-Ray Image Registration Based on an Enhanced Swin Transformer Framework.

In image-guided surgery (IGS) practice, combining intraoperative 2D X-ray images with preoperative 3D X-ray images from computed tomography (CT) enables the rapid and accurate localization of lesions, which allows for a more minimally invasive and efficient surgery, and also reduces the risk of secondary injuries to nerves and vessels. Conventional optimization-based methods for 2D X-ray and 3D CT matching are limited in speed and precision due to non-convex optimization spaces and a constrained searching range. Recently, deep learning (DL) approaches have demonstrated remarkable proficiency in solving complex nonlinear 2D-3D registration.

Designing Positionally Stable Smooth Breast Implants.

: The voluntary recall and ban of several textured breast implant models worldwide, secondary to their association with Breast Implant-Associated Anaplastic Large Cell Lymphoma, has limited the key benefit of a textured surface─positional stability. We have engineered a Positionally Stable Smooth Implant (PSSI) containing millimeter-scaled cylindrical wells on the implant surface for capsule ingrowth and device stabilization. : To evaluate the long-term positional stability of PSSI designs and characterize capsule formation.

STX17-DT facilitates axitinib resistance in renal cell carcinoma by inhibiting mitochondrial ROS accumulation and ferroptosis.

Axitinib resistance remains a serious challenge in the treatment of advanced renal cell carcinoma (RCC), and the underlying mechanisms are not fully understood. Here, we constructed an in vivo axitinib-resistant RCC model and identified the long non-coding RNA STX17-DT as a driver of therapy resistance in RCC. The expression of STX17-DT was significantly elevated in axitinib-resistant RCC cells and correlated with poorer prognosis in RCC patients.

Silver-mediated formal [4π + 2] cycloaddition reactions of bicyclobutanes with nitrile imines: access to 2,3-diazobicyclo[3.1.1]heptenes.

Despite recent advances in the synthesis of aza-bicyclo[3.1.1]heptanes (aza-BCHeps, which have an sp-hybridized nitrogen atom) and azabicyclo[3.

Ornithinibacillus xuwenensis sp. nov., A Novel Thermotolerant Bacterium Isolated from Mangrove Sediment.

A Gram-stain positive, long-rod-shaped, motile, and aerobic bacterial strain, designated 16A2E, was isolated from mangrove sediment sample. The 16S rRNA gene sequence similarity analysis indicated that strain 16A2E exhibited high similarity to Ornithinibacillus contaminans CCUG 53201 (98.2%), Ornithinibacillus bavariensis WSBC 24001 (98.

Synthesis, Characterization, and Catalytic Activity of Ni(0) (DQ)dtbbpy, an Air-Stable, Bifunctional Red-Light-Sensitive Precatalyst.

Despite a well-established and growing body of work on nickel(0) precatalysts, the potential of nickel(0) complexes as bifunctional precatalysts remains underexplored. In this study, we synthesized, characterized, and evaluated the catalytic activity of (Ni(0)(DQ)dtbbpy), a bifunctional, red-light-sensitive, and air-stable nickel(0) complex. Owing to its unique photophysical properties, it effectively catalyzed the etherification and amination of aryl bromides under 620-630 nm light irradiation, functioning as both a photocatalyst and an active metal catalyst.

Multivalent Redox Reversible Conversion-Enhanced Electrochemiluminescence Strategy for Progesterone Detection.

The performance of electrochemiluminescence (ECL) sensing platforms, especially the sensitivity, relies on an efficient signal enhancement mechanism and presents a critical challenge in developing novel strategies simultaneously. In this work, we reported a multivalent redox reversible conversion-enhanced ECL strategy based on the redox reactions of two pairs of multivalent metal elements on the electrode surface. TiO-loaded Eu(OH) (Eu(OH)@TiO) was introduced as a dual-enhanced coreactant accelerator to catalyze the oxidation process of tripropylamine (TPrA), thus improving the reaction rate at the sensing interface and the ECL strength of the luminophore.

CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway.

CCR2, a member of the G protein-coupled receptor (GPCR) superfamily, is widely expressed on monocytes, macrophages, activated T cells, and other cell types, and plays a critical role in coordinating the immune response to various infections. Here we demonstrate that CCR2 expression is significantly elevated during Chlamydia muridarum (C. muridarum) respiratory infection, and its absence leads to exacerbated susceptibility, as evidenced by significant weight loss, higher bacterial loads, severe lung pathology, and elevated levels of inflammatory cytokines (il-1β, tnfα, and il-6).

MAPbX Perovskite Single Crystals for Advanced Optoelectronic Applications: Progress, Challenges, and Perspective.

Perovskite single crystals have garnered significant attention due to their impressive properties in optoelectronic applications, including long carrier diffusion lengths, low trap-state densities, and enhanced stability. Methylamino lead halide perovskite (MAPbX, where X is a halogen such as Cl, Br, or I) is a notable example of a metal halide perovskite with desirable properties and ideal cubic perovskites with a tolerance factor between 0.9 and 1.

Advancements in Diagnosis and Treatment of Cardiac Sarcomas: A Comprehensive Review.

Cardiac sarcomas are rare, aggressive malignancies originating from various cardiac cell types, presenting significant challenges in both diagnosis and treatment. This comprehensive review explores recent advancements in diagnosis and treatment of cardiac angiosarcoma, fibrosarcoma, leiomyosarcoma, and rhabdomyosarcoma. And we briefly discuss the exceedingly rare occurrence of cardiac osteosarcoma and present our perspectives on its treatment.

Lipidomic profiling reveals the protective mechanism of nitrogen-controlled atmosphere on brown rice quality during storage.

Rice, a globally important staple, requires effective preservation methods to maintain its quality during extended storage. This study explored the efficacy of nitrogen-controlled atmosphere (NCA) storage in preserving the quality of brown rice during a one-year period using UHPLC-MS/MS based lipidomic profiling. A total of 1013 lipids were identified and categorized into five main groups.

Compact single-shot multispectral polarization imager through joint spectral-polarization encoding.

The technique of spectral polarization imaging (SPI) is a potent detection tool in various fields due to its ability to capture multi-dimensional information. However, existing SPI systems usually face challenges associated with architectural complexity and computational requirements, rendering them unsuitable for handheld, on-board, and real-time applications. Consequently, a compact single-shot multispectral polarization imager (CSMPI) is proposed, which employs a combined spectral-polarization encoding strategy to address the aforementioned issues.

Dandelion extract suppresses the stem-like properties of triple-negative breast cancer cells by regulating CUEDC2/β-catenin/OCT4 signaling axis.

Ethnopharmacological Relevance: Triple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer, featuring a high proportion of cancer stem cells (CSCs) and the poorest clinical outcomes. Taraxacum mongolicum Hand. -Mazz.

Design, synthesis, and evaluation of carboxylic acid-substituted celecoxib isosteres as potential anti-inflammatory agents.

A library comprising twenty-four isosteric derivatives of celecoxib substituted with carboxylic acid (labeled as 5a-5x), was synthesized and characterized through H NMR, C NMR, HRMS, and elemental analysis. Molecular docking studies revealed that all compounds successfully docked into the binding pocket of COX-2, and the introduction of carboxyl group enhances the interaction between the derivatives and COX-2. The compounds were further evaluated for cell toxicity, and in vitro anti-inflammatory activity.

Continuous Core Body Temperature Monitoring for Heatstroke Alert via a Wearable In-Ear Thermometer.

Heatstroke, a global concern exacerbated by climate change, poses significant health risks, potentially leading to multiorgan damage and fatalities. Core body temperature (CBT) is a critical and precise indicator of heatstroke, and its continuous monitoring could serve as a pivotal tool for early detection. Traditional CBT measurements, often invasive (e.

Creep model of bond-degradation in deep granite based on variable radius particle clump.

The creep failure of rocks is related to its microstructure, external loading and time. A nonlinear yield model was introduced to describe the variation in the cohesion and friction angle with plastic strain and intergranular stress. The mechanical properties and creep characteristics of deep granite were obtained by indoor tests, and a variable radius particle clump model was constructed based on the particle flow method.

Visible-Light-Triggered Mn(CO)-Catalyzed Carbonylation of (Hetero)aryl Chlorides.

Carbonylation of aryl electrophiles is an important method for constructing aromatic carbonyl compounds for materials science and pharmaceutical applications. However, there have been few studies on the carbonylation of abundant, inexpensive aryl chlorides. Moreover, the existing carbonylation methods usually require a high temperature, control of the CO pressure, and structurally complex catalysts and ligands.

EHMT2-mediated R-loop formation promotes the malignant progression of prostate cancer via activating Aurora B.

Background: Chromosomal instability (CIN), a hallmark of cancer, is commonly linked to poor prognosis in high-grade prostate cancer (PCa). Paradoxically, excessively high levels of CIN may impair cancer cell viability. Consequently, understanding how tumours adapt to CIN is critical for identifying novel therapeutic targets.

Short-term visual adaptation to body shape induces sustained aftereffect on body size estimation.

Visual adaptation to thin or large bodies was found to shift the subjective body normality towards the adapting body shape. Here we investigated the persistency of such adaptation effect by tracking the timecourse of decay of short-term body size adaptation in young healthy Chinese women. Participants adapted to contracted or expanded body images of unfamiliar female volunteers with a top-up paradigm.