Oxygen/siRNA-carrying fluoro-nanosensitizers for radio-immunotherapy sensitization.

The anti-tumor efficacy of radiotherapy (RT) is limited by the hypoxic and immunosuppressive tumor microenvironment (TME), which leads to RT resistance and failure in eradicating distant metastatic lesions. Herein, we developed a fluorinated nanosensitizer that could deliver both oxygen (O) and ADAR1 siRNA into tumor cells to reinforce RT by alleviating hypoxia and immunosuppression. Fluorinated poly(β-amino ester) (fPBAE) was designed to complex ADAR1 siRNA (siADAR1) via electrostatic attraction and load O due to the O-dissolving capacity of fluoroalkyls.

Pickering self-floating adsorbents: Natural tea polyphenol nanoparticle-based beads for efficient separation of cationic dyes with simple recovery.

Energy-efficient separation and recovery of adsorbents, particularly nano/micro-adsorbent materials, and effective adsorption of water-soluble ionic dyes continue to be crucial challenges in wastewater treatment. In this study, a novel water-suspended Pickering adsorbent with adsorption selectivity was developed using natural polyphenol nanomaterials. The preparation procedure is simple and cost-effective, involving ultrasonic emulsification and calcium alginate crosslinking without the use of complex equipment or expensive chemicals.

Comparison of ATG-thymoglobulin with atg-fresenius in patients with hematological malignancies who undergo allogeneic hematopoietic stem cell transplantation: a propensity score-matched analysis.

We retrospectively compared the outcomes of 166 patients with hematological malignancies who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) using ATG-Thymoglobulin (ATG-T) at 10 mg/kg or ATG-Fresenius (ATG-F) at 20 mg/kg. Propensity score matching (PSM) analysis was applied, with 44 patients assigned to each group. The ATG-T group showed a trend toward a higher incidence of bacterial infections (72.

Stress hyperglycemia ratio as an independent predictor of acute kidney injury in critically ill patients with acute myocardial infarction: a retrospective U.S. cohort study.

Background: Acute kidney injury (AKI) is a frequent and severe complication in critically ill patients with acute myocardial infarction (AMI), significantly worsening prognosis. Identifying early risk markers for AKI in AMI patients is critical for timely intervention. The stress hyperglycemia ratio (SHR), a marker of acute glycemic response to physiological stress, has been proposed as a predictor of AKI, but its role remains unclear.

Responsive hydrogel modulator with self-regulated polyphenol release for accelerating diabetic wound healing precise immunoregulation.

Nonhealing chronic wounds are intractable clinical complications of diabetes and are characterized by high protease activity, severe oxidative stress and sustained inflammatory response. In this case, the development of functional hydrogel dressings to modulate the immune microenvironment is a well-known strategy, where the precise stimuli-responsive and spatiotemporally controlled release of bioactive molecules remains a huge challenge. Herein, we developed responsive hydrogels with self-regulated bioactive molecule release based on the protease activity in diabetic wound sites, to serve as a smart immune microenvironment modulator for accelerating wound healing.

An open-label, randomized, post-authorization study of mirabegron in Chinese participants with overactive bladder.

Objective: To assess efficacy and safety of mirabegron 25 mg/day and 50 mg/day for overactive bladder in Chinese participants.

Methods: Participants of ≥18 years with overactive bladder symptoms lasting for ≥12 weeks, a mean of ≥8 micturitions per 24 h, and a mean of at least one episode of Grade 3 or 4 urgency or urge incontinence per 24 h based on the Patient Perception of Intensity of Urgency Scale over a 3-day micturition diary period were randomized 2:1 to open-label treatment with oral mirabegron 50 mg or 25 mg once daily for 12 weeks (15 sites in China, January 2021-March 2022). A dose escalation from 25 mg/day to 50 mg/day was permitted at weeks 4 and 8 according to the investigators' discretion.

Research on Precision Medicine AI Algorithm for Neuro Immune Gastrointestinal Diseases based on Quantum Biochemistry and Computational Cancer Genetics.

Objective: The objective of this study is to conduct network toxicology analysis based on smoking habits and develop a simpler and more effective toxicology product ingestion control system.

Background: Smoking behavior can affect the pathogenesis and prognosis of neuroimmune gastrointestinal diseases.

Aims: The purpose of developing tools to assist clinical practice is to avoid the harm of cigarettes to the human body.

Chitosan-based biomaterials for bone tissue engineering.

Common critical size bone defects encountered in clinical practice often result in inadequate bone regeneration,primarily due to the extent of damage surpassing the inherent capacity of the body for self-healing. Bone tissue engineering scaffolds possess the desirable characteristics of biomimetic bone structure, simulated extracellular matrix, optimal mechanical strength, and biological functionality, rendering them the preferred option for the treatment of bone defects. Chitosan demonstrates favorable biocompatibility, plasticity, and a range of biological activities, rendering it a highly appealing material.

SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer.

Over 60% of breast cancer cases are diagnosed with estrogen-receptor (ER) positive. Tamoxifen (TAM), a commonly employed medication for ER-positive breast cancer, often yields suboptimal therapeutic outcomes due to the emergence of TAM resistance, leading to the recurrence and a poor prognosis. The copper transporter, solute carrier family 31 member 1 (SLC31A1), has been associated with tumor aggressiveness and unfavorable outcomes in various types of tumors.

A Library of Polyphenol-Amino Acid Condensates for High-Throughput Continuous Flow Production of Nanomedicines with Ultra-High Drug Loading.

Synthesizing high drug-loading nanomedicines remains a formidable challenge, and achieving universally applicable, continuous, large-scale engineered production of such nanomedicines presents even greater difficulties. This study presents a scalable library of polyphenol-amino acid condensates. By selecting amino acids, the library enables precise customization of key properties, such as carrier capacity, bioactivity, and other critical attributes, offering a versatile range of options for various application scenarios.

Nest site selection during the second breeding attempt in Japanese tits (Parus minor): effects of nest site characteristics.

Numerous investigations focusing on nest site selection among multiple-brooded bird species have revealed a common trend: breeders frequently return to their first nest sites for another brood during the same breeding season. This behavior suggests a strong preference for familiar locations, which may offer advantages such as increased safety, resource availability, and the efficiency of parental care. However, there were also instances where breeders moved to a new nest site.

Efficacy and safety of non-invasive low-frequency tibial nerve stimulator in overactive bladder.

Objectives: To evaluate the efficacy and safety of a non-invasive low-frequency tibial nerve stimulator (TNS-01) vs sham control in relieving the symptoms of overactive bladder (OAB) patients.

Patients: Participants who were diagnosed with primary OAB or exhibited at least one OAB symptom. All participants underwent three 30-min intervention sessions weekly.

Development of Electrospinning Setup for Vascular Tissue-Engineering Application with Thick-Hierarchical Fiber Alignment.

Background: Tissue engineering holds promise for vascular repair and regeneration by mimicking the extracellular matrix of blood vessels. However, achieving a functional and thick vascular wall with aligned fiber architecture by electrospinning remains a significant challenge.

Methods: A novel electrospinning setup was developed that utilizes an auxiliary electrode and a spring.

Construction and characterization of chimeric FcγR T cells for universal T cell therapy.

Background: Several approaches are being explored for engineering off-the-shelf chimeric antigen receptor (CAR) T cells. In this study, we engineered chimeric Fcγ receptor (FcγR) T cells and tested their potential as a versatile platform for universal T cell therapy.

Methods: Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64.

Short- and Mid-Term Outcomes Following ALIF and TLIF in L5-S1 Isthmic Spondylolisthesis Patients.

Background: A limited number of studies have compared the outcomes of anterior lumbar interbody fusion (ALIF) to transforaminal lumbar interbody fusion (TLIF) for the treatment of isthmic spondylolisthesis. This study aims to compare postoperative complications between these two surgical approaches.

Methods: A retrospective review was performed using a large national database.

Epidemiological Characteristics and Diagnostic Outcomes of Suspected Occupational Noise-Induced Deafness - Guangdong Province, China, 2014-2023.

Introduction: Suspected occupational noise-induced deafness (ONID) represents the most prevalent suspected occupational disease in Guangdong Province and is among the most frequently reported nationwide. Given its public health significance, we conducted a systematic investigation of suspected ONID cases in Guangdong from 2014 to 2023, analyzing their epidemiological characteristics and diagnostic outcomes to inform evidence-based policies for ONID prevention and management.

Methods: Data on suspected ONID cases reported in Guangdong Province from 2014 to 2023 were extracted from the "Occupational Diseases and Health Hazard Factors Monitoring Information System.

Rolling schedule design for the ESP rolling process based on NSGA-II-DE.

Multiple processes connected closely during the endless strip production (ESP) rolling, it is difficult to obtain the global optimal solution by multi-objective modelling of a single process, and the parameters to be optimized coupled with each other. To obtain the optimal solution, a multi-objective optimization model combining the power consumption, product quality, and loading balance was proposed for the design of an ESP rolling schedule. The thickness and heating temperature were simultaneously taken as the decision variables for coupling the temperature and loading in the rolling process, and the non-dominated sorting genetic algorithm-II (NSGA-II) based on differential evolution (NSGA-II-DE) was applied to obtain the Pareto solutions.

Study on jet dynamic impact performance under the influence of standoff.

Due to the sensitivity of the shaped charge jet to standoff and the complexity of its impact under lateral disturbances, this study aims to investigate the dynamic impact evolution of the jet influenced by standoff and lateral disturbances. A finite element model for the dynamic impact of shaped charge jets was established. Dynamic impact experiments were designed and conducted to validate the effectiveness of the numerical simulations.

Research and development of new intelligent foaming and discharging agent system.

The application of classic foaming agent faces several issues, including excessive use of defoaming agent, inadequate defoaming, pipeline blockage due to silicone oil precipitation, and high development cost of the foaming agent. To address the aforementioned issues, a novel intelligent foaming agent was created. This resulted in the development of a new intelligent foaming and discharging agent system.

Experimental Study on the Size Effect of Compression-Shear Fracture Characteristics of Rock-like Materials Containing Open Cracks.

Understanding fracture mechanics in rock-like materials under compression-shear condition is critical for predicting failure mechanisms in various engineering applications, such as mining and civil infrastructure. This study conducted uniaxial compression tests on cubic gypsum specimens of varying sizes (side lengths of 75 mm, 100 mm, 125 mm, and 150 mm) and crack inclination angles (ranging from 0° to 90°) to assess the size effect on fracture behavior. The effects of specimen size and crack inclination on fracture characteristics, including strength, failure mode, and crack initiation angle, were analyzed based on the maximum tangential stress (MTS) criterion and the generalized maximum tangential stress (GMTS) criterion, with relative critical size (α) and relative openness ().

The comparative analysis between sporadic and genetic Creutzfeldt-Jakob disease in China.

Objectives: Creutzfeldt-Jakob disease (CJD) is a transmissible neurodegenerative disorder with a fatal outcome. The present study investigated the difference on demographic, clinical and laboratory data between the patients with sporadic CJD (sCJD) and genetic CJD (gCJD).

Methods: Thirty-eight patients with CJD were enrolled in this study, including 28 patients with sCJD and 10 patients with gCJD.

Manipulating Electron-Phonon Coupling for Efficient Tin Halide Perovskite Blue LEDs.

Low-dimensional perovskites have opened up a new frontier in light-emitting diodes (LED) due to their excellent properties. However, concerns regarding the potential toxicity of Pb limited their commercial development. Sn-based perovskites are regarded as a promising candidate to replace Pb-based counterparts, while they generally exhibit strong electron-phonon coupling and consequently blue emission quenching at room temperature (RT), thus the Sn-based perovskite blue LED devices have not yet been reported.

Two-point methods for evaluation of the minimum zone circle.

According to the cross-distribution of four control points of the minimum zone circle, the four-point conditions that two control points on the circumscribed circle and two control points on the inscribed circle meet are proposed. Based on these conditions, a two-point method is proposed, which is suitable not only for the determination of two control points on the circumscribed circle but also for the determination of two control points on the inscribed circle. In the iterative process, redundant data points can be simply determined by using dichotomy in order to improve computational efficiency.