Osteosarcoma, a malignant bone tumor, faces significant treatment challenges. Enhancer of zeste homolog 2 (EZH2) shows aberrant expression in various tumors including osteosarcoma, which is identified as a potential therapeutic target. The anti-cancer efficacy of EZH2 inhibitor GSK126 has attracted attention, yet its impact on osteosarcoma cells was not fully understood.
View Article and Find Full Text PDFPhosphoglycerate mutase 1 (PGAM1) has been identified as a key player in the progression and metastasis of various human cancer types, including breast cancer (BC); however, its precise oncogenic mechanism remains unclear. The present study aimed to investigate the oncogenic mechanisms of PGAM1 and establish its potential as a therapeutic target. Comprehensive analyses from the Tumor Immune Estimation Resource 2.
View Article and Find Full Text PDFWorldwide, ovarian cancer (OC) is the seventh common cancer and the second most common cause of cancer death in women. Due to high rates of relapse, there is an urgent need for the identification of new targets for OC treatment. The far-upstream element binding protein 1 (FBP1) and enhancer of zeste homolog 2 (EZH2) are emerging proto-oncogenes that regulate cell proliferation and metastasis.
View Article and Find Full Text PDFData are a strategic resource for industrial production, and an efficient data-mining process will increase productivity. However, there exist many missing values in data collected in real life due to various problems. Because the missing data may reduce productivity, missing value imputation is an important research topic in data mining.
View Article and Find Full Text PDFAmentoflavone is an active phenolic compound isolated from over 40 years. Amentoflavone has been extensively recorded as a molecule which displays multifunctional biological activities. Especially, amentoflavone involves in anti-cancer activity by mediating various signaling pathways such as extracellular signal-regulated kinase (ERK), nuclear factor kappa-B (NF-κB) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), and emerges anti-SARS-CoV-2 effect via binding towards the main protease (Mpro/3CLpro), spike protein receptor binding domain (RBD) and RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2.
View Article and Find Full Text PDFWith the new municipal solid waste classification policy implemented in China, attention on achieving the waste-to-energy disposal of "dry waste" has been growing. Pyrolysis conversion of organic waste into value-added chemicals is a promising method to treat solid waste. However, after removing the non-combustible components of "dry waste", the obtained high-organic solid waste (HSW) contains various heavy metals, which requires urgent attention during thermochemical conversion.
View Article and Find Full Text PDFChromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a multifunctional protein participated in diverse cellular processes, including chromosome remodeling, cell differentiation and development. CHD1L is a regulator of chromosomal integrity maintenance, DNA repair and transcriptional regulation through its bindings to DNA. By regulating kinds of complex networks, CHD1L has been identified as a potent anti-apoptotic and pro-proliferative factor.
View Article and Find Full Text PDFCo-combustion of coal and wheat straw (WS) was conducted in a lab-scale BFB combustor. Fuel composition (coal, 70%coal+30%WS), temperature (750, 800, 850, 900, 950 °C), secondary air ratio (0, 10%, 20%, 30%) were varied to on the release of gaseous pollutant was studied. CO, NO and SO concentration in flue gas (FG) were measured on-line by a flue gas analyzer.
View Article and Find Full Text PDFLight Detection and Ranging (LiDAR) produces 3D point clouds that describe ground objects, and has been used to make object interpretation in many cases. However, traditional LiDAR only records discrete echo signals and provides limited feature parameters of point clouds, while full-waveform LiDAR (FWL) records the backscattered echo in the form of a waveform, which provides more echo information. With the development of machine learning, support vector machine (SVM) is one of the commonly used classifiers to deal with high dimensional data via small amount of samples.
View Article and Find Full Text PDFAn intercalation-exfoliation method is applied to modify the natural kaolin mineral, so that to improve the enrichment effects on heavy metals (Zn, Pb, Cr & Cd) during coal combustion. The modified kaolin is scanned by electron microscope (SEM), X-ray diffraction (XRD), Fourier Transform infrared spectroscopy (FTIR) and Brunner-Emmett-Teller (BET), which indicate that the natural kaolin is peeled off to form fine flakes and the interlayer spacing is significantly increased. The coal-kaolin combustion tests were performed in a tube furnace from 900°C to 1300°C.
View Article and Find Full Text PDFComput Intell Neurosci
February 2017
Texture image classification is an important topic in many applications in machine vision and image analysis. Texture feature extracted from the original texture image by using "Tuned" mask is one of the simplest and most effective methods. However, hill climbing based training methods could not acquire the satisfying mask at a time; on the other hand, some commonly used evolutionary algorithms like genetic algorithm (GA) and particle swarm optimization (PSO) easily fall into the local optimum.
View Article and Find Full Text PDFFisheye lens can provide a wide view over 180°. It then has prominence advantages in three dimensional reconstruction and machine vision applications. However, the serious deformation in the image limits fisheye lens's usage.
View Article and Find Full Text PDF