Improving reliability of movement assessment in Parkinson's disease using computer vision-based automated severity estimation.

Background: Clinical assessments of motor symptoms rely on observations and subjective judgments against standardized scales, leading to variability due to confounders. Improving inter-rater agreement is essential for effective disease management.

Objective: We developed an objective rating system for Parkinson's disease (PD) that integrates computer vision (CV) and machine learning to correct potential discrepancies among raters while providing the basis for model performance to gain professional acceptance.

Quercetin prevents the loss of chondrogenic capacity in expansion cultured human auricular chondrocytes by alleviating mitochondrial dysfunction.

Objective: To explore the characteristics of cellular senescence in human auricular chondrocytes during long-term in vitro culture and to evaluate the effects of anti-senescence treatments on enhancing their chondrogenic function.

Methods: Auricular chondrocytes exhibited senescence-related characteristics after prolonged expansion in culture. To identify senescence inducers, transcriptome sequencing was performed, with findings corroborated by transmission electron microscopy analyses.

Impacts of climate change on the suitable habitat of Angelica sinensis and analysis of its drivers in China.

Climate change is shifting optimal habitats for medicinal plants, potentially compromising the efficacy and therapeutic value of herbal remedies. Global warming and increased extreme weather events threaten the sustainability and pharmaceutical integrity of Angelica sinensis (Oliv.) Diels (A.

Quantitatively tracing the decomposition of endogenous particulate organic carbon during sinking in (sub-)deep reservoirs: Using radiocarbon isotopes ΔC.

The rapid expansion of reservoirs, coupled with increasing eutrophication, has profoundly influenced regional and global carbon cycles. To precisely assess the carbon sink potential of reservoirs, it is crucial to quantify the decomposition of endogenous particulate organic carbon (POC) during the deposition and sinking of particulate matter in reservoirs. This is particularly important in the context of rising temperatures and intensified human activities.

Hydrothermal synthesis of bismuth cluster-modified covalent triazine framework composite photocatalysts with effective performance in selective CC bond cleavage of lignin.

With regard to the low production of aromatic monomers generated from renewable resources, improving the selective CC bond cleavage in lignin could be the solution. Here, a novel CTF-Bi cluster photocatalyst was firstly prepared by hydrothermal method. A series of Bi/CTF composite photocatalysts varying in Bi cluster content were synthesized using confined growth techniques.

Droplet-based bioprinting for the tailored fabrication of bacteria-laden living materials.

Droplet-based bioprinting (DBB) allows for high precision, noncontact, and on-demand distribution of bioinks, hence it has been widely utilized in the preparation of bacteria-laden living materials (BLMs). Nonetheless, discontinuous ink deposition makes it challenging to fabricate large-sized intact living structures via this technique. Herein, we explore the way of using DBB to construct centimeter-scale BLMs with bespoke geometries, and further demonstrate its potential applicability in sensing-responsive device by integrating engineered bacteria.

Biomechanical analysis of nickel-titanium (NiTi)-cobalt-chromium (CoCr) hybrid-braided dense-mesh stents for carotid artery stenosis.

This study investigates NiTi-CoCr hybrid carotid artery stents to enhance mechanical properties over NiTi-only designs. Different configurations (24NiTi, 20NiTi-4CoCr, 16NiTi-8CoCr, and 12NiTi-12CoCr) were evaluated through radial compression and bending simulations. The 12NiTi-12CoCr stent showed the highest radial support (39.

N-CADHERIN/CD168 subpopulation determines therapeutic variations of UC-MSCs for cardiac repair after myocardial infarction.

Background: The efficiency of mesenchymal stem cells (MSCs) in treating myocardial infarction (MI) remains inconsistent, which limits their therapeutic applications. Therefore, exploring the mechanism for the inconsistent efficacy of MSCs and identification the criteria for screening MSCs are important for improving the efficiency of MSCs.

Methods: Mouse model after MI was utilized to test the role of MSCs from different donors and the functional subpopulation in improving cardiac function.

LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma.

In a retrospective analysis of clinical data from 587 DLBCL (diffuse large B-cell lymphoma) patients in China, 13.8% of cases were associated with HBV (hepatitis B virus) infection, leading to distinct clinical features and poorer prognosis. Moreover, HBV infection has a more pronounced impact on the survival of the GCB (germinal center B-cell-like) type DLBCL patients compared to the ABC (activated B-cell-like) type.

MetalPrognosis: A Biological Language Model-Based Approach for Disease-Associated Mutations in Metal-Binding Site Prediction.

Protein-metal ion interactions play a central role in the onset of numerous diseases. When amino acid changes lead to missense mutations in metal-binding sites, the disrupted interaction with metal ions can compromise protein function, potentially causing severe human ailments. Identifying these disease-associated mutation sites within metal-binding regions is paramount for understanding protein function and fostering innovative drug development.

Advancing mRNA subcellular localization prediction with graph neural network and RNA structure.

Motivation: The asymmetrical distribution of expressed mRNAs tightly controls the precise synthesis of proteins within human cells. This non-uniform distribution, a cornerstone of developmental biology, plays a pivotal role in numerous cellular processes. To advance our comprehension of gene regulatory networks, it is essential to develop computational tools for accurately identifying the subcellular localizations of mRNAs.

A data compression algorithm with the improved SRLE for high-throughput neural signal acquisition device.

Background: Multi-channel acquisition systems of brain neural signals can provide a powerful tool with a wide range of information for the clinical application of brain computer interfaces. High-throughput implantable systems are limited by size and power consumption, posing challenges to system design.

Objective: To acquire more comprehensive neural signals and wirelessly transmit high-throughput brain neural signals, a FPGA-based acquisition system for multi-channel brain nerve signals has been developed.

Evaluation of protective immunity induced by a DNA vaccine encoding SAG2 and SRS2 against Toxoplasma gondii infection in mice.

Toxoplasma gondii is an important protozoan pathogen, which can cause severe diseases in the newborns and immunocompromised individuals. Developing an effective vaccine against Toxoplasma infection is a critically important global health priority. Immunofluorescence staining analysis revealed that TgSAG2 and TgSRS2 are membrane associated and displayed on the surface of the parasite.

Revolutionizing motor dysfunction treatment: A novel closed-loop electrical stimulator guided by multiple motor tasks with predictive control.

Functional electrical stimulation (FES) has been demonstrated as a viable method for addressing motor dysfunction in individuals affected by stroke, spinal cord injury, and other etiologies. By eliciting muscle contractions to facilitate joint movements, FES plays a crucial role in fostering the restoration of motor function compromised nervous system. In response to the challenge of muscle fatigue associated with conventional FES protocols, a novel biofeedback electrical stimulator incorporating multi-motor tasks and predictive control algorithms has been developed to enable adaptive modulation of stimulation parameters.

A novel non-chemically amplified resist based on polystyrene-iodonium derivatives for electron beam lithography.

To break the resolution limitation of traditional resists, more work is needed on non-chemically amplified resists (non-CARs). Non-CARs based on iodonium salt modified polystyrene (PS-I) were prepared with controllable molecular weight and structure. The properties of the resist can be adjusted by the uploading of iodonium salts on the polymer chain, the materials with a higher proportion of iodonium salts show better lithography performance.

MERITS: a web-based integrated PE/PPE protein database.

Motivation: PE/PPE proteins, highly abundant in the genome, play a vital role in virulence and immune modulation. Understanding their functions is key to comprehending the internal mechanisms of . However, a lack of dedicated resources has limited research into PE/PPE proteins.

Genome-Wide Investigation of the PLD Gene Family in Tomato: Identification, Analysis, and Expression.

Phospholipase Ds (PLDs) are important phospholipid hydrolases in plants that play crucial roles in the regulation of plant growth, development, and stress tolerance. In this study, 14 PLD genes were identified in the tomato genome and were localized on eight chromosomes, and one tandem-duplicated gene pair was identified. According to a phylogenetic analysis, the genes were categorized into four subtypes: SlPLDα, β, and δ belonged to the C2-PLD subfamily, while SlPLDζ belonged to the PXPH-PLD subfamily.

Primary mature teratoma of the left adrenal gland: a case report.

Teratoma are germ cell tumors, most frequently arising in and retroperitoneal teratomas are rare, especially adrenal teratomas. Only a few case reports have been documented in the literature so far. We report the case of a 52-year-old asymptomatic male patient who had an incidental finding of a left adrenal teratoma during an abdominal computed tomography scan; due to the large size of the tumor, he underwent laparoscopic left adrenalectomy, and histopathological examination revealed a mature teratoma of the left adrenal gland, Patient recovering well after surgery and had no recurrence after 6 months of postoperative follow-up.

Recent advances in the precision control strategy of artificial pancreas.

The scientific diagnosis and treatment of patients with diabetes require frequent blood glucose testing and insulin delivery to normoglycemia. Therefore, an artificial pancreas with a continuous blood glucose (BG) monitoring function is an urgent research target in the medical industry. The problem of closed-loop algorithmic control of the BG with a time delay is a key and difficult issue that needs to be overcome in the development of an artificial pancreas.