RNF7-Mediated ROS Targets Malignant Phenotype and Radiotherapy Sensitivity in Glioma With Different IDH1 Genotypes.

RNF7 (Ring Finger Protein 7) is a key component of CRLs (Cullin-RING-type E3 ubiquitin ligases) and has been found to possess intrinsic anti-ROS capabilities. Aberrant expression of RNF7 has been observed in various tumor types and is known to significantly influence tumor initiation and progression. However, the specific role of RNF7 in glioblastoma remains unclear.

Effects of particle elongation on dense granular flows down a rough inclined plane.

Granular materials in nature are nearly always nonspherical, but particle shape effects in granular flow remain largely elusive. This study uses discrete element method simulations to investigate how elongated particle shapes affect the mobility of dense granular flows down a rough incline. For a range of systematically varied particle length-to-diameter aspect ratios (AR), we run simulations with various flow thicknesses h and slope angles θ to extract the well-known h_{stop}(θ) curves (below which the flow ceases) and the Fr-h/h_{stop} relations following Pouliquen's approach, where Fr=u/sqrt[gh] is the Froude number, u is the mean flow velocity, and g is the gravitational acceleration.

Lysosomal catabolic activity promotes the exit of murine totipotent 2-cell state by silencing early-embryonic retrotransposons.

During mouse preimplantation development, a subset of retrotransposons/genes are transiently expressed in the totipotent 2-cell (2C) embryos. These 2C transcripts rapidly shut down their expression beyond the 2C stage of embryos, promoting the embryo to exit from the 2C stage. However, the mechanisms regulating this shutdown remain unclear.

Experimental Research on the Performance of Recycled Waste Concrete Powder (RWCP) on Concrete.

Waste concrete is a large amount of solid waste produced in the process of urban construction and renewal in China. Its resource utilization is of great significance for saving mineral resources and improving urban environmental quality. The present study was designed to investigate the effects of mechanical grinding time on the particle size distribution and activity of recycled waste concrete powder (RWCP).

The pluripotent-to-totipotent state transition in mESCs activates the intrinsic apoptotic pathway through DUX-induced DNA replication stress.

The pluripotent mouse embryonic stem cell (mESCs) can transit into the totipotent-like state, and the transcription factor DUX is one of the master regulators of this transition. Intriguingly, this transition in mESCs is accompanied by massive cell death, which significantly impedes the establishment and maintenance of totipotent cells in vitro, yet the underlying mechanisms of this cell death remain largely elusive. In this study, we found that the totipotency transition in mESCs triggered cell death through the upregulation of DUX.

The roles of geometry and viscosity in the mobilization of coarse sediment by finer sediment.

In rivers, the addition of finer sediment to a coarser riverbed is known to increase the mobility of the coarser fraction. Two mechanisms have been suggested for this: a geometric mechanism whereby smaller sizes smooth the bed, increasing near-bed velocity and thus mobility of the larger sizes, and a viscous mechanism whereby a transitionally smooth turbulent boundary layer forms, rendering the coarser grains more mobile. Here, we report on experiments using two sediment mixtures to better understand these proposed mechanisms.

In-situ strategies for melamine-functionalized graphene oxide nanosheets-based nanocomposite proton exchange membranes in wide-temperature range applications.

The traditional preparation of nanocomposite proton exchange membranes (PEM) is hindered by poor organic-inorganic interface compatibility, insufficient proton-conducting sites, easy aggregation of nanoparticles, and difficulty in leveraging nanoscale advantages. In this study, a novel method involving electrochemical anodic oxidation exfoliation was employed to prepare melamine-coated graphene oxide (Me@GO), which was subsequently subjected to in-situ polymerization with poly(2,5-benzimidazole) (ABPBI) to prepare a Me@GO/ABPBI composite proton exchange membrane. Benefiting from the strong hydrogen bonding and large π stacking interactions, melamine (Me) tightly bound to graphene oxide (GO), effectively preventing the secondary aggregation of GO after exfoliation.

Salvaging the transected hypoglossal nerve using descendens hypoglossi in patients undergoing hypoglossal-facial nerve anastomosis for facial palsy: a randomized clinical trial.

Objective: Hypoglossal-facial nerve anastomosis (HFA) is the most commonly used surgical treatment for severe facial palsy that does not respond to conservative treatments. A major complication of HFA is the loss of tongue function. The authors aimed to evaluate whether anastomosing the transected hypoglossal nerve using the ramus descendens hypoglossi could prevent tongue deviation and dysfunction in patients undergoing HFA.

Establishment and validation of a bad outcomes prediction model based on EEG and clinical parameters in prolonged disorder of consciousness.

Objective: This study aimed to explore the electroencephalogram (EEG) indicators and clinical factors that may lead to poor prognosis in patients with prolonged disorder of consciousness (pDOC), and establish and verify a clinical predictive model based on these factors.

Methods: This study included 134 patients suffering from prolonged disorder of consciousness enrolled in our department of neurosurgery. We collected the data of sex, age, etiology, coma recovery scales (CRS-R) score, complications, blood routine, liver function, coagulation and other laboratory tests, resting EEG data and follow-up after discharge.

Revisit of Polyaniline as a High-Capacity Organic Cathode Material for Li-Ion Batteries.

Polyaniline (PANI) has long been explored as a promising organic cathode for Li-ion batteries. However, its poor electrochemical utilization and cycling instability cast doubt on its potential for practical applications. In this work, we revisit the electrochemical performance of PANI in nonaqueous electrolytes, and reveal an unprecedented reversible capacity of 197.

Quasi-Hyperbolic Framework Graphite Foam-Based Composites with High Thermal Conductivity and Electromagnetic Shielding Properties Fabricated by an Electrochemical Expansion Method.

Nowadays, the rapid development of electronic devices requires composites with high thermal conductivity and good electromagnetic shielding properties. The key challenge lies in the construction of high-performance conductive networks. Herein, an electrochemical expansion graphite foam (EEG) with a quasi-hyperbolic framework was prepared by an electrochemical expansion method, and then the epoxy resin (EP) was filled to fabricate the composites.

Mitophagy defect mediates the aging-associated hallmarks in Hutchinson-Gilford progeria syndrome.

Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal disease manifested by premature aging and aging-related phenotypes, making it a disease model for aging. The cellular machinery mediating age-associated phenotypes in HGPS remains largely unknown, resulting in limited therapeutic targets for HGPS. In this study, we showed that mitophagy defects impaired mitochondrial function and contributed to cellular markers associated with aging in mesenchymal stem cells derived from HGPS patients (HGPS-MSCs).

Advances in ionogels for proton-exchange membranes.

To ensure the long-term performance of proton-exchange membrane fuel cells (PEMFCs), proton-exchange membranes (PEMs) have stringent requirements at high temperatures and humidities, as they may lose proton carriers. This issue poses a serious challenge to maintaining their proton conductivity and mechanical performance throughout their service life. Ionogels are ionic liquids (ILs) hybridized with another component (such as organic, inorganic, or organic-inorganic hybrid skeleton).

Image Recognition and Parameter Analysis of Concrete Vibration State Based on Support Vector Machine.

In this paper, the directional gradient histogram technology is employed to extract the features of concrete image samples captured under different vibration states. The support vector machine (SVM) is utilized to learn the relationship between image features and vibration state. The machine learning results are subsequently used to assess the feasibility of the concrete vibration state.

Comparison of Two Representative Methods for Differentiation of Human Induced Pluripotent Stem Cells into Mesenchymal Stromal Cells.

Mesenchymal stromal cells (MSCs) are adult pluripotent stem cells which have been widely used in regenerative medicine. As somatic tissue-derived MSCs are restricted by limited donation, quality variations, and biosafety, the past 10 years have seen a great rise in efforts to generate MSCs from human induced pluripotent stem cells (hiPSCs). Past and recent efforts in the differentiation of hiPSCs into MSCs have been centered around two culture methodologies: (1) the formation of embryoid bodies (EBs) and (2) the use of monolayer culture.

Advancements and perspectives of RBX2 as a molecular hallmark in cancer.

Cancer is a challenging issue for human health. One of the key methods to address this issue is by comprehending the molecular causes of tumors and creating medications that target those causes. RBX2 (RING box protein 2), also known as ROC2 (Regulator of Cullins 2), RNF7 (RING Finger Protein 7), or SAG (Sensitive to Apoptosis Gene) is a key component of the Cullin-RING-type E3 ubiquitin ligases (CRLs) and overexpressed in various human cancers.

Effects of white matter hyperintensity on cognitive function in PD patients: a meta-analysis.

Background: Parkinson's disease (PD) is often accompanied by cognitive dysfunction, which imposes a heavy burden on patients, their families, and society. Early identification and intervention are particularly important, but reliable biomarkers for identifying PD-related cognitive impairment at an early stage are currently lacking. Although numerous clinical studies have investigated the association between brain white matter hyperintensity (WMH) and cognitive decline, the findings regarding the relationships between WMH and cognitive dysfunction in PD patients have been inconsistent.

Establishment risk of invasive golden mussel in a water diversion project: An assessment framework.

Inter-basin water diversion projects have led to accelerated colonization of aquatic organisms, including the freshwater golden mussel (), exacerbating global biofouling concerns. While the influence of environmental factors on the mussel's invasion and biofouling impact has been studied, quantitative correlations and underlying mechanisms remain unclear, particularly in large-scale inter-basin water diversion projects with diverse hydrodynamic and environmental conditions. Here, we examine the comprehensive impact of environmental variables on the establishment risk of the golden mussel in China's 1432-km-long Middle Route of the South-to-North Water Diversion Project.

Modeling feedback processes between soil detachment and sediment transport along hillslopes on the Loess Plateau of China.

A dynamic model of soil erosion along hillslopes considering soil detachment and sediment transport is still a major challenge in terms of its applicability to field conditions. Data availability for model calibration and validation is very limited for physically process models. An improved hillslope erosion dynamic model (HED) with a simple structure and strong application on field plots was established based on the sediment feedback mechanism in this study.

Multiple functions of stress granules in viral infection at a glance.

Stress granules (SGs) are distinct RNA granules induced by various stresses, which are evolutionarily conserved across species. In general, SGs act as a conservative and essential self-protection mechanism during stress responses. Viruses have a long evolutionary history and viral infections can trigger a series of cellular stress responses, which may interact with SG formation.

Reconstructed eight-century streamflow in the Tibetan Plateau reveals contrasting regional variability and strong nonstationarity.

Short instrumental streamflow records in the South and East Tibetan Plateau (SETP) limit understanding of the full range and long-term variability in streamflow, which could greatly impact freshwater resources for about one billion people downstream. Here we reconstruct eight centuries (1200-2012 C.E.