Publications by authors named "Xudan Peng"
Article Synopsis
- Tuberculosis (TB) is a serious global health issue, causing over 10.6 million new cases and 1.4 million deaths in 2021, worsened by the rise of drug-resistant strains like MDR-TB and XDR-TB.
- New compounds called BGAz, derived from a whole cell phenotypic screen, have shown strong bactericidal effects against both drug-sensitive and drug-resistant TB with no emerging drug resistance.
- These BGAz compounds work by disrupting the mycobacterial cell envelope and mycolic acid synthesis, showing a distinct action from current treatments, along with favorable toxicological and pharmacokinetic profiles for future chemotherapy development.
A library of substituted indolo[2,3-]quinolone-6-ones was developed as simplified Lamellarin isosters. Synthesis was achieved from indole after a four-step pathway sequence involving iodination, a Suzuki-Miyaura cross-coupling reaction, and a reduction/lactamization sequence. The inhibitory activity of the 22 novel derivatives was assessed on Haspin kinase.
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