Publications by authors named "Xuchao Shen"
Background: Primary central nervous system neuroblastoma (PCNSN) is a rare disease, and its incidence, treatment modalities, and survival remain poorly understood.
Methods: The SEER (Surveillance Epidemiology and End Results) database was used to identify patients diagnosed with PCNSN from 1973 to 2013. The incidence and survival rates were examined.
The tumor microenvironment is highly correlated with tumor occurrence, progress, and prognosis. We aimed to investigate the immune-related gene (IRG) expression and immune infiltration pattern in the tumor microenvironment of lower-grade glioma (LGG). We employed the Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE) algorithm to calculate immune and stromal scores and identify prognostic IRG based on The Cancer Genome Atlas data set.
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- A mutation in the IDH1 gene is common in diffuse lower-grade gliomas (LGGs) and significantly impacts patient prognosis.
- Researchers aimed to understand how the IDH1 mutation affects the immune microenvironment and created an immune prognostic signature (IPS) to predict outcomes in LGG patients.
- The study identified 41 immune-related genes linked to IDH1 status, leading to a four-gene IPS that effectively stratified patients into low- and high-risk groups, suggesting that the IPS could guide personalized treatment and improve survival predictions.