Publications by authors named "Xuboya Chang"
Advanced ovarian cancer often presents with multiple lesions exhibiting varying responses to chemotherapy, highlighting the critical influence of the tumor microenvironment (TME). This study investigates the phenomenon of chemotherapeutic hormesis, wherein low doses of chemotherapeutic agents, such as cisplatin (CDDP) and paclitaxel (PTX), paradoxically stimulate rather than inhibit cancer cell proliferation. Our findings indicate that NOS3 ovarian cancer cells, particularly drug-resistant variants, exhibit enhanced proliferation when exposed to low concentrations of these drugs.
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- * Methods such as phosphokinase arrays, RNA sequencing, and tumor assessments were utilized to investigate luteolin's effects, revealing it promotes apoptosis and halts cell proliferation by activating the p53 signaling pathway.
- * Results showed that luteolin significantly reduced tumor growth in patient-derived models and worked synergistically with cisplatin, indicating its potential as a beneficial cotreatment option for HGSOC patients.
Aim: Malignant transformation of mature cystic teratoma (MTMCT) of the ovary is a rare gynecological malignancy and commonly arises in women older than 50 years of age. The most common histological type of MTMCT is squamous cell carcinoma (SCC), and the prognosis is extremely poor. Patient-derived xenograft (PDX) models are promising animal models for preclinical drug screening.
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