Nanozymes are nano-catalysis materials with enzyme-like activities, which can repair the defects of natural enzyme such as harsh catalytic conditions, and harness their strengths to treat tumor. The emerging nanodynamic therapies improved drug selectivity and decreased drug tolerance, while causing efficient cell apoptosis through the generated reactive oxygen species (ROS). Nanodynamic therapies based on nanozymes can improve the complicated tumor microenvironment (TME) to reduce the defect rate of nanodynamic therapies, and provide more options for tumor treatment.
View Article and Find Full Text PDFClassical swine fever (CSF) still threatens the swine industry in China, with genotype 2 isolates of CSFV dominating the epizootics. In 2018 the first E2 subunit marker vaccine against CSFV (Tian Wen Jing, TWJ-E2®), containing a baculovirus-expressed E2 glycoprotein of a genotype 1.1 vaccine strain, was officially licensed in China and commercialized.
View Article and Find Full Text PDFClassical swine fever (CSF) remains an important pig disease in China, where it usually presents with mild or atypical clinical manifestations, with large scale outbreaks rarely seen. This has led to speculation about the possible circulation of viral strains of low virulence. To investigate this possibility, five field isolates within the predominant genotype 2 (2.
View Article and Find Full Text PDFWei Sheng Wu Xue Bao
June 2003
A novel radiation-resistant bacterium was isolated from soil of lake bank in Beijing. The bacterium produced orange-pigmented colonies and formed rod-shaped cells that stained gram negative alike the Deinobacter grandis previously described by Japan's scientist. It was found with electron microscopy that the isolate is of 0.
View Article and Find Full Text PDFWei Sheng Wu Xue Bao
April 2005
The activity of protease from Deinococcus radiodurans R1 (DRR1) recovered from UV light and gamma-ray irradiation were characterized by SDS-PAGE zymography or FITC-labeled casein as substrate. It was demonstrated that proteases with large molecular weight were abundantly and constitutively expressed in DRR1, which consistent with the hypothesis that proteases were among the PHX (predicted highly expressed) proteins in DRR1. A broad range of gelatinolytic protease with molecular mass more than 140 kD and caseinolytic protease with molecular mass more than 120 kD were present in DRR1 cell.
View Article and Find Full Text PDFMitosin/CENP-F is a human nuclear matrix protein with multiple leucine zipper motifs. Its accumulation in S-G2 phases and transient kinetochore localization in mitosis suggest a multifunctional protein for cell proliferation. Moreover, its murine and avian orthologs are implicated in myocyte differentiation.
View Article and Find Full Text PDFThe variable number of tandem repeat (VNTR) polymorphism in the intron 6 of the human telomerase reverse transcriptase(hTERT) was investigated. Seven alleles of 18, 20, 21, 22, 23, 26 and 35 repeats of the 36 bp VNTR6-1st and 14 genotypes were identified among 210 unrelated healthy Chinese individuals (Han people) living in Beijing. The 20, 22 and 35 repeats were the most frequent alleles which accounted for 94.
View Article and Find Full Text PDFPolymorphism of the (CCTTT)n repeat, a short tandem repeats (STR) located in promoter region of the inducible nitric oxide synthase (iNOS) gene, was analyzed in a total of 316 Chinese healthy subjects. Twelve alleles and forty-nine genotypes were identified. Three alleles that had not been reported previously, namely 17-repeats, 18-repeats and 19-repeats, were found in Chinese population.
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