Luoshi Neiyi Prescription inhibits estradiol synthesis and inflammation in endometriosis through the HIF1A/EZH2/SF-1 pathway.

Ethnopharmacological Relevance: Endometriosis (EMS) is a common gynecological disease that causes dysmenorrhea, chronic pelvic pain and infertility. Luoshi Neiyi Prescription (LSNYP), a traditional Chinese medicine (TCM) formula, is used to relieve EMS in the clinic.

Aims: This study aimed to examine the active components of LSNYP and the possible mechanism involved in its treatment of EMS.

IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer.

Chemotherapy-resistant non-small cell lung cancer (NSCLC) presents a substantial barrier to effective care. It is still unclear how cancer-associated fibroblasts (CAFs) contribute to NSCLC resistance to chemotherapy. Here, we found that CD248 CAFs released IL-8 in NSCLC, which, in turn, enhanced the cisplatin (CDDP) IC50 in A549 and NCI-H460 while decreasing the apoptotic percentage of A549 and NCI-H460 in vitro.

Solving patient referral problems by using bat algorithm.

Background: A two-hospital patient referral problem intends to calculate an optimal value of referral patients between two hospitals and to evaluate whether or not the current number of referral patients is too low.

Objective: The goal of this study is to develop a simulation-based optimization algorithm to find the optimal referral between two hospitals with the unfixed daily patient referral policy.

Methods: This study applied system simulation and a bat algorithm (BA) to build a simulation model in accordance with the status of the two hospitals case and to calculate an optimal value of daily referral patients.

A bio-inspired optical system with a polymer membrane and integrated structure.

A bio-inspired optical imaging system with a polymer membrane and integrated structure is proposed. Similar to the human eye, the presented system has a biomimetic multilayered optical structure and utilizes a solid-liquid mixed tunable lens as the variable-focus unit. The focal length of the imaging system can be adjusted flexibly through the deformation of the tunable lens when it is compressed.

Investigation on wind energy-compressed air power system.

Wind energy is a pollution free and renewable resource widely distributed over China. Aimed at protecting the environment and enlarging application of wind energy, a new approach to application of wind energy by using compressed air power to some extent instead of electricity put forward. This includes: explaining the working principles and characteristics of the wind energy-compressed air power system; discussing the compatibility of wind energy and compressor capacity; presenting the theoretical model and computational simulation of the system.