Publications by authors named "Xuanyi Liu"

Background: Doxorubicin (DOX), a widely employed chemotherapeutic agent in cancer treatment, has seen restricted use in recent years owing to its associated cardiotoxicity. Current reports indicate that doxorubicin-induced cardiotoxicity (DIC) is a complex phenomenon involving various modes of cell death. Astaxanthin (ASX), a natural carotenoid pigment, has garnered significant attention for its numerous health benefits.

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In recent decades, Offshore Wind Turbines (OWTs) have become crucial to the clean energy transition, yet they face significant safety challenges due to harsh marine conditions. Key issues include blade damage, material corrosion, and structural degradation, necessitating advanced materials and real-time monitoring systems for enhanced reliability. Carbon fiber has emerged as a preferred material for turbine blades due to its strength-to-weight ratio, although its high cost remains a barrier.

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Article Synopsis
  • The study investigates juvenile dermatomyositis (JDM), a rare autoimmune disease affecting children, focusing on its epidemiological characteristics and economic impact in China.
  • Data from 1,164 JDM patients across 24 hospitals indicated a gender ratio of 1:1.23 and revealed that over half of the patients required multiple hospitalizations, with significant lung involvement being the most common complication.
  • The findings highlight the severity and social burden of JDM in China, providing crucial insights for better management and understanding of the disease.
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: Perfluorooctane sulfonate (PFOS) is a persistent, widely present environmental pollutant, and its toxicity to male reproduction has gradually attracted attention. Flaxseed oil (FO) is a dietary oil abundant in α-linolenic acid and has been demonstrated to possess multiple health benefits. However, whether FO protects against PFOS-induced testicular injury and its mechanism remain unclear.

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Objectives: In recent years, the distinct clinical presentations and elevated mortality rates of various subtypes of juvenile idiopathic arthritis (JIA) with pulmonary involvement have garnered significant attention. This study aimed to elucidate the clinical characteristics of pulmonary involvement in patients with JIA to improve clinicians' knowledge.

Methods: This single-centre retrospective study analysed the baseline data, treatment options, follow-up of sixty patients of JIA with pulmonary involvement in China.

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Exosomes are extracelluar vesicles that facilitate intercellular communication and are pivotal in post-transcriptional regulation within cellular gene regulatory networks, impacting pathogen dynamics. These vesicles serve as crucial regulators of immune responses, mediating cellular interactions and enabling the introduction of viral pathogenic regions into host cells. Exosomes released from virus-infected cells harbor diverse microRNAs (miRNAs), which can be transferred to recipient cells, thereby modulating virus infection.

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Silicon photonics devices benefit greatly from a partially etched platform and inverse design. Herein, we propose a bi-layer polarization splitter and rotator with a topology pattern and demonstrate it on a silicon-on-insulator platform. Our device exhibits a significantly reduced physical footprint of only 2µ×6µ, compared to traditional directional couplers and tapered waveguides.

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Introduction: Sepsis is a worldwide epidemic, with high morbidity and mortality. Cuproptosis is a form of cell death that is associated with a wide range of diseases. This study aimed to explore genes associated with cuproptosis in sepsis, construct predictive models and screen for potential targets.

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Background And Aims: Radiotherapy is widely applied for lung adenocarcinoma (LUAD), while individualized differences led to different outcomes. This study aimed to establish a multi-gene risk scoring model to predict the benefits of LUAD patients from radiotherapy, based on different types of cell death respectively.

Results: Other than autophagy, pyroptosis, ferroptosis and Immunogenic cell death (ICD), the LUAD prognostic model based on apoptosis had the best performance, and the area under curves (AUCs) of the receiver operating curve (ROC) for 1-, 3-, and 5-year OS were 0.

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A highly efficient second-harmonic source is integrated into a silicon nitride microring resonator, unlocking the potential for advanced chip-scale devices such as miniaturized atomic clocks and fully integrated self-referenced microcombs.

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: Fine particulate matter (PM), a small molecule particulate pollutant, can reach the lungs respiration and cause lung damage. Currently, effective strategies and measures are lacking to prevent and treat the pulmonary toxicity of PM. Astaxanthin (ASX), a natural xanthophyll carotenoid, has attracted attention due to its unique biological activity.

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All polarization-maintaining (PM) linear cavity mode-locked fiber lasers are promising ultrafast laser sources due to their compactness and environmental robustness. Here, we demonstrate a linear cavity fiber laser with all-PM configuration experimentally and investigate the mode-locking formation of the laser using a machine-learning iterative optimization method based on the Gaussian process. The optimization algorithm can converge rapidly after only 30 runs.

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In mode-locked fiber lasers, the formation of ultrashort pulses from noisy or unstable states is a crucial area of research. Investigating these complex nonlinear dynamics can lead to valuable insights and new practical engineering techniques, particularly for the design and optimization of optical systems. Time-stretch dispersive Fourier transform, utilized in our study to investigate dissipative solitons formation in a net-normal dispersion nonlinear polarization evolution mode-locked fiber laser, provides a window into the intricate dynamics of such systems.

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Article Synopsis
  • A stable and low-noise all-polarization-maintaining (PM) ultrafast erbium-doped fiber laser has been developed, featuring a dual-output structure and self-starting mode-locking via a non-reciprocal phase shifter.
  • The all-PM configuration increases resistance to environmental changes, while the dual-output enables enhanced optical properties through intracavity filtering.
  • The laser produces ultrashort pulses of 129 fs at a repetition rate of 105.8 MHz, with minimal noise and stable performance confirmed over a 25-hour period.
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Epsilon-near-zero (ENZ) materials have attracted great interest due to their exotic linear and nonlinear responses, which makes it significant to tune ENZ wavelengths for wavelength-dependent applications. However, studies to achieve tunability in a wide spectral range and link the fabrication parameters with linear and nonlinear ENZ properties have been uncovered. ENZ indium tin oxide (ITO) nanofilms are fabricated by magnetron sputtering, through which the control of ENZ properties is demonstrated.

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Objective: The anti-MDA5 (anti-melanoma differentiation associated gene 5) antibody is often associated with a poor prognosis in juvenile dermatomyositis (JDM) patients. In many developing countries, there is limited ability to access myositis- specific antibodies due to financial and technological issues, especially in remote regions. This study was performed to develop a prediction model for screening anti-MDA5 antibodies in JDM patients with commonly available clinical findings.

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Background: This study determined the effects of the paternal dietary ratio of n-6: n-3 polyunsaturated fatty acids (PUFAs) on leptin expression in the offspring and associated gene imprinting in a mouse model.

Methods: Three- to four-week-old male C57BL/6J mice (F0) were fed an n-3 PUFA-deficient (n-3 D) diet, a diet with normal n-3 PUFA content (n-3 N; n-6: n-3 = 4.3:1), or a diet with a high n-3 PUFA content (n-3 H; n-6: n-3 = 1.

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Recent studies demonstrate that paternal nutrition prior to conception may determine offspring development and health through epigenetic modification. This study aims to investigate the effects of paternal supplementation of n-3 polyunsaturated fatty acids (n-3 PUFAs) on the brain development and function, and associated gene imprinting in the offspring. Three to four-week-old male C57BL/6J mice (founder) were fed with an n-3 PUFA-deficient diet (n-3 D), and two n-3 PUFA supplementation diets - a normal n-3 PUFA content diet (n-3 N) and a high n-3 PUFA content diet (n-3 H) for 12 weeks.

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Silicon photonics enables compact integrated photonic devices with versatile functionalities and mass manufacturing capability. However, the optimization of high-performance free-form optical devices is still challenging due to the complex light-matter interaction involved that requires time-consuming electromagnetic simulations. This problem becomes even more prominent when multiple devices are required, typically requiring separate iterative optimizations.

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Few studies have investigated the correlation between maternal polyunsaturated fatty acids (PUFAs) and telomeres in offspring, and the underlying influential mechanisms. In this study, we assessed the associations of maternal PUFAs with telomere length (TL) and DNA methylation of the telomerase reverse transcriptase (TERT) promoter in the cord blood and the placenta. A total of 274 pregnant women and their newborn babies were enrolled in this study.

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Objective: The observation study sought to explore the influencing factors associated with mobile phone use when e-cyclists were waiting for red lights at intersections, which provided a theoretical foundation for solving the potential traffic threat and developing management plans for e-cyclists.

Methods: Data regarding e-cyclists were collected through camera conducted at the entrance of multiple intersections in Zhenjiang, China in July 2020. The data was reviewed by playing frame by frame.

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We introduce supercritical fluid (SCF) technology to epsilon-near-zero (ENZ) photonics for the first time and experimentally demonstrate the manipulation of the ENZ wavelength for the enhancement of linear and nonlinear optical absorption in ENZ indium tin oxide (ITO) nanolayer. Inspired by the SCF's applications in repairing defects, reconnecting bonds, introducing dopants, and boosting the performance of microelectronic devices, here, this technique is used to exploit the influence of the electronic properties on optical characteristics. By reducing oxygen vacancies and electron scattering in the SCF oxidation process, the ENZ wavelength is shifted by 23.

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Objectives: Juvenile dermatomyositis (JDM) is an autoimmune disease characterised by a great heterogeneity in its clinical manifestations. In this study, we aimed to investigate the association between different clinical subtypes, laboratory data, and myositis antibodies of JDM.

Methods: A total of 132 JDM patients were enrolled and their medical records were retrospectively reviewed and autoantibodies tested.

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A novel fiber Michelson interferometer (FMI) based on parallel dual polarization maintaining fiber Sagnac interferometers (PMF-SIs) is proposed and experimentally demonstrated for temperature sensing. The free spectral range (FSR) difference of dual PMF-SIs determines the FSR of envelope and sensitivity of the sensor. The temperature sensitivity of parallel dual PMF-SIs is greatly enhanced by the Vernier effect.

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Background: Telomeres play a crucial role in cellular survival and its length is a predictor for onset of chronic non-communicable diseases. Studies on association between telomeres and obesity in children have brought discrepant results and the underlying mechanisms and influential factors are to be elucidated. This study aimed to investigate changes in telomere length and telomerase reverse transcriptase (TERT) DNA methylation, and further to determine their correlation with n-3 polyunsaturated fatty acids (PUFAs) in preschool children with obesity.

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