Inhibition of GSDMD-mediated pyroptosis triggered by Trichinella spiralis intervention contributes to the alleviation of DSS-induced ulcerative colitis in mice.

Background: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is increasing worldwide. Although there is currently no completely curative treatment, helminthic therapy shows certain therapeutic potential for UC. Many studies have found that Trichinella spiralis (T.

Virulence-related gene wx2 of Toxoplasma gondii regulated host immune response via classic pyroptosis pathway.

Background: Toxoplasma gondii is known as the most successful parasite, which can regulate the host immune response through a variety of ways to achieve immune escape. We previously reported that a novel gene wx2 of T. gondii may be a virulence-related molecule.

Epitope vaccine design for Toxoplasma gondii based on a genome-wide database of membrane proteins.

Background: There is presently no effective and safe vaccine for Toxoplasma gondii for humans. The study described here was designed to search for a novel group of optimal B cell and T cell epitopes from Toxoplasma membrane proteins using genome-wide comprehensive screening.

Methods: The amino acid sequences of membrane proteins of T.

Corrigendum: A Novel Gene of Inhibits the Parasitic Invasion and Proliferation and Attenuates Virulence via Immune Response Modulation.

[This corrects the article DOI: 10.3389/fmicb.2020.

A Novel Gene of Inhibits the Parasitic Invasion and Proliferation and Attenuates Virulence via Immune Response Modulation.

() is an obligate intracellular apicomplexan protozoan that can parasitize most warm-blooded animals and cause severe diseases in immunocompromised individuals or fetal abnormalities in pregnant woman. The treatment of toxoplamosis has been limited by effective drugs. Our previous work indicated that the novel gene of may serve as a vaccine antigen candidate.

Bioinformatics of excretory/secretory proteins of Toxoplasma gondii strain ME49.

Toxoplasma gondii is an obligate intracellular parasite that is globally distributed and can infect almost all warm-blooded animals, including humans. While vaccines are not available for prophylaxis, there are limited therapeutic options which often do not result in eradication of parasites from patients. ME49 is a cystogenic strain of T.