Design, synthesis, biological evaluation and molecular docking of novel isatin-oxime ether derivatives as potential IDH1 inhibitors.

A series of novel isatin-oxime ether derivatives were designed, synthesized and characterized by H NMR and C NMR and HRMS. These compounds were evaluated for their in vitro cytotoxicity against three human cancer cell lines (A549, HepG2 and Hela) by MTT assay. According to the experimental results, compounds 6a (IC = 0.

Recent advances in C-F bond activation of trifluoromethylated carbonyl compounds and derivatives.

The selective activation of inert C-F bonds is one of the most challenging topics in modern organic chemistry. Trifluoromethylketones represent a class of versatile building blocks that are inexpensive and readily available polyfluorinated starting materials. The functionalization of C-F bond in trifluoromethylketones has recently been achieved using difluoroenolates, difluorinated acyl anions or radicals for the synthesis of difluoromethylene compounds.