Publications by authors named "Xuanfu Wu"
Free Radic Biol Med
October 2024
Article Synopsis
- Ferroptosis is a new type of cell death linked to neurological diseases, and the study identifies sulfiredoxin-1 (SRXN1) as a key regulator that makes cells more susceptible to this process when exposed to the drug erastin.*
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- The research utilized TMT-based proteomics to show that erastin increases SRXN1 levels in HT-22 mouse hippocampal cells, and knocking down SRXN1 reduces the ferroptosis induced by erastin by lowering intracellular Fe and reactive oxygen species (ROS).*
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- The study highlights that the activation of Heme Oxygenase-1 (HO-1) is vital for SRXN1 expression and suggests that targeting the SRXN1
