Searching for perturbed biological pathways and genes through analyzing the expression profile changes in osteoclasts after treatment by bisphosphonates.

Criticality pathways and genes related to osteoporosis were identified. We downloaded the expression data of osteoclasts treated with or without bisphosphonates and all human pathways from the public database. Gibbs sampling and Markov chain were performed to identify the disturbed pathways and the hub genes in the disturbed pathways.

[The correlation between the level of serum VEGF and bFGF with metastasis and prognosis of osteosarcoma].

Aim: To investigate the correlation between the level of serum VEGF and bFGF with metastasis and re- currence of osteosarcoma.

Methods: 52 patients with osteosarcoma and 60 healthy people as control group were selected. The serum contents of VEGF and bFGF were determined with ELISA before and after operation.

[Preliminary clinical study on the posterior lumbar minimally invasive surgery assisted by 3D-Viewer system under a direct vision].

Objective: To study the methods and preliminary clinical efficacy of posterior lumbar minimally invasive surgery assisted by 3D-Viewer system under a direct vision and provide rationales for further clinical applications.

Methods: From September 2008 to September 2009, a total of 84 lumbar degenerative disease patients were enrolled and randomly divided into 2 groups (n = 42 each). One group was treated operatively by 3D-Viewer system under a direct vision while another treated with conventional operations.

[Metrx quadrant system in the surgery of lumbar spondylolisthesis: preliminary clinical application].

Objective: To evaluate the clinical efficacy and minimal invasiveness of quadrant posterior distraction system in the posterior lumbar spondylolisthesis (LS) surgery.

Methods: Sixty-one LS patients were randomly divided into two groups: quadrant posterior minimally invasive surgery system as invasive group (n = 30) and traditional open surgery as open group (n = 31). The clinical outcome of pain relief was assessed by the scoring systems of visual analogue scale (VAS) and Oswestry disability index (ODI) for low back pain.