Publications by authors named "Xuan-Xuan Huang"
Article Synopsis
- Cerebral-cardiac syndrome (CCS) refers to cardiac damage caused by ischemic stroke, linked to macrophages, but their varying roles are not well understood.
- A mouse model of ischemic stroke revealed that heart damage was marked by significant heart dysfunction and increased infiltration of proinflammatory monocyte-derived macrophages.
- The study indicates that activated cardiac sympathetic nerves promote macrophage infiltration in the heart, which may contribute to the cardiac dysfunction seen in CCS, suggesting a possible mechanism linking these elements.
Article Synopsis
- Subarachnoid hemorrhage (SAH) can severely impact not only the brain but also the heart, leading to significant cardiac injuries in mice, such as extended QT intervals and reduced heart function.
- Researchers found that increased galectin-3 expression was linked to these cardiac issues and could be reversed with the galectin-3 inhibitor TD139.
- Additional findings showed that suppressing macrophage activation with propranolol improved heart function and reduced galectin-3 levels, indicating a potential therapeutic target through a macrophage-galectin-3 pathway for SAH-related cardiac problems.
Ischaemic stroke is a severe disease worldwide. Restoration of blood flow after ischaemic stroke leads to cerebral ischaemia-reperfusion injury (CIRI). Various operations, such as cardiac surgery with deep hypothermic circulatory arrest, predictably cause cerebral ischaemia.
View Article and Find Full Text PDFBackground: To develop an effective model of predicting fatal outcomes in the severe coronavirus disease 2019 (COVID-19) patients.
Methods: Between February 20, 2020 and April 4, 2020, consecutive confirmed 2541 COVID-19 patients from three designated hospitals were enrolled in this study. All patients received chest computed tomography (CT) and serological examinations at admission.
The effects of gentiopicroside (Gent), an active component derived from the traditional Chinese medicine Gentiana macrophylla, on lipopolysaccharide-induced astrocyte activation and subsequent neuronal damage were investigated. Gent significantly inhibited the release of tumor necrosis factor-α, interleukin-1β, nitric oxide, and prostaglandin E, as well as expressions of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-induced primary astrocytes. Furthermore, Gent relieved neurotoxicity from astrocyte-mediated inflammatory injury.
View Article and Find Full Text PDFObjective: This randomized controlled study investigated the feasibility of early ambulation after liver resection and the effect of the amount of activity on postoperative recovery.
Methods: A total of 120 patients who underwent liver resection were randomly divided into two groups for the comparative analysis of the following factors: amount of activity, pain control, sleeping state, perioperative gastrointestinal function recovery, incidence of complications and postoperative hospital stay.
Results: Compared with the control group, patients undergoing liver resection performing early postoperative ambulation had faster gastrointestinal function recovery (First exhaust time 2.