Calcium signaling triggers early high humidity responses in .

Plants need to adapt to fluctuating atmospheric humidity and respond to both high and low humidity. Despite our substantial understanding of plant responses to low humidity, molecular mechanisms underlying the high humidity (HH) response are much less well understood. In this study, we investigated early responses to HH in .

Changes in Serum Rheumatoid Factor Following Eradication of Hepatitis C Virus Infection With Interferon or Direct Antiviral Therapy.

Hepatitis C virus (HCV) infection is associated with a myriad of extrahepatic manifestations (EHM), as well as the production of autoantibodies, including rheumatoid factor (RF). This study aims to elucidate whether serum levels of RF change before and after HCV eradication, and whether these changes differ according to the type of therapy used. This is a retrospective cohort study of adults with chronic HCV infection treated with interferon-free or interferon-based regimens.

The impact of oxidation-reduction potential in follicular fluid on intracytoplasmic sperm injection outcomes.

Objective: Follicular fluid (FF) oxidation-reduction potential (ORP) has shown promise as a predictor for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes has been demonstrated. This study aimed to determine the association between the ORP in FF and IVF/ICSI outcomes.

Methods: This cross-sectional study involved data collection from 341 couples undergoing IVF/ICSI treatment.

Recurrence Rate and Associated Factors of Primary Fallopian Tube Carcinoma in the South of Vietnam.

Objectives: This study aimed to determine the recurrence rate and related risk factors of primary fallopian tube cancer (PFTC).

Materials And Methods: We conducted a retrospective study of 47 patients with histopathological diagnosis of PFTC treated at Tu Du Hospital between January 1, 2015, and July 31, 2022. The cumulative recurrence rate was estimated using the life table method, and recurrence-associated factors were determined using the Log-rank test and Cox proportional hazard model.

Effects of COVID-19 virus-like particles on the behavioral and cognitive performance of human apolipoprotein E targeted replacement mice.

Introduction: The effects of viral infections might be apolipoprotein E (apoE) isoform-dependent. In humans, there are three major apoE isoforms, E2, E3, and E4. E4 is associated with the enhanced entry of several viruses into the brain and their disease progression.

Bridging human and machine intelligence: Reverse-engineering radiologist intentions for clinical trust and adoption.

In the rapidly evolving landscape of medical imaging, the integration of artificial intelligence (AI) with clinical expertise offers unprecedented opportunities to enhance diagnostic precision and accuracy. Yet, the "black box" nature of AI models often limits their integration into clinical practice, where transparency and interpretability are important. This paper presents a novel system leveraging the Large Multimodal Model (LMM) to bridge the gap between AI predictions and the cognitive processes of radiologists.

Bridging the Gap between Dermatology and Psychiatry: A Review on Quality of Life in Trichotillomania and Special Considerations in Management.

Background: Trichotillomania (TTM), also known as hair pulling disorder, is a chronic disorder that often leads to considerable emotional distress and functional impairment in affected individuals. Despite the strong underlying psychiatric component of TTM, the majority of individuals suffering from TTM initially may present to dermatologists because of their hair loss. This necessitates awareness and early recognition of TTM as well as familiarity with the unique considerations for its management.

Mental health literacy and the public perception of persons with depression and schizophrenia in Vietnam.

Background: Vietnam's mental health care system is undergoing significant changes since the government has initiated large-scale programs to reform and develop the mental health care infrastructure. Cultural belief systems on mental illnesses influence help-seeking behavior and compliance. This study investigates the belief systems about people with schizophrenia and depression among people living in the Hanoi area.

Corrigendum to "Differential efficacy of medical therapies for ulcerative colitis according to disease extent: patient-level analysis from multiple randomized controlled trials" volume 72, 102621.

[This corrects the article DOI: 10.1016/j.eclinm.

Factors Associated With Delayed Hospital Arrival After Stroke Onset: An Observational Study in Thanh Hoa Province, Vietnam.

Background: Delayed hospital arrival lowers the proportion of patients with stroke receiving recanalization therapy and results in poor outcomes. This study investigated the factors associated with pre-hospital delays in hospital arrival after stroke onset in the Thanh Hoa Province, Vietnam.

Methods: Clinical data were collected from stroke patients within seven days of symptom onset who were prospectively registered in this study.

ColonNeXt: Fully Convolutional Attention for Polyp Segmentation.

This study introduces ColonNeXt, a novel fully convolutional attention-based model for polyp segmentation from colonoscopy images, aimed at the enhancing early detection of colorectal cancer. Utilizing a purely convolutional neural network (CNN), ColonNeXt integrates an encoder-decoder structure with a hierarchical multi-scale context-aware network (MSCAN) in the encoder and a convolutional block attention module (CBAM) in the decoder. The decoder further includes a proposed CNN-based feature attention mechanism for selective feature enhancement, ensuring precise segmentation.

Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy.

Ionizable lipids are a key component of lipid nanoparticles, the leading nonviral messenger RNA delivery technology. Here, to advance the identification of ionizable lipids beyond current methods, which rely on experimental screening and/or rational design, we introduce lipid optimization using neural networks, a deep-learning strategy for ionizable lipid design. We created a dataset of >9,000 lipid nanoparticle activity measurements and used it to train a directed message-passing neural network for prediction of nucleic acid delivery with diverse lipid structures.

Long G4-rich enhancers target promoters via a G4 DNA-based mechanism.

Several studies have now described instances where G-rich sequences in promoters and enhancers regulate gene expression through forming G-quadruplex (G4) structures. Relatedly, our group recently identified 301 long genomic stretches significantly enriched for minimal G4 motifs (LG4s) in humans and found the majority of these overlap annotated enhancers, and furthermore, that the promoters regulated by these LG4 enhancers are similarly enriched with G4-capable sequences. While the generally accepted model for enhancer:promoter specificity maintains that interactions are dictated by enhancer- and promoter-bound transcriptional activator proteins, the current study tested an alternative hypothesis: that LG4 enhancers interact with cognate promoters via a direct G4:G4 DNA-based mechanism.

Harnessing extracellular vesicle-mediated crosstalk between T cells and cancer cells for therapeutic applications.

Small extracellular vesicles (EVs) are a diverse group of lipid-based particles that are ≤200 nm in diameter and contain an aqueous core. EVs have been shown to mediate intercellular communications between a wide array of immune cells; the downstream effects are diverse and have potential implications for the development of novel immunotherapeutic treatments. Despite a high volume of studies addressing the role EVs play in the immune system, our understanding of the crosstalk between T cells and cancer cells remains limited.

High resistance barrier and prophylactic protection in preclinical models of SARS-CoV-2 with two siRNA combination.

RNA interference is a natural antiviral mechanism that could be harnessed to combat SARS-CoV-2 infection by targeting and destroying the viral RNA. We identified potent lipophilic small interfering RNA (siRNA) conjugates targeting highly conserved regions of SARS-CoV-2 outside of the spike-encoding region capable of achieving ≥3-log viral reduction. Serial passaging studies demonstrated that a two-siRNA combination prevented development of resistance compared to a single siRNA approach.

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuit.

Metastatic castrate-resistant prostate cancer (mCRPC) is a genetically and phenotypically heterogeneous cancer where advancements are needed in biomarker discovery and targeted therapy. A critical and often effective component of treatment includes taxanes. We perform a high-throughput screen across a cohort of 30 diverse patient-derived castrate-resistant prostate cancer (CRPC) organoids to a library of 78 drugs.

Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C-MHC I complex Demonstrates the Antitumor Efficacy of Hapten-Based Strategies.

Antibody-based therapies have emerged as a powerful strategy for the management of diverse cancers. Unfortunately, tumor-specific antigens remain challenging to identify and target. Recent work established that inhibitor-modified peptide adducts derived from KRAS G12C are competent for antigen presentation via MHC I and can be targeted by antibody-based therapeutics, offering a means to directly target an intracellular oncoprotein at the cell surface with combination therapies.

Identification of novel variants of and genes in xeroderma pigmentosum patients in Vietnam.

Xeroderma pigmentosum (XP) disorder is recognized as a genetic condition inherited by autosomal recessive fashion. XP results from a defective DNA repair mechanism that significantly increases skin cancer risk. Fifteen Vietnamese patients were investigated with typical clinical manifestations of XP.