Publications by authors named "Xuan-Jie Yu"
Article Synopsis
- Gastric cancer (GC) is a common and serious disease, prompting a need for new treatments due to the limitations of conventional methods like radiotherapy and chemotherapy.
- Traditional Chinese Medicine (TCM) is gaining attention for its low toxicity and ability to target multiple pathways, making it a potential alternative in GC therapy.
- Recent research shows that TCM can effectively combat GC by inhibiting tumor growth, inducing cell death, and enhancing the effectiveness of existing chemotherapy, suggesting a bright future for its use in treatment strategies.
Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) is difficult to treat with radioactive iodine because of the absence of the sodium iodide transporter in the basement membrane of thyroid follicular cells for iodine uptake. This is usually due to the mutation or rearrangement of genes and the aberrant activation of signal pathways, which result in abnormal expression of thyroid-specific genes, leading to resistance of differentiated thyroid cancer cells to radioiodine therapy. Therefore, inhibiting the proliferation and growth of RAIR-DTC with multikinase inhibitors and other drugs or restoring its differentiation and then carrying out radioiodine therapy have become the first-line treatment strategies and main research directions.
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