Publications by authors named "Xuan-He You"

Article Synopsis
  • Creating a bone regeneration microenvironment that harmonizes bone formation and immune responses is complicated, but researchers developed a bacterial cellulose scaffold (FOBS) to tackle this challenge.
  • The scaffold features chemically modified cellulose that enhances bonding with dopamine and promotes calcium and phosphate deposition, leading to a significant increase in hydroxyapatite content.
  • FOBS not only shifts the immune environment from M1 to M2 macrophages, which are more favorable for healing, but also boosts the osteogenic differentiation of stem cells, as shown in animal studies.
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Cellulose-based polymer scaffolds are highly diverse for designing and fabricating artificial bone substitutes. However, realizing the multi-biological functions of cellulose-based scaffolds has long been challenging. In this work, inspired by the structure and function of the extracellular matrix (ECM) of bone, we developed a novel yet feasible strategy to prepare ECM-like scaffolds with hybrid calcium/zinc mineralization.

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Background: Postoperative chylothorax is usually regarded as a complication associated with cardiothoracic surgery; however, it is one of the rare complications in orthopedic surgery. This case report describes a female patient who developed chylothorax after a successful L4-S1 transforaminal lumbar interbody fusion surgery. The etiology, diagnosis, and treatment were analyzed and discussed.

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