Publications by authors named "Xuan-Chun Wang"
When a dry mass of certain amphiphiles encounters water, a spectacular interfacial instability ensues: It gives rise to the formation of ensembles of fingerlike tubular protrusions called myelin figures─tens of micrometers wide and tens to hundreds of micrometers long─representing a novel class of nonequilibrium higher-order self-organization. Here, we report that when phase-separating mixtures of unsaturated lipid, cholesterol, and sphingomyelin are hydrated, the resulting myelins break symmetry and couple their compositional degrees of freedom with the extended myelinic morphology: They produce complementary, interlamellar radial gradients of concentrations of cholesterol (and sphingomyelin) and unsaturated lipid, which stands in stark contrast to interlamellar, lateral phase separation in equilibrated morphologies. Furthermore, the corresponding gradients of molecule-specific chemistries (i.
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- TCF7L2 is a transcription factor that plays a significant role in WNT signaling and is strongly linked to diabetes risk, potentially impacting pancreatic β-cell function via the PI3K/AKT pathway.
- Researchers conducted experiments using MIN6 cells to understand how TCF7L2 affects this pathway, measuring key proteins and insulin secretion.
- The study found that TCF7L2 inhibits the PIK3R1 gene's expression, which activates the PI3K/AKT pathway and boosts insulin release, emphasizing the importance of specific binding motifs for TCF7L2's function.
Article Synopsis
- This study aimed to explore how a specific gene variant, CDKAL1, contributes to the development of diabetic retinopathy (DR) in a Chinese population with type 2 diabetes.
- Researchers conducted a case-control study involving 475 controls and 105 DR patients, genotyping them for the genetic variant rs10946398 using iPLEX technology.
- The results showed that the C allele frequency of rs10946398 was significantly different between the control and DR groups, indicating that this genetic variant is linked to an increased risk of developing DR in patients with diabetes.
Background: Genome-wide association studies (GWAS) have reported that the polymorphism rs5219 of the potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) is associated with type 2 diabetes mellitus (T2DM). Given that diabetic retinopathy (DR) is one of the most common microvascular complications of T2DM, GWAS have identified a number of potential susceptibility genes for DR. However, only a fraction of them have been replicated in different studies and show consistent genetic associations with the occurrence of DR.
View Article and Find Full Text PDFBackground: Peroxisome proliferator-activated receptor gamma coactivator-1α (PPARGC1A/ PGC-1α) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. The activity of PGC-1α or genetic variations in the gene encoding the enzyme may contribute to individual variations in mitochondrial function and insulin resistance or diabetes. The objective of this study was to assess the extent to which PPARGC1A (rs8192678) and serum uric acid (UA) and its interaction impact on T2DM susceptibility in Chinese Han population.
View Article and Find Full Text PDFBackground: The objective of this study was to systematically evaluate the contribution of the insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) to type 2 diabetes mellitus (T2DM) and its interaction with obesity to T2DM susceptibility.
Methods: To clarify whether IGF2BP2 is an independent risk factor for T2DM in Chinese population, we conducted a study with a total of 2,301 Chinese Han subjects, including 1,166 T2DM patients and 1,135 controls, for the genotype of a most common and widely studied polymorphism-rs4402960 of IGF2BP2. Genotyping was performed by iPLEX technology.
[An epidemiological study on diabetic retinopathy among type 2 diabetic patients in Shanghai].
Zhonghua Liu Xing Bing Xue Za Zhi
September 2007
Objective: To investigate the prevalence and risk factors of diabetic retinopathy (DR) among type 2 diabetic patients aged over 30 in Shanghai central area.
Methods: 1039 patients diagnosed with type 2 diabetes mellitus (DM) aged over 30 were investigated by randomized cluster sampling in Shanghai central area and data from 767 of those patients were analyzed.
Results: (1) Among all of the 1534 digital ocular fundus images from 767 patients, 87.