Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by pain, inflammation, and discomfort in the synovial joints. It is critical to understand the pathological mechanisms of RA progression. MicroRNA-378 (miR-378) is highly expressed in the synovium of RA patients and positively correlated with disease severity, but its function and underlying mechanisms remain poorly understood.
View Article and Find Full Text PDFIntroduction: Inducing natural resistance against pathogen infection in postharvest tomatoes is a sustainable strategy for reducing postharvest losses. The action model underlying the resistance enhancement of tomatoes induced by bacterial volatile organic compounds (VOCs) against , however, have not been explored.
Methods: In this study, RNA-seq, metabolomics and physiological analysis were used to evaluate global change of defense response induced by VOCs in tomatoes.
Ultrason Sonochem
November 2024
Rationale: The global burden of sepsis is concentrated in sub-Saharan Africa, where inciting pathogens are diverse and HIV co-infection is a major driver of poor outcomes. Biological heterogeneity inherent to sepsis in this setting is poorly defined.
Objectives: To identify dominant pathobiological signatures of sepsis in sub-Saharan Africa and their relationship to clinical phenotypes, patient outcomes, and biological classifications of sepsis identified in high-income-countries (HICs).
Objective: Distraction osteogenesis (DO) has been widely used to treat bone defects as its effectiveness in bone regeneration. Currently, distraction devices for establishing DO models are mainly developed for rats or large animals. However, a mouse DO model is in great need for in-depth mechanistic investigations using various transgenic mice.
View Article and Find Full Text PDFDiquat (DQ) is a widely utilized nonselective herbicide that is primarily used to control a wide range of weeds and crop residues. It also has significant environmental implications. DQ exposure can cause severe damage to the central nervous system (CNS), a critical symptom of acute poisoning that endangers patients.
View Article and Find Full Text PDFTyphoons greatly affect ocean hydrodynamics, thereby altering ocean productivity and biogeochemistry. This study used stable isotopes and geochemical indicators of particulate organic matter (POM) to investigate the impact of Typhoon Talim (2023) on marine productivity and POM dynamics in Zhanjiang Bay. During the typhoon, an ocean front formed in the upper bay, resulting in a nearly twofold increased POM and enhanced decomposition of resuspended POM, due to the strengthened vertical mixing.
View Article and Find Full Text PDFAncient murals embody profound historical, cultural, scientific, and artistic values, yet many are afflicted with challenges such as pigment shedding or missing parts. While deep learning-based completion techniques have yielded remarkable results in restoring natural images, their application to damaged murals has been unsatisfactory due to data shifts and limited modeling efficacy. This paper proposes a novel progressive reasoning network designed specifically for mural image completion, inspired by the mural painting process.
View Article and Find Full Text PDFRecently, the transportation sector in China has gradually become the main source of urban air pollution and primary driver of carbon emissions growth. Considering air pollutants and greenhouse gases come from the same emission sources, it is necessary to establish an updated high-resolution emission inventory for the transportation sector in Central China, the most polluted region in China. The inventory includes on-road mobile, non-road mobile, oil storage and transportation, and covers 9 types of air pollutants and 3 types of greenhouse gases.
View Article and Find Full Text PDFJ Tradit Complement Med
September 2024
Background And Aim: Muscular atrophy is one of the most common age-related conditions characterized by the deterioration of skeletal muscle structures and impaired functions. It is associated with cellular senescence and chronic inflammation, which impair the function of muscle stem cells. Bazi Bushen (BZBS) is a patent compound Chinese medicine that has been shown to have anti-aging effects in various animal models.
View Article and Find Full Text PDFCell Rep Methods
September 2024
Gene-switch techniques hold promising applications in contemporary genetics research, particularly in disease treatment and genetic engineering. Here, we developed a compact drug-induced splicing system that maintains low background using a human ubiquitin C (hUBC) promoter and optimized drug (LMI070) binding sequences based on the Xon switch system. To ensure precise subcellular localization of the protein of interest (POI), we inserted a 2A self-cleaving peptide between the extra N-terminal peptide and POI.
View Article and Find Full Text PDFLaccase is a green catalyst that can efficiently catalyze phenolic pollutants, and its catalytic efficiency is closely related to the interaction between enzyme and substrates. To investigate the binding effects between enzyme and phenolic pollutants, phenol, p-chlorophenol, and bisphenol A were used as substrates in this study. We focused on the removal and catalytic mechanism of these pollutants in water using yellow laccase derived from Coriolopsis gallica.
View Article and Find Full Text PDFAs a common cardiovascular disease (CVD), Arrhythmia refers to any abnormality in the origin, frequency, rhythm, conduction velocity, timing, pathway, sequence, or other aspect of cardiac impulses, and it is one of the common cardiovascular diseases in clinical practice. At present, various ion channel blockers are used for treatment of arrhythmia that include Na ion channel blockers, K ion channel blockers and Ca ion channel blockers. While these drugs offer benefits, they have led to a gradual increase in drug-related adverse reactions across various systems.
View Article and Find Full Text PDFStem Cell Res
December 2024
Current methodologies for hepatocyte induction from human induced pluripotent stem cells (hiPSCs) have limited efficacy due to lack of a functional hepatocyte reporter. To address this, we developed an endogenous albumin (ALB)-sfGFP reporter system in hiPSCs using homologous directed recombination (HDR)-mediated knock-in. The hiPSCs maintained the characteristic morphology, pluripotency, and normal karyotype while demonstrating successful differentiation into all three germ layers both in vitro and in vivo.
View Article and Find Full Text PDFOsteoporotic bone defects pose a significant challenge for bone regeneration as they exhibit impaired healing capacity and delayed healing period. To address this issue, this study introduces a hydrogel that creates a rejuvenating microenvironment, thereby facilitating efficient bone repair during the initial two weeks following bone defect surgery. The hydrogel, named GelHFS, was created through host-guest polymerization of gelatin and acrylated β-cyclodextrin.
View Article and Find Full Text PDFImproving the accuracy of anthropogenic volatile organic compounds (VOCs) emission inventory is crucial for reducing atmospheric pollution and formulating control policy of air pollution. In this study, an anthropogenic speciated VOCs emission inventory was established for Central China represented by Henan Province at a 3 km × 3 km spatial resolution based on the emission factor method. The 2019 VOCs emission in Henan Province was 1003.
View Article and Find Full Text PDFCysteine palmitoylation or -palmitoylation catalyzed by the ZDHHC family of acyltransferases regulates the biological function of numerous mammalian proteins as well as viral proteins. However, understanding of the role of -palmitoylation in antiviral immunity against RNA viruses remains very limited. The adaptor protein MAVS forms functionally essential prion-like aggregates upon activation by viral RNA-sensing RIG-I-like receptors.
View Article and Find Full Text PDFCardiovascular diseases (CVDs) are one of the most significant diseases that pose a threat to human health. The innovative traditional Chinese medicine Tongxinluo Capsule, developed under the guidance of the theory of traditional Chinese medicine, has good clinical efficacy in various cardiovascular diseases, this medicine has effects such as blood protection, vascular protection, myocardial protection, stabilizing vulnerable plaques, and vasodilation. However, CVDs are a multifactorial disease, and their underlying mechanisms are not fully understood.
View Article and Find Full Text PDF3,5-Dimethyl-8-methoxy-3,4-dihydro-1-isochromen-6-ol (DMD) is a polyketide compound obtained from the endophytic fungus sp. HJT-A-10 of . is a nourishing food and also used in traditional Chinese medicine and Xizang medicine.
View Article and Find Full Text PDFJ Environ Sci (China)
January 2025
This study used steel slag, fly ash, and metakaolin as raw materials (SFM materials) to create silica-alumina-based geopolymers that can solidify Hg when activated with sodium-based water glass. The experiments began with a triangular lattice point mixing design experiment, and the results were fitted, analyzed, and predicted. The optimum SFM material mass ratio was found to be 70% steel slag, 25% fly ash, and 5% metakaolin.
View Article and Find Full Text PDFThis study developed an estimation method for the NO budget using N stable isotope labeling techniques, a dual-layer model and a box model, which was used to elucidate the underlying dynamics of NO accumulation in Zhanjiang Bay. The results showed that although the net input of NO during the rainy season was 2.36 times higher than that during the dry season, the overall NO concentration was only 66.
View Article and Find Full Text PDFSpinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by mutations in the survival motor neuron 1 (SMN1) gene. Gene editing technology repairs the conversion of the 6th base T to C in exon 7 of the paralogous SMN2 gene, compensating for the SMN protein expression and promoting the survival and function of motor neurons. However, low editing efficiency and unintended off-target effects limit the application of this technology.
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