Publications by authors named "Xuan Hu"

In aquatic environments, conditioning layers play a crucial role in modulating the adhesion and aggregation of planktonic bacteria, ultimately facilitating biofilm formation and the irreversible onset of biofouling. This study reports the construction of a simplified conditioning layer using extracellular polymeric substances (EPS) secreted by and its influence on the adherence behaviors of bacteria. The results reveal that the EPS conditioning layer remarkably inhibits the adherence yet promotes the aggregation of .

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Biological control is considered one of the most important methods for preventing and controlling the worldwide fungal disease gray mold, caused by . Among the various agents used in biological control, actinomycetes represent a significant group of microorganisms that offer valuable resources for biocontrol strategies. In this study, a total of 132 actinomycetes, belonging to four genera (, , , and ), were isolated from soil.

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Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses to the swine industry worldwide. Despite numerous studies on this virus, the molecular mechanisms underlying PRRSV infection remain unclear. Enhancer of mRNA decapping 3 (EDC3) is a crucial scaffold protein for P-body assembly that stimulates mRNA decapping by alleviating self-inhibition of the DCP1/2 decapping complex.

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Aldosterone-producing adenoma (APA) is a leading cause of primary aldosteronism (PA), a condition marked by excessive aldosterone secretion. CYP11B2, the aldosterone synthase, plays a critical role in aldosterone biosynthesis and the development of APA. Despite its significance, encoding regulatory mechanisms governing CYP11B2, particularly its degradation, remain poorly understood.

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Article Synopsis
  • This study investigates the long-term effects of non-biodegradable polyethylene terephthalate (PET) and biodegradable polylactic acid (PLA) microplastics on sewage treatment bioreactors, focusing on nitrogen removal performance.
  • The research found that PLA significantly reduced nitrogen removal efficiencies and negatively impacted crucial microbial activities and health, unlike PET, which had less of a detrimental effect.
  • The results highlight the potential risks associated with biodegradable microplastics like PLA in wastewater treatment, suggesting that their impact should be further considered and addressed.
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Object: To clarify the clinical efficacy of washed microbiota transplantation (WMT) for metabolic syndrome (MetS), and explore the differences in the metabolic profile of bacterial outer membrane vesicles (OMVs) in donor fecal bacteria suspension received by MetS patients with good and poor outcomes, and to construct a predictive model for the efficacy of WMT for MetS using differential metabolites.

Methods: Medical data 65 MetS patients who had completed at least 2 courses of WMT from 2017.05 to 2023.

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The pH of environmental systems plays a crucial role in determining pollutant behavior, necessitating the development of effective tools for real-time monitoring. This study introduces a novel series of lipophilic HPTS derivatives, developed through a two-step synthesis route, designed as pH-sensitive dyes, characterized by high fluorescence intensity, photostability, dual excitation/single emission, and significant Stokes shifts. We engineered self-ratiometric pH-sensing planar optode foils and investigated the impact of carbon chain length on foil durability.

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Ethnopharmacological Relevance: Chronic sleep deprivation (CSD) can result in neuronal damage, synaptic dysfunction, Aβ production, neuroinflammation, and ultimately cognitive deterioration. WuYou Decoction (WYD), a contemporary prescription, has shown promise in enhancing sleep quality and cognitive performance in individuals with insomnia. However, the specific molecular mechanisms responsible for the neuroprotective effects of WYD on CSD remain incompletely understood.

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Article Synopsis
  • Stress urinary incontinence (SUI) is a prevalent issue affecting women's quality of life after radical hysterectomy for cervical cancer, with a 27.8% incidence found in a recent study.
  • The study analyzed demographic and clinical data from 97 women, identifying menopause, chronic constipation, and certain urodynamic parameters as significant factors linked to the occurrence of SUI.
  • Key findings suggested that menopausal status and chronic constipation were particularly strong predictors of SUI, highlighting the need for targeted follow-up care for affected patients.
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Ischemic stroke (IS) is a major cause of mortality and morbidity worldwide. Beyond thrombolysis, strategies targeting anti-oxidative apoptosis and angiogenesis are considered prospective therapeutic strategies. Nevertheless, existing natural and clinical remedies have limited efficacy in the management of IS.

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The antibiotic ciprofloxacin (CIP), detected in various aqueous environments, has broad-spectrum antimicrobial properties that can severely affect methanogenic performance in anaerobic systems. In this study, a novel strategy to alleviate the inhibition of AD performance under CIP press with the direct addition of biochar (BC) prepared from corn stover was proposed and the corresponding alleviation mechanism was investigated. When the dosage of BC was 5 and 20 g/L, the cumulative methane production in AD could reach 317.

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Developing nanozyme-based free radical scavenging is a promising signal modulation approach for ECL sensing. Nevertheless, the relatively low antioxidant activity and inherent pro-oxidant activity of numerous nanozymes have significantly hindered the development of this strategy. Here a biofunctional copper-based metal-organic framework (CuMOF) with multiple enzyme-mimicking activities was employed for the modulation of the ECL immunosensor, guided by the self-cascade antioxidant reaction.

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Clear cell renal cell carcinoma (ccRCC) is a malignant tumor needs more effective treatments. TATA box-binding protein-associated factor RNA polymerase I subunit D (TAF1D) is a member of the selective factor 1 complex and functions in RNA polymerase I-dependent transcription. Higher TAF1D expression was found in ccRCC tumor tissues and indicated worse survival.

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As a commonly used medicinal plant, the flavonoid metabolites of Blumea balsamifera and their association with genes are still elusive. In this study, the total flavonoid content (TFC), flavonoid metabolites and biosynthetic gene expression patterns of B. balsamifera after application of exogenous methyl jasmonate (MeJA) were scrutinized.

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Importance: Previous evidence suggests that maternal hepatitis B virus (HBV) infection during prepregnancy or pregnancy is associated with congenital heart diseases (CHDs) in offspring. However, the association of paternal HBV infection with CHDs is not well examined.

Objective: To explore the association of paternal preconception HBV infection with CHDs in offspring.

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The Alpinia oxyphylla fruit (AOF) is a popular condiment and traditional Chinese medicine in Asia, known for its neuroprotective compound nootkatone. However, there has not been a comprehensive study of its flavor or the relationship between sensory and bioactive compounds. To address this issue, we examined AOF's microstructure, flavor, and metabolomic profiles during fruit maturation.

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Ethnopharmacological Relevance: Blumea balsamifera (L.) DC. (BB), the source of Blumea balsamifera oil (BBO), is an aromatic medicinal plant, renowned for its pharmacological properties and its traditional use in Southeast Asian countries such as China, Thailand, Vietnam, Malaysia, and the Philippines for centuries.

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Importance: Many studies have reported that the interpregnancy interval (IPI) is a potential modifiable risk factor for adverse perinatal outcomes. However, the association between IPI after live birth and subsequent spontaneous abortion (SA) is unclear.

Objective: To investigate the association of IPI after a healthy live birth and subsequent SA.

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As a representative gas of food spoilage, the development of rapid hydrogen sulfide (HS) analysis strategies for food safety control is in great demand. Despite traditional methods for HS detection possessing great achievements, they are still incapable of meeting the requirement of portability and quantitative detection at the same time. Herein, a nanozyme catalysis pressure-powered sensing platform that enables visual quantification with the naked eye is proposed.

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A novel co-bonded octyl and pyridine silica (OPS) sorbent was prepared and applied for the solid phase extraction (SPE) of cyclopiazonic acid (CPA, a type of mycotoxin) in feed and agricultural products for the first time. A simple mixed-ligand one-pot reaction strategy was employed for OPS sorbent preparation. Nitrogen adsorption-desorption measurements, elemental analysis (EI), thermal gravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FT-IR) analysis demonstrated the successful immobilization of octyl and quaternary ammonium groups onto the surface of silica gel.

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Background: Early intervention and diagnosis of Metabolic Syndrome (MetS) are crucial for preventing adult cardiovascular disease. However, the optimal indicator for identifying MetS in adolescent remains controversial.

Methods: In total,1408 Chinese adolescents and 3550 American adolescents aged 12-17 years were included.

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What Is Already Known About This Topic?: The significance of maternal liver health concerning preterm birth (PTB) is well recognized; however, there is a gap in understanding the precise influence of preconception serum alanine aminotransferase (ALT) levels on the risk of PTB.

What Is Added By This Report?: In this retrospective cohort study, a J-shaped relationship between preconception serum ALT levels and risk of PTB was observed, indicating that both significantly elevated and decreased ALT levels may contribute to the risk.

What Are The Implications For Public Health Practice?: Maintaining optimal preconception serum ALT levels may reduce the risk of PTB, thereby informing specific preventive measures for women of reproductive age.

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Aluminum (Al) toxicity is the major constraint on plant growth and productivity in acidic soils. An adaptive mechanism to enhance Al tolerance in plants is mediated malate exudation from roots through the involvement of ALMT (Al-activated malate transporter) channels. The underlying Al tolerance mechanisms of stylo (Stylosanthes guianensis), an important tropical legume that exhibits superior Al tolerance, remain largely unknown, and knowledge of the potential contribution of ALMT genes to Al detoxification in stylo is limited.

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In a previous study, we separated an active fucoidan (JHCF4) from acid-processed Sargassum fusiforme, then analyzed and confirmed its structure. In the present study, we investigated the potential anti-inflammatory properties of JHCF4 and a JHCF4-based hydrogel in vitro and in vivo. JHCF4 reliably inhibited nitric oxide (NO) production in LPS-induced RAW 264.

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Multi-image steganography, a technique for concealing information within multiple carrier mediums, finds remote sensing images to be particularly apt carriers due to their complex structures and abundant texture data. These characteristics bolster the resilience against steganalysis and enhance steganographic capacity. The efficacy of multi-image steganography hinges on the diplomatic strategy of cover selection and the meticulous allocation of the payload.

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