Publications by authors named "Xuan Gong"

Investigate the impact of diaphragm sellae competence on surgical outcomes and risk factors for postoperative hypothalamic injury (HI) in patients undergoing endoscopic transsphenoidal surgery (ETS) for infradiaphragmatic craniopharyngiomas (ICs). A retrospective analysis of 54 consecutive patients (2016-2023) with ICs treated by ETS was conducted. All tumors originated from the sellar region inferior to the diaphragm sellae and were classified into two subtypes in terms of diaphragm sellae competence: IC with competent diaphragm sellae (IC-CDS) and IC with incompetent diaphragm sellae (IC-IDS).

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Article Synopsis
  • This study investigates the link between enlarged perivascular spaces (EPVSs) observed in MRI scans and cognitive impairment shortly after an acute ischemic stroke (AIS) in a Chinese population, aiming to provide early indicators for clinicians.
  • Researchers analyzed clinical data from 208 patients using cognitive assessment tests (MoCA-BJ and MMSE) and found that factors like age, education, and the severity of EPVSs in specific brain areas correlated with increased cognitive impairment in AIS patients.
  • While EPVS severity and location are associated with cognitive issues such as attention and orientation, multivariate analysis did not classify EPVSs as a primary risk factor for early cognitive impairment after an AIS.
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The global demand for dialysis among patients with end-stage kidney disease has surpassed the capacity of public healthcare, a trend that has intensified. While wearable artificial kidney (WAK) technology is seen as a crucial solution to address this demand, there is an urgent need for both efficient and renewable toxin-adsorbent materials to overcome the long-standing technological challenges in terms of cost, device size, and sustainability. In this study, we employed screening experiments for adsorbent materials, multimodal characterization, and Monte Carlo adsorption simulations to identify a synthetic self-assembly silicalite-1 zeolite that exhibits highly ordered crystal arrays along the [010] face (-axis) direction, demonstrating exceptional adsorption capabilities for small molecular toxins such as creatinine and urea associated with uremia.

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Understanding the mechanistic intricacies of hydrothermally treated zeolite is crucial for valorizing any oxygen-containing renewable feedstocks (e. g., methanol, carbon dioxide, biomass).

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Diffuse gliomas in adults are highly infiltrative and largely incurable. Whole exome sequencing (WES) has been demonstrated very useful in genetic analysis. Here WES was performed to characterize genomic landscape of adult-type diffuse gliomas to discover the diagnostic, therapeutic and prognostic biomarkers.

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The zeolite-catalyzed methanol-to-aromatics (MTA) process is a promising avenue for industrial decarbonization. This process predominantly utilizes 3-dimensional 10-member ring (10-MR) zeolites like ZSM-5 and ZSM-11, chosen for their confinement effect essential for aromatization. Current research mainly focuses on enhancing selectivity and mitigating catalyst deactivation by modulating zeolites' physicochemical properties.

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In the context of advancing social modernization, the projected shortfall in the demand for renewable aromatic hydrocarbons is expected to widen, influenced by industries like high-end materials, pharmaceuticals, and consumer goods. Sustainable methods for aromatic production from alternative sources, particularly the methanol-to-aromatics (MTA) process using zeolite ZSM-5 and associated with the "methanol economy", have garnered widespread attention. To facilitate this transition, our project consolidates conventional strategies that impact aromatics selectivity-such as using hierarchical zeolites, metallic promoters, or altering zeolite physicochemical properties-into a unified study.

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This project addresses the urgent need for efficient and cost-effective development of electrocatalysts for the ethanol oxidation reaction (EOR). This reaction offers promising renewable energy solutions but faces challenges due to the slow EOR kinetics, typically requiring costly noble metal catalysts. To overcome these limitations, this study focuses on developing CuZn-based EOR catalysts derived from metal-organic frameworks (MOFs), focusing on understanding the structure-performance relationship between pristine MOF-based electrocatalysts and their pyrolyzed counterparts.

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The evolution and utilization of limbs facilitated terrestrial vertebrate movement on land, but little is known about how other lateral structures enhance terrestrial locomotion in amphibian fishes without terrestrialized limb structures. Climbing perch (Anabas testudineus) exhibit sustained terrestrial locomotion using uniaxial rotating gill covers instead of appendages. To investigate the role of such simple lateral structures in terrestrial locomotion and the motion-generating mechanism of the corresponding locomotor structure configuration (gill covers and body undulation), we measured the terrestrial kinematics of climbing perch and quantitatively analysed its motion characteristics.

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Background: Besides the hallmark of H3K27M mutation, aberrant amplifications of receptor tyrosine kinases (RTKs) are commonly observed in diffuse midline glioma (DMG), a highly malignant brain tumor with dismal prognosis. Here, we intended to evaluate the efficacy and safety of a multitarget RTK inhibitor anlotinib in patients with H3K27M-DMG.

Methods: A total of 40 newly diagnosed H3K27M-DMG patients including 15 with anlotinib and 25 without anlotinib treatment were retrospectively enrolled in this cohort.

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Article Synopsis
  • - A methanol-based economy aims to tackle energy transition challenges by utilizing a zeolite-catalyzed methanol-to-hydrocarbons (MTH) process to create synthetic fuels and chemicals from renewable sources
  • - Despite its potential, the MTH process has faced obstacles, mainly due to its complex mechanisms that hinder widespread use, particularly in CO-neutral systems
  • - This study bridges knowledge gaps by exploring MTH mechanisms through various advanced techniques, revealing how (Koch-)carbonyl groups enhance specific pathways that significantly influence the production of valuable compounds like benzene, toluene, and xylene (BTX)!
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The selective hydrogenation of aldehydes and olefins plays a crucial role in the synthesis of various industrial products. Immobilizing noble metal catalysts on solid supports has been pursued to overcome the challenges associated with catalyst separation and recovery. In this study, we explore the use of metal-organic frameworks (MOFs) as supports for the immobilization of molecular ruthenium catalysts in the hydrogenation of olefins and aldehydes.

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ConspectusThirty years ago, George A. Olah proposed the concept of the methanol economy, where methanol replaces fossil fuels as a means of energy storage, ground transportation fuel, and raw material for the manufacture of other carbon-based products. Over the years, with rising global warming concerns, the concept has evolved.

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Blood vessels are essential for nutrient and oxygen delivery and waste removal. Scaffold-repairing materials with functional vascular networks are widely used in bone tissue engineering. Additive manufacturing is a manufacturing technology that creates three-dimensional solids by stacking substances layer by layer, mainly including but not limited to 3D printing, but also 4D printing, 5D printing and 6D printing.

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Mono(ADP-ribosyl)ation (MARylation) is emerging as a critical regulator of ribosome function and translation. Herein, we demonstrate that RACK1, an integral component of the ribosome, is MARylated on three acidic residues by the mono(ADP-ribosyl) transferase (MART) PARP14 in ovarian cancer cells. MARylation of RACK1 is required for stress granule formation and promotes the colocalization of RACK1 in stress granules with G3BP1, eIF3η, and 40S ribosomal proteins.

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The CO -to-aromatics process is a chemical reaction that converts carbon dioxide (CO ) into valuable petrochemical, i. e., aromatics (especially, benzene, toluene, and xylene) over the metal/zeolite bifunctional catalytic systems.

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Aims: H3K27M-mutant diffuse midline glioma (DMG) is a rare and aggressive central nervous system tumor. The biological behavior, clinicopathological characteristics, and prognostic factors of DMG have not yet been completely uncovered, especially in adult patients. This study aims to investigate the clinicopathological characteristics and identify prognostic factors of H3K27M-mutant DMG in pediatric and adult patients, respectively.

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Simultaneous wireless information and power transfer (SWIPT) technology can effectively extend the lifecycle of energy-constrained networks. In order to improve the energy harvesting (EH) efficiency and network performance in secure SWIPT networks, this paper studies the resource allocation problem based on the quantitative EH mechanism in the secure SWIPT network. Based on a quantitative EH mechanism and nonlinear EH model, a quantified power-splitting (QPS) receiver architecture is designed.

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Synopsis of recent research by authors named "Xuan Gong"

  • - Xuan Gong's research spans multiple disciplines, including neuroscience, materials science, and biology, focusing on cognitive impairment following acute ischemic stroke, innovative dialysis solutions, and the locomotion patterns of climbing perch.
  • - Recent findings indicate a potential link between enlarged perivascular spaces and cognitive impairment after ischemic stroke, and a novel zeolite compound exhibits high adsorption efficiency for toxins related to kidney function, proposing new avenues for wearable artificial kidney technologies.
  • - In addition, the research highlights advancements in zeolite catalysis, specifically in the methanol-to-aromatics process, and explores the locomotion mechanics of climbing perch, contributing valuable insights to both industrial applications and biological understanding.