Mediation Analysis of Gut Microbiota and Plasma Metabolites in Asthma Pathogenesis Using Mendelian Randomization.

Asthma is a prevalent chronic respiratory condition with multifactorial pathogenesis. Emerging evidence suggests that gut microbiota and their metabolites influence asthma risk. This study explores the mediation effects of plasma metabolites between gut microbiota and asthma using Mendelian randomization (MR) analysis.

The role of gut microbiota and plasma metabolites in ulcerative colitis: Insights from Mendelian randomization analysis.

Emerging research suggests that alterations in gut microbiota composition may play a significant role in the pathogenesis of ulcerative colitis (UC). Plasma metabolites, which are influenced by gut microbiota, have also been implicated, but their role in UC remains unclear. This study aims to determine whether specific plasma metabolites mediate the causal relationship between gut microbiota and UC using Mendelian randomization (MR) analysis.

NSUN3 Aggravates Sepsis-Associated Acute Kidney Injury by Stabilising TIFA mRNA Through m5C.

Background: Acute kidney injury (AKI) is a common complication of sepsis and also a risk factor for progression of chronic kidney disease. NOP2/Sun RNA methyltransferase 3 (NSUN3) is involved in the regulation of sepsis progression. However, the mechanism by which NSUN3 regulates sepsis-associated AKI (SA-AKI) remains unclear.

Microscopic messengers: microbiota-derived bacterial extracellular vesicles in inflammatory bowel disease.

Inflammatory bowel disease (IBD) is a persistent and complex condition accomplished by inflammation of the gastrointestinal system, encompassing Crohn's disease (CD) and ulcerative colitis (UC). This condition is caused by the combination of genetic predispositions, environmental triggers, and dysregulated immunological responses, which complicates diagnosis and treatment. The latest developments in gastroenterology have revealed the critical significance of the gut microbiota in the pathogenesis of IBD.

Severe Traumatic Brain Injury Outcomes in Patients with Premorbid Psychiatric Illness.

Objective: Individuals with psychiatric illnesses (PIs) have increased rates of traumatic brain injury (TBI). Nonetheless, the influence of underlying PI on TBI outcomes is poorly understood.

Methods: We analyzed the medical records of 633 adult-severe TBI patients admitted to our institution between 2010 and 2021.

Hemostatic Interventions and All-Cause Mortality in Hemodynamically Unstable Pelvic Fractures: A Systematic Review and Meta-Analysis.

Objective: To conduct a systematic review and meta-analysis of the all-cause mortality associated with the most commonly used hemostatic treatments in patients with hemodynamically unstable pelvic fractures.

Methods: Up to April 30, 2023, we searched PubMed, Embase, Web of Science, and Cochrane, including the references to qualified papers. A meta-analysis was performed on studies that reported odds ratios (ORs) or the number of events needed to calculate them.

Genetic associations between gut microbiota and type 2 diabetes mediated by plasma metabolites: a Mendelian randomization study.

Background: Numerous research studies have indicated a possible association between type 2 diabetes (T2DM) and gut microbiota. To explore specific metabolic pathways connecting gut microbiota and T2DM, we employed Mendelian randomization (MR) and linkage disequilibrium score regression (LDSC) techniques.

Methods: This research utilized data from genome-wide association studies (GWAS) that are publicly accessible.

Smoking behaviors, physical activities, pulmonary diseases and COVID-19 severity: A Mendelian randomization study.

Smoking behaviors, physical activities, and pulmonary diseases have been revealed to be associated with COVID-19 severity through observational research. The possible causative effect remains undetermined. To investigate this, we thus carried out a Mendelian randomization (MR) analysis.

Genetic associations between gut microbiota and allergic rhinitis: an LDSC and MR analysis.

Background: Several studies have suggested a potential link between allergic rhinitis (AR) and gut microbiota. In response, we conducted a meta-analysis of Linkage Disequilibrium Score Regression (LDSC) and Mendelian randomization (MR) to detect their genetic associations.

Methods: Summary statistics for 211 gut microbiota taxa were gathered from the MiBioGen study, while data for AR were sourced from the Pan-UKB, the FinnGen, and the Genetic Epidemiology Research on Aging (GERA).

Central Retinal Artery Occlusion: Visual Outcomes from a Large Northern California Cohort.

Purpose: To assess visual acuity (VA) outcomes in a large cohort of patients diagnosed with nonarteritic central retinal artery occlusion (CRAO), and to ascertain whether time from symptom onset to presentation, presenting VA, or conservative treatment delivery (anterior chamber paracentesis, ocular massage, intraocular pressure lowering drugs, hyperventilation, or some combination of those) impacted ultimate VA outcomes.

Design: Retrospective cohort study.

Subjects: The study included 794 patients who presented with CRAO between 2011 and 2020.

In-Hospital Amantadine Does Not Improve Outcomes After Severe Traumatic Brain Injury: An 11-Year Propensity-Matched Retrospective Analysis.

Background: Disruption of dopamine neurotransmission is associated with functional impairment after severe traumatic brain injury (sTBI). This has prompted the study of dopamine agonists, such as amantadine, to assist recovery of consciousness. Randomized trials have mostly addressed the posthospital setting, with inconsistent findings.

Predicting traumatic brain injury outcomes using a posterior dominant rhythm.

Objective: Predicting severe traumatic brain injury (sTBI) outcomes is challenging, and existing models have limited applicability to individual patients. This study aimed to identify metrics that could predict recovery following sTBI. The researchers strived to demonstrate that a posterior dominant rhythm on electroencephalography is strongly associated with positive outcomes and to develop a novel machine learning-based model that accurately forecasts the return of consciousness.

Efficient removal and recovery of phosphorus from industrial wastewater in the form of vivianite.

With the shortage of phosphorus resources, the concept of phosphorus recovery from wastewater is generally proposed. Recently, phosphorus recovery from wastewater in the form of vivianite has been widely reported, which could be used as a slow-release fertilizer as well as the production of lithium iron phosphate for Li-ion batteries. In this study, chemical precipitation thermodynamic modeling was applied to evaluate the effect of solution factors on vivianite crystallization with actual phosphorus containing industrial wastewater.

[Promoting Nitrogen Removal in ANAMMOX Biofilm Reactor by Fe Under Low Nitrogen Concentration].

The feasibility for nitrogen removal in a two-stage ANAMMOX biofilm reactor promoted by Fe under low nitrogen concentration was investigated. The results showed that the ANAMMOX reaction could be effectively promoted by a (Fe) of 5, 10, and 15 mg·L. A (Fe) of 10 mg·L presented the highest promotion for the ANAMMOX reaction, with the highest nitrogen removal efficiency (NRE) of 81.

Advanced treatment of phosphorus-containing tail water by Fe-Mg-Zr layered double hydroxide beads: Performance and mechanism.

The adsorption process for low concentration phosphorus wastewater treatment has advantages of simple convenience, stable performance and less sludge, while most of current adsorbents fail to be separated for reuse. Meanwhile, few people pay attention to the removal of low concentration phosphorus from tail water by adsorbents. In this study, a newly efficient Fe-Mg-Zr layered double hydroxide beads were prepared by simple in-situ crosslinking method and applied for low concentration phosphorus adsorption from real tail water.

Highly multiplexed oligonucleotide probe-ligation testing enables efficient extraction-free SARS-CoV-2 detection and viral genotyping.

There is an urgent and unprecedented need for sensitive and high-throughput molecular diagnostic tests to combat the SARS-CoV-2 pandemic. Here we present a generalized version of the RNA-mediated oligonucleotide Annealing Selection and Ligation with next generation DNA sequencing (RASL-seq) assay, called "capture RASL-seq" (cRASL-seq), which enables highly sensitive (down to ~1-100 pfu/ml or cfu/ml) and highly multiplexed (up to ~10,000 target sequences) detection of pathogens. Importantly, cRASL-seq analysis of COVID-19 patient nasopharyngeal (NP) swab specimens does not involve nucleic acid purification or reverse transcription, steps that have introduced supply bottlenecks into standard assay workflows.

Effect of hydraulic retention time on effluent pH in anammox bioreactors: Characteristics of effluent pH and pH as an indicator of reactor performance.

In order to assess the performance of anaerobic ammonium oxidation (anammox) bioreactors, it is necessary to study the stoichiometry of the anammox reaction and pH. This study focused on the effect of the hydraulic retention time (HRT) on the effluent pH in anammox-upflow anaerobic sludge blanket (UASB) bioreactors. Anammox-UASB bioreactors with and without a recirculation system were used to investigate the effluent pH and bioreactor performance.

Ultra-efficient sequencing of T Cell receptor repertoires reveals shared responses in muscle from patients with Myositis.

Background: Myositis, or idiopathic inflammatory myopathy (IIM), is a group disorders of unknown etiology characterized by the inflammation of skeletal muscle. The role of T cells and their antigenic targets in IIM initiation and progression is poorly understood. T cell receptor (TCR) repertoire sequencing is a powerful approach for characterizing complex T cell responses.

Highly multiplexed oligonucleotide probe-ligation testing enables efficient extraction-free SARS-CoV-2 detection and viral genotyping.

The emergence of SARS-CoV-2 has caused the current COVID-19 pandemic with catastrophic societal impact. Because many individuals shed virus for days before symptom onset, and many show mild or no symptoms, an emergent and unprecedented need exists for development and deployment of sensitive and high throughput molecular diagnostic tests. RNA-mediated oligonucleotide Annealing Selection and Ligation with next generation DNA sequencing (RASL-seq) is a highly multiplexed technology for targeted analysis of polyadenylated mRNA, which incorporates sample barcoding for massively parallel analyses.

Comparative efficacy of the front-line anti-HBV drugs in nucleos(t)ide analogue-naive chronic hepatitis B: A protocol for systematic review and network meta-analysis.

Background:: During the COVID-19 period, there was a huge gap in the understanding of masks between east and west. At the same time, the mechanism of the mask and the effect after use, also appeared differences. The Objective of this Meta-analysis is to systematically evaluate the efficacy of masks for influenza in the community.

Nitrite accumulation stability evaluation for low-strength ammonium wastewater by adsorption and biological desorption of zeolite under different operational temperature.

How to achieve stable nitrite accumulation was still a huge challenge for low-carbon and energy-saving biological nitrogen removal of low-strength ammonium wastewater. This study proposed a new way to solve this problem with zeolite biological fixed bed (ZBFB) by cycle operation of adsorption and biological desorption. In order to evaluate nitritation performance of this reactor, the influence of operational temperature on nitrite accumulation stability was investigated by 126 cycles operation in four parallel ZBFB reactors for low-strength ammonium wastewater (50 mg/L NH-N).