Analyzes of pan-genome and resequencing atlas unveil the genetic basis of jujube domestication.

Jujube (Ziziphus jujuba Mill.), belonging to the Rhamnaceae family, is gaining increasing prominence as a perennial fruit crop with significant economic and medicinal values. Here, we conduct de novo assembly of four reference-grade genomes, encompassing one wild and three cultivated jujube accessions.

Genomes of autotetraploid wild and cultivated Ziziphus mauritiana reveal polyploid evolution and crop domestication.

Indian jujube (Ziziphus mauritiana) holds a prominent position in the global fruit and pharmaceutical markets. Here, we report the assemblies of haplotype-resolved, telomere-to-telomere genomes of autotetraploid wild and cultivated Indian jujube plants using a 2-stage assembly strategy. The generation of these genomes permitted in-depth investigations into the divergence and evolutionary history of this important fruit crop.

From phenotyping to genetic mapping: identifying water-stress adaptations in legume root traits.

Background: Climate change induces perturbation in the global water cycle, profoundly impacting water availability for agriculture and therefore global food security. Water stress encompasses both drought (i.e.

Reinforced GNNs for Multiple Instance Learning.

Multiple instance learning (MIL) trains models from bags of instances, where each bag contains multiple instances, and only bag-level labels are available for supervision. The application of graph neural networks (GNNs) in capturing intrabag topology effectively improves MIL. Existing GNNs usually require filtering low-confidence edges among instances and adapting graph neural architectures to new bag structures.

An efficient constructive heuristic for the rectangular packing problem with rotations.

The rectangular packing problem has been extensively studied over the years due to its wide application in industry. However, most of the research efforts are devoted to positioning techniques of the rectangles for various problem variants, the efficient implementation of the packing procedure is relatively less studied. In this paper, we propose an efficient constructive algorithm for the rectangular packing problem with rotations.

Postoperative fibrinogen-to-albumin ratio acting as an indicator of futile recanalization in patients with successful thrombectomy.

Background: Timely recognition of futile recanalization might enable a prompter response and thus improve outcomes in patients receiving successful thrombectomy. This study aims to evaluate whether postoperative fibrinogen-to-albumin ratio (FAR) could act as an indicator of futile recanalization.

Methods: This is a single-center, retrospective analysis of patients with acute anterior circulation large-vessel occlusion and successful thrombectomy between May 2019 and June 2022.

Potassium stearate doped PEDOT:PSS improves the performance of inverted perovskite solar cells.

Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) suffers from lower conductivity and surface defects, which hinders the extraction and transport of effective charges, thereby reducing the Power conversion efficiency (PCE) and long-term stability of PSCs. Therefore, this study introduces potassium stearate (KSt) doping in PEDOT:PSS to regulate its conductivity and interface charge transfer. As a result, KSt-doped PEDOT:PSS increase the PCE of the device from 16.

Safety and Efficacy of Aspiration Catheter CAT6 and 5 Fr Navien in the Endovascular Treatment of Acute Ischemic Stroke.

Background: Mechanical thrombectomy has become a key treatment option for acute ischemic stroke. This study compared the safety and efficacy of aspiration catheter CAT6 and 5 Fr Navien.

Methods: Thrombectomy was performed in103 patients with the acute internal carotid artery, middle cerebral artery M1 or M2 occlusions, including the CAT6 group (n=53 with stent retriever and CAT6 aspiration) and the 5 Fr Navien group (n=50 with stent retriever and 5 Fr Navien aspiration) at the Advanced Stroke Center.

CircCRIM1/microRNA-141-3p/thioredoxin-binding protein axis mediates neuronal apoptosis after cerebral ischemia-reperfusion.

Numerous studies have indicated enrichment of circular RNA (circRNA) in the brain takes on a momentous role in cerebral ischemia-reperfusion (CIR) injury. A recent study discovered a novel circCRIM1, was highly expressed in the middle cerebral artery occlusion-reperfusion (MCAO/R) model. Nevertheless, its specific biological function remained unknown.

Analysis of Metabolites and Metabolic Pathways of Three Chinese Jujube Cultivar.

Most studies on metabolites in jujube fruits focus on specific types of metabolites, but there are only a few comprehensive reports on the metabolites in jujube fruits. In order to understand the variance of metabolites in fruits of different jujube varieties. The objective of this study was to explore the metabolic components of jujube fruit by comparing three cultivars, namely Linyi LiZao (LZ), Jiaocheng SuantianZao (STZ), and Xianxian Muzao (MZ).

Effects of four disease-controlling agents (chlorothalonil, CuCl, harpin, and melatonin) on postharvest jujube fruit quality.

Postharvest senescence and disease development can reduce the nutritional value of fresh jujube fruit. Herein, four different disease-controlling agents (chlorothalonil, CuCl, harpin and melatonin) were separately applied to fresh jujube fruit, and all improved postharvest quality (evaluated by disease severity, antioxidant accumulation and senescence) relative to controls. Disease severity was drastically inhibited by these agents, in the order chlorothalonil > CuCl > harpin > melatonin.

is involved in the fruit coloration in Mill. by regulating anthocyanin accumulation.

Fruit color is one of the most important traits of jujube ( Mill.). However, the differences in the pigments of different varieties of Jujube are not well studied.

Quantification and identification analysis of Mill. peel pigmentation at different developmental stages.

The fruit peel of a color mutant jujube cultivar, 'Sanbianhong' (SBF), was investigated using an ultra-high performance liquid chromatography quadrupole Orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS) at five ripening stages (S1, Young fruit stage; S2, swelling stage; S3, white-mature stage; S4, pre-mature stage and S5, mature stage). Lutein, β-carotene, chlorophyll , chlorophyll , and 13 anthocyanins were identified. Chlorophyll and cyanidin 3-O-galactoside were considered key color metabolites in S1 with the content of 1.

Malus asiatica as a natural host of apple scar skin viroid in China.

Malus asiatica (Rosaceae, Malus) is a small deciduous tree, which has been cultivated in China more than 450 years (Jin, 2019). M. asiatica is deeply favored by consumers because of its sweet taste and high nutritional attributes, rich in vitamins, minerals and dietary fiber (Xue et al, 2013).

Deep reinforcement learning guided graph neural networks for brain network analysis.

Modern neuroimaging techniques enable us to construct human brains as brain networks or connectomes. Capturing brain networks' structural information and hierarchical patterns is essential for understanding brain functions and disease states. Recently, the promising network representation learning capability of graph neural networks (GNNs) has prompted related methods for brain network analysis to be proposed.

Circular RNA PUM1 performs as a competing endogenous RNA of microRNA-340-5p to mediate DEAD-box helicase 5 to mitigate cerebral ischemia-reperfusion injury.

Cerebral ischemia-reperfusion damages local brain tissue and impairs brain function, but its specific pathogenesis is still uncertain. Recent studies have clarified circPUM1 is aberrantly elevated in cerebral ischemia-reperfusion injury; however, circPUM1's function in cerebral ischemia-reperfusion-induced neuronal injury remains ambiguous. The results illustrated circPUM1 and DEAD-box helicase 5 were decreased, but microRNA-340-5p was elevated in transient middle cerebral artery occlusion mice and oxygen glucose deprivation/reoxygenation-treated SH-SY5Y cells.

Simplified classification of cavernous internal carotid artery tortuosity: a predictor of procedural complexity and clinical outcomes in mechanical thrombectomy.

Objectives: Thromboaspiration catheters are increasingly used for the endovascular treatment of large vessel stroke (LVS), while tortuous vascular anatomy still remains one major challenge in mechanical thrombectomy. Prompt assessing and understanding cavernous internal carotid artery (cICA) tortuosity may help to predict procedural complexities of mechanical thrombectomy and thus improve the clinical outcomes.

Methods: A retrospective review was performed on a cohort of LVS patients with thromboaspiration catheter.

Outcomes After a Single Ovarian Stimulation Cycle in Women of Advanced Reproductive Age: A Retrospective Analysis.

Objectives: Previous studies showed that age is the most important factor that determines the outcome after embryo transfer (ET), with either fertilization (IVF) or intracytoplasmic sperm injection (ICSI), regardless whether fresh or frozen cycles. The average cumulative live birth rate (CLBR) following a single ovarian stimulation cycle in women of advanced reproductive age (≥38 years of age) has been reported to be 22.6-34.

Synthesis of Stable Lead-Free Cs Sb (Br I ) (0 ≤ x ≤ 1) Perovskite Nanoplatelets and Their Application in CO Photocatalytic Reduction.

Exploring photocatalysts to foster CO photoreduction into high value-added chemicals is of great significance. Lead halide perovskites (LHPs) have recently been extensively investigated as photocatalysts, owing to their facile fabrication and prominent optoelectronic properties. However, the toxicity of lead and instability will hinder their future large-scale applications.

Determination of 11 minerals in children using inductively coupled plasma mass spectrometry.

Background: Minerals play an important role in children's growth and cognition. In this study, our aim was to establish reference intervals of mineral level in Children of Liaoning province (China) and provide a reliable basis for future preventive healthcare guidelines.

Methods: Random samples of 2217 healthy children aged 0-15 years who were referred for routine hospital laboratory examinations in the cities of Shenyang, Fushun, Fuxin, Benxi, Chaoyang and Lingyuan were invited to participate in the study.

Interaction Between Chinese Medicine and Warfarin: Clinical and Research Update.

Warfarin is a commonly used oral anticoagulant. It has a narrow therapeutic window and wide variation in individualized dosing, and is used clinically for the treatment of thromboembolic diseases. Due to the widespread use of traditional Chinese medicine (TCM) in China and the complex composition and diverse mechanisms of action of TCM, the combination of TCM and warfarin in patients has led to fluctuations in the international normalized ratio of warfarin or bleeding.

Depleting SOX2 improves ischemic stroke via lncRNA PVT1/microRNA-24-3p/STAT3 axis.

Objectives: Studies have widely explored in the filed of ischemic stroke (IS) with their focus on transcription factors. However, few studies have pivoted on sex determining region Y-box 2 (SOX2) in IS. Thus, this study is launched to figure out the mechanisms of SOX2 in IS.

Impact of Hydroiodic Acid on Resistive Switching Performance of Lead-Free CsCuI Perovskite Memory.

Herein, we employed lead-free CsCuI perovskite films as the functional layers to construct Al/CsCuI/ITO memory devices and systematically investigated the impact on the corresponding resistive switching (RS) performance via adding different amounts of hydroiodic acid (HI) in CsCuI precursor solution. The results demonstrated that the crystallinity and morphology of the CsCuI films can be improved and the resistive switching performance can be modulated by adding an appropriate amount of HI. The obtained CsCuI films by adding 5 μL HI exhibit the fewest lattice defects and flattest surface (RMS = 13.

Metabolic and transcriptomic analyses reveal different metabolite biosynthesis profiles between leaf buds and mature leaves in Ziziphus jujuba mill.

Jujube leaf is well known for its high nutritional value and medicinal benefits. However, a thorough and dynamic assessment of the metabolites present in jujube leaves is lacking. Here, the primary and secondary metabolites from purple leaf buds and green mature leaves were investigated using ultra-high-performance liquid chromatography/tandem mass spectrometry.