Therapeutic potential of farnesoid X receptor agonists for modulating inflammation and periodontal regeneration.

Objectives: Inflammation and osteoclast activity are important in various diseases, including periodontitis and osteoporosis. Farnesoid X receptor (FXR) has been identified as a promising target for modulating these processes. This study delved into the impact of FXR agonists on inflammation and periodontal regeneration using periodontitis models.

HSP90AA1 promotes the inflammation in human gingival fibroblasts induced by Porphyromonas gingivalis lipopolysaccharide via regulating of autophagy.

Background: Peri-implantitis of tooth seriously affects the life quality of patients. This study aimed to investigate the role of HSP90AA1 in the inflammatory of human gingival fibroblasts (HGFs) induced by porphyromonas gingivalis lipopolysaccharide (Pg-LPS), and to provide a potential therapeutic target for clinical treatment of peri-implantitis.

Methods: Pg-LPS (0.

Inhibition of miR-497 Attenuates Oral Submucous Fibrosis by Inhibiting Myofibroblast Transdifferentiation in Buccal Mucosal Fibroblasts.

Purpose: Oral submucous fibrosis (OSF) is a common chronic condition with poor prognosis, and existing therapies for OSF are limited in effectiveness. This study was designed to explore the role of miR-497 in arecoline (AR)-induced OSF.

Materials And Methods: After miR-497 was silenced or overexpressed in buccal mucosa fibroblasts (BMFs), different concentrations of AR (5-200 μg/ml) were applied to incubate BMFs, and 50 μg/ml of AR was chosen for subsequent experiments.

Identification of key genes and pathways for peri-implantitis through the analysis of gene expression data.

The present study attempted to identify potential key genes and pathways of peri-implantitis, and to investigate the possible mechanisms associated with it. An array data of GSE57631 was downloaded, including six samples of peri-implantitis tissue and two samples of normal tissue from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) in the peri-implantitis samples compared with normal ones were analyzed with the limma package.

[Mechanical properties of thermodynamic nickel-titanium archwires in a simulated oral environment in vitro].

Objective: This study was to investigate the mechanical properties of thermodynamic nickel-titanium (NiTi) archwires of different brands under controlled temperature and in artificial saliva to provide some reference for its clinical application.

Methods: Using a modified partial dental arch bending system, four types of thermodynamic NiTi archwires were tested under controlled temperature (25, 33, 37, 60 degrees C) and in artificial saliva. An Instron Universal Testing Machine was used to apply 3 mm deflections of archwires in the lateral incisor area.

[Study of mechanical properties' secular variation of thermodynamic nickel-titanium archwires].

Purpose: To study the changes of mechanical properties of thermodynamic nickel-titanium(NiTi) archwires under 37 degrees centigrade and in artificial saliva.

Methods: Using a modified partial dental arch bending device, 4 types of 0.016-inch in diameter thermodynamic NiTi archwires were tested in 37degrees centigrade artificial saliva and at different moments in 8 weeks.

[Clinical application and design of rotating auxiliary spring for rotated tooth in edgewise technique].

The structural theory and fabrication of a self-designed rotating auxiliary spring in edgewise technique were described. Rotating auxiliary spring was applied to correct rotated tooth in clinic. It indicated that rotating auxiliary spring was an easy-fabricated, convenient-manipulated device, and could produce an effective treatment results in correcting rotated tooth, especially in the final adjustment stage.