Role of tendon-derived stem cells in tendon and ligament repair: focus on tissue engineer.

This review offered a comprehensive analysis of tendon and ligament injuries, emphasizing the crucial role of tendon-derived stem cells (TDSCs) in tissue engineering as a potential solution for these challenging medical conditions. Tendon and ligament injuries, prevalent among athletes, the elderly, and laborers, often result in long-term disability and reduced quality of life due to the poor intrinsic healing capacity of these avascular structures. The formation of biomechanically inferior scar tissue and a high rate of reinjury underscore the need for innovative approaches to enhance and guide the regenerative process.

Selective STAT3 inhibitor STX-0119 alleviates osteoarthritis progression by modulating the STAT3/PPARγ signaling pathway.

Osteoarthritis (OA), characterized by chronic pain, significantly affects the quality of life of affected individuals. Key factors in OA pathogenesis include cartilage degradation and inflammation. Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, plays a pivotal role in mediating inflammation.

Global research trends and hotspots on tendon-derived stem cell: a bibliometric visualization study.

This study was aimed to examine the global research status and current research hotspots in the field of tendon stem cells. Bibliometric methods were employed to retrieve relevant data from the Web of Science Core Collection (WOSCC) database. Additionally, Citespace, Vosviewer, SCImago, and Graphad Prism were utilized to analyze the publication status in this field, identify the current research hotspots, and present a mini-review.

Identification of PRTN3 as a novel biomarker for the diagnosis of early gastric cance.

Gastric cancer (GC) remains one of the most common types of cancer worldwide and has a high mortality rate. However, tools for the early detection of gastric cancer are still lacking. Isobaric tagging for relative and absolute quantitation (iTRAQ) proteomic assays were conducted to identify and quantify the differentially expressed proteins (DEPs) in the gastric mucosal tissues of GC patients at different stages.

Curcumin activates autophagy and attenuates high glucose-induced apoptosis in HUVECs through the ROS/NF-κB signaling pathway.

Curcumin (CUR) is well known for its anti-inflammatory and antioxidant effects. However, the endothelial protective effect of CUR in diabetes and the underlying signaling pathway remains unclear. The goal of the current study was to provide evidence regarding the protective mechanism of CUR against the high glucose (HG)-induced damage to human umbilical vein endothelial cells (HUVECs).

Carvacrol Suppresses Human Osteosarcoma Cells via the Wnt/β-Catenin Signaling Pathway.

Background: Carvacrol is a monoterpenic phenol extracted from traditional Chinese herbs, including oregano and thyme. Currently, carvacrol has been widely studied for its therapeutic role in central nervous system diseases, liver diseases and digestive system cancer.

Objective: However, the role of carvacrol in osteosarcoma and its underlying molecular mechanism remain elusive.

Dichotic listening using Mandarin CV-words of six plosives and vowel /a/.

Objective: Available data on dichotic listening using tonal Chinese words have been limited, and conflicting results on a right-ear advantage (REA) have been reported. The current study developed a set of Mandarin CV-words based on the Bergen dichotic listening paradigm.

Design: The test materials consisted of two sets of stimuli.

Stress ulcer prophylaxis with proton pump inhibitors or histamine 2 receptor antagonists in critically ill adults - a meta-analysis of randomized controlled trials with trial sequential analysis.

Background: Proton pump inhibitors (PPI) and histamine 2 receptor antagonists (H2RA) have been widely used as stress ulcer prophylaxis (SUP) in critically ill patients, however, its efficacy and safety remain unclear. This study aimed to assess the effect of SUP on clinical outcomes in critically ill adults.

Methods: Literature search was conducted in PubMed, EMBASE, Web of Science, and the Cochrane database of clinical trials for randomized controlled trials (RCTs) that investigated SUP, with PPI or H2RA, versus placebo or no prophylaxis in critically ill patients from database inception through 1 June 2019.

Factors affecting the Mandarin dichotic digits test.

Data with regard to the Mandarin dichotic digits test (DDT) are limited, with conflicting results reported between the Mandarin and English DDTs. The current study examined factors that might affect the performance in the Mandarin DDT. The digits were arranged in 3 sets of 20 dichotic pairs; each set comprised 2, 3 or 4 digits in a pair.

Comparison of big funnel and individualized stents for management of stomach cancer with gastric outlet obstruction.

Background: Previous studies reported a similar rate of complications, including stent migration and obstruction, between individualized stents and the standard uncovered stents in gastric outlet obstruction (GOO) caused by distal stomach cancer. The objective of this study was to evaluate the efficacy and safety of funnel stents for management of GOO caused by distal stomach cancer.

Methods: This study was designed as a multicenter, controlled, prospective, and randomized clinical trial involving 4 hospitals.

Development of the Mandarin speech banana.

: For Indo-European languages, "speech banana" is widely used to verify the benefits of hearing aids and cochlear implants. As a standardised "Mandarin speech banana" is not available, clinicians in China typically use a non-Mandarin speech banana. However, as Chinese is logographic and tonal, using a non-Mandarin speech banana is inappropriate.

Transfection of the CagA gene alters MUC5AC expression in human gastric cancer cells.

, the primary causative agent of stomach cancer, is known to affect gastric mucin expression. However, the underlying molecular mechanisms mediating this -dependent effect remain unknown. In the present study, the effect of exogenous expression of the virulence factor, CagA, on mucin 5AC oligomeric muscus/gel-forming (MUC5AC) expression was investigated using an model of the gastric mucosa.

The anti-osteosarcoma cell activity by a mTORC1/2 dual inhibitor RES-529.

mTOR over-activation is important for human osteosarcoma (OS) tumorigenesis and progression. RES-529 is a mTORC1/2 dual inhibitor. Here, our results show that RES-529 inhibited viability, cell cycle progression and proliferation of the established (U2OS line) and primary human OS cells.

Central conduction time in auditory brainstem response and ear advantage in dichotic listening across menstrual cycle.

The ovarian hormones fluctuate during the menstrual cycle in women. Such fluctuation of sex hormones, in particular estrogen, is believed to affect the central conduction time in auditory function as well as the language lateralization in cognitive function. However, findings are inconsistent.

Effects of cisplatin on the auditory function of ovariectomized rats with estrogen deficiency.

Conclusion: The ovariectomy in rats does not change their auditory function. However, combining ovariectomy with Cisplatin treatment increases the risk of damaging the auditory function relative to the ototoxic effect caused by Cisplatin alone or ovariectomy alone.

Objectives: The auditory benefit from estrogen depends on a number of factors that make findings among studies controversial.

Effects of Noise Exposure on the Auditory Function of Ovariectomized Rats with Estrogen Deficiency.

Objective: The benefits of estrogen for the auditory function of women depend on a number of factors. In this study, we aimed to examine the impact of noise trauma on the auditory function of ovariectomized rats with estrogen deficiency.

Materials And Methods: Twenty-eight young, female Sprague-Dawley rats were assigned to three groups (OVX+N, OVX-N, Sham+N).