[Association of genetic polymorphism of XPD with chromosomal damage in workers exposed to radiation].

Objective: To explore association genetic polymorphism of XPD with chromosomal damage in workers exposed to radiation.

Methods: 182 workers exposed to radiation for at least one year with chromosomal damage were selected as cases based on a general health examination for all workers exposed to radiation in Tangshan city. The control group without chromosomal damage was matched to case by age (within 5 years), sex, work unit, type of exposed to radiation, cumulate serve length (within 1 year) according to 1:1.

[Relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury].

Objective: To explore the relationship between polymorphisms of DNA repair gene XRCC1 and susceptibility to radiation injury.

Methods: In 1:1 case-control study, 113 abnormal chromosome workers exposed to ionizing radiation were selected as cases and 113 normal chromosome as controls who matched with case for sex, age (+/- 5 years), nation, type of work, the same or more but in 2 years work length and the same similar levels of the cumulative exposure radiation dose. Genotypes were analysed using PCR based restriction fragment length polymorphism techniques.