Structural and energetic insight into the interactions between the benzolactam inhibitors and tumor marker HSP90α.

The heat shock protein 90α (HSP90α) provides a promising molecular target for cancer therapy. A series of novel benzolactam inhibitors exhibited distinct inhibitory activity for HSP90α. However, the structural basis for the impact of distinct R1 substituent groups of nine benzolactam inhibitors on HSP90α binding affinities remains unknown.

[Relationship between perceptions of safety climate at workplace and depressive disorders in manufacturing workers].

Objective: To investigate the risk factors for depressive disorders in manufacturing workers and to provide a basis for developing health promotion measures at workplace.

Methods: A questionnaire survey was performed in 8085 front-line production workers from 33 manufacturing enterprises in Nanhai District of Foshan, Guangdong Province, China. The questionnaire contained a survey of demographic characteristics, the Safety Climate Scale, the Center for Epidemiological Studies Depression Scale, etc.

[Associations of occupational safety atmosphere and behaviors with unintentional injuries].

Objective: To evaluate the associations of perception of safety atmosphere at workplace, occupational safety attitude and behaviors with occupational unintentional injury among manufacturing workers.

Methods: A cross-sectional study was performed and a self-administered questionnaire was used to inquire socio-demographic characteristics, perceived safety atmosphere, occupational safety attitudes, occupational safety behaviors and occupational unintentional injuries among 10585 manufacturing workers selected from 46 enterprises in Guangdong. Structural equation modeling was applied to assess the relationship of the perception of safety atmosphere at workplace, occupational safety attitude, and occupational safety behaviors with occupational unintentional injury.

[Near-infrared spectroscopy quantitative analysis model based on inverse regression].

In the present paper, an inverse regression method is used in near infrared (NIR) spectroscopy analysis to reduce dimension of predictor at first, then estimate linear regression function using the new derived low dimensional data. A real data set of 103 corn samples was used for analysis with this new inverse regression method. Taking 103 corn samples as experiment materials, seventy samples were chosen randomly to establish predicting model, the remaining thirty-three corn samples were viewed as prediction set.

[Near-infrared spectrum quantitative analysis model based on principal components selected by elastic net].

Elastic net is an improvement of the least-squares method by introducing in L1 and L2 penalties, and it has the advantages of the variable selection. The quantitative analysis model build by Elastic net can improve the prediction accuracy. Using 89 wheat samples as the experiment material, the spectrum principal components of the samples were selected by Elastic net.

[A retrospective study of clinical and pathological spectrum in 91 patients with chronic severe hepatitis B].

Objective: In China, liver failure is also termed as severe hepatitis in whom chronic severe hepatitis B (CSHB) is most common. The aim of this study was to assess whether CSHB based on different liver injury extent can meet the international definition of acute-on-chronic liver failure(ACLF)criteria, according by their clinical and pathological feature.

Methods: A total of 91 patients with CSHB were involved in the study.

[Effects of neurotrophin 3 on interdigestive migrating motor complex in rats with acute liver injury.].

Objective: To observe the effects of neurotrophin 3(NT-3)on interdigestive migrating motor complex (MMC) in rats with D-galactosamine induced acute liver injury.

Methods: Twenty-four specific pathogen-free purebred rats were equally randomized into control and acute liver injury groups. The control group was injected with equal volume of normal saline via tail vein.

[The changes of interdigestive migrating motor complex in rats with acute liver failure].

Objective: To observe the changes and characteristics of interdigestive migrating motor complex (MMC) in rat models of acute liver failure.

Methods: 30 rat models with acute liver failure were induced with D-galactosamine and another 30 normal rats were used as controls. The indexes of MMC recorded by multi-channel physiological recorder were compared.

[Study on the application of ridge regression to near-infrared spectroscopy quantitative analysis and optimum wavelength selection].

In the present paper, taking 66 wheat samples for testing materials, ridge regression technology in near-infrared (NIR) spectroscopy quantitative analysis was researched. The NIR-ridge regression model for determination of protein content was established by NIR spectral data of 44 wheat samples to predict the protein content of the other 22 samples. The average relative error was 0.

[Study on the application of supervised principal component regression procedure to near-infrared spectroscopy quantitative analysis].

The present paper introduces the principle of a new modeling method, called supervised principal component regression, with which the model of the near-infrared (NIR) spectroscopy quantitative analysis was established. Usually, there are many difficulties such as collinearity when establishing the quantitative analysis model for the high dimension of the spectral data. Using this new method, firstly according to some criterion, the wavelength information is selected in order to reduce the dimension of spectral data.

[Establishment of a D-galactosamine/lipopolysaccharide induced acute-on-chronic liver failure model in rats].

Objective: To establish a practical and reproducible animal model of human acute-on-chronic liver failure for further study of the pathophysiological mechanism of acute-on-chronic liver failure and for drug screening and evaluation in its treatment.

Methods: Immunological hepatic fibrosis was induced by human serum albumin in Wistar rats. In rats with early-stage cirrhosis (fibrosis stage IV), D-galactosamine and lipopolysaccharide were administered.

[Histopathological changes in livers of patients with chronic severe hepatitis B].

Objective: To investigate the histopathological features in livers of chronic severe hepatitis B (CSHB) patients.

Methods: Histology of 42 livers was studied. HE, Masson, Sweet and D-PAS staining and cytokeratin 7, CD68 and proliferating cell nuclear antigen immuno-histochemical staining were used in the study.

[Analysis on the multi-distribution and the major influencing factors on severe acute respiratory syndrome in Beijing].

Objective: To analyse the multi-dimension nature of severe acute respiratory syndrome (SARS) transmission.

Methods: Based on the data of SARS in 2003 and the geographic information system of Beijing, as well as under the broad range of the theorems and techniques of data-driven and model-driven knowledge mining, hierarchical techniques were used to test the hot spots. Wavelet technique was also used to decompose Moran's I frequency to survey the spatial clustering process of SARS.