Publications by authors named "Xu-cui Zhuang"
Objective: To investigate the feasibility of identifying the vulnerable plaque and predicting plague rupture and thrombus using by positron emission tomography/computed tomography angiography (PET/CTA).
Methods: Twenty-eight male New Zealand white rabbits were fed with hyper-lipid diet for 2 weeks before the balloon injury of the abdominal aorta.Then these rabbit were intermittently fed with hyper-lipid diet for 14 weeks, in order to trigger pharmaceutic the plague rupture and thrombus.
Background: Noninvasive detection of vulnerable plaque has a significant implication for prevention and treatment of atherosclerotic diseases. The aim of this study is to investigate the difference between vulnerable plaques and stable plaques in magnetic resonance (MR) images.
Methods: Atherosclerosis was induced in twenty male New Zealand white rabbits by high cholesterol diet and balloon injury of the abdominal aorta.
Article Synopsis
- The study investigates how well (18)F-FDG PET/CT imaging can differentiate between vulnerable and stable atherosclerotic plaques to help prevent cardiovascular events.
- In an experiment with 23 rabbits, researchers induced atherosclerosis and triggered thrombosis, measuring (18)F-FDG uptake in arterial plaques, which revealed significantly higher uptake in vulnerable plaques compared to stable ones.
- The results indicated the potential of using SUVmean values from PET scans to predict thrombosis events, showing promising sensitivity and specificity for assessing patient risk in atherosclerotic disease.