Overcoming chemotherapy resistance using pH-sensitive hollow MnO nanoshells that target the hypoxic tumor microenvironment of metastasized oral squamous cell carcinoma.

Background: Smart nanoscale drug delivery systems that target acidic tumor microenvironments (TME) could offer controlled release of drugs and modulate the hypoxic TME to enhance cancer therapy. The majority of previously reported MnO nanostructures are nanoparticles, nanosheets, or nanocomposites incorporated with other types of nanoparticles, which may not offer the most effective method for drug loading or for the controlled release of therapeutic payloads. Previous studies have designed MnO nanoshells that achieve tumor-specific and enhanced combination therapy for localized advanced cancer.

Changes of the condylar position after modified disk repositioning: A retrospective study based on magnetic resonance imaging.

Objective: This study aimed to explain the malocclusion resulting from the changes in condylar position after unilateral open disk repositioning surgery.

Study Design: Patients treated with unilaterally modified temporomandibular joint disk repositioning were reviewed. All patients underwent magnetic resonance imaging (MRI) before and immediately after surgery.

An innovative total temporomandibular joint prosthesis with customized design and 3D printing additive fabrication: a prospective clinical study.

Background: Total temporomandibular joint (TMJ) prosthesis is an effective and reliable method of joint reconstruction. However, there is still an urgent need to design a new TMJ prosthesis because of no commercially available TMJ prosthesis appropriate for the clinical application on the Chinese population. This study was introduced to prospectively confirm the safety and effectiveness of a new TMJ prosthesis with customized design and 3D printing additive fabrication in clinical application.