Publications by authors named "Xu-Yong Lin"

Article Synopsis
  • - Polymorphous low-grade adenocarcinomas (PACs) are low-risk malignant tumors of salivary glands that can sometimes exhibit more aggressive behavior, leading to them being classified as PACs by the World Health Organization.
  • - A case study reported a 58-year-old man who experienced unexplained fever, cough, and shortness of breath, leading to the discovery of a primary PAC in his lungs, which exhibited features like bronchial cartilage invasion and lymph node metastasis.
  • - After diagnosis through clinical and pathological evaluation, the patient underwent successful thoracoscopic resection of affected lung areas, highlighting the importance of accurate identification of PAC to avoid misdiagnosis in similar lung tumors.
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Rationale: Thymic adenocarcinoma is an extremely rare thymic carcinoma. The exact genetic alteration associated with thymic adenocarcinoma is unclear. Here, we report a case of thymic adenocarcinoma accompanied by type A thymoma and pulmonary minimally invasive adenocarcinoma (MIA).

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Article Synopsis
  • Yolk sac tumors in adults are extremely rare, with only six documented cases in the nasal cavity and paranasal sinuses, often linked to other cancers.
  • A case study of a 55-year-old man showed a nasal tumor with characteristics of pure YST, but further testing revealed a diagnosis of INI-1-deficient carcinoma with YST features.
  • The patient had surgery and radiotherapy, displaying no signs of recurrence at the 6-month follow-up, highlighting the diagnostic complexity of similar tumors in adults.
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Laryngeal tuberculosis (LTB) is highly contagious and can cause permanent laryngeal damage. Therefore, correctly identifying laryngoscopic LTB lesion locations, sizes, and morphologic features are essential for LTB diagnoses. This study aimed to explore the appearance and morphologic features of LTB and correlated these features with clinical symptoms.

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  • Immune reconstitution inflammatory syndrome (IRIS) can occur after starting antiretroviral treatment for HIV and can have serious consequences if not diagnosed and treated quickly.
  • A case study reported a 21-year-old man with HIV and pneumonia who developed worsening symptoms shortly after beginning treatment, leading to a diagnosis of IRIS via a minimally invasive procedure.
  • Radial endobronchial ultrasound (EBUS)-guided lung biopsy is highlighted as an effective method for the prompt identification of pneumonia associated with IRIS.
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Background: Emerging evidence indicates a regulatory role of long non-coding RNAs (lncRNAs) in the development of gastric cancer (GC), but the mechanisms underlying their function have remained largely unknown. Recent microarray-based expression profiling has led to the identification of a novel differentially expressed lncRNA, LINC00858, in GC. Subsequently, LINC00858 was found to be highly expressed in GC tissues and cells.

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The ankyrin repeat and KH domain‑containing 1 (ANKHD1) protein was recently reported to be a potential member of the Hippo signaling pathway. However, its role in human non‑small‑cell lung cancer (NSCLC) has not been extensively investigated. The aim of the present study was to examine the expression of ANKHD1 in primary human tissues and cells and determine whether it is correlated with the clinical characteristics of tumor growth.

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Hypoxia-exposed lung cancer-released exosomal microRNA-23a (miR-23a) has been shown to enhance angiogenesis as well as vascular permeability, contributing to the close correlation between exosomal miR-23a and tumorigenesis. The current study aimed to investigate whether gastric cancer (GC) cell-derived exosomal miR-23a could induce angiogenesis and to elucidate the potential mechanisms associated with the process. Differentially expressed miRNAs in GC were initially screened from the Gene Expression Omnibus database.

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Pleomorphic xanthoastrocytoma (PXA) is a relatively rare, low grade astrocytic tumor that usually affects children as well as young adults. The reported cases were predominantly located superficially in the temporal lobe. To our knowledge, so far only two cases of PXA occurring in lateral ventricle were reported in English literature.

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Article Synopsis
  • Deep benign fibrous histiocytoma (FH) is a rare tumor found in deep soft tissues, including the trachea, with a recurrence rate of around 20%.
  • Surgical removal is the typical treatment, but some patients hesitate due to fears of complications.
  • A case study highlights the success of using a hybrid knife (HK) in combination with argon plasma coagulation (APC) for effectively managing a recurring tracheal FH, showing promising results without relapse over a six-month follow-up.
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Rationale: Deep benign fibrous histiocytoma (BFH) is relatively rare in contrast to superficial BFH involving the skin. Moreover, it was extremely rare for deep BFH occurring in the solid organ. To our knowledge, so far, only one case of deep BFH of the kidney was reported in English literature.

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Rationale: Placental transmogrification of the lung is a very rare lesion which was characterized by the presence of papillae resembling placental villi. Its pathogenesis still remains unclear. Some authors think that this lesion is congenital and related to hamartoma, and others advocate it is secondary change after emphysema.

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Mammalian ste20-like kinase 1 (MST1) is a Ser/Thr kinase involved in cell proliferation, apoptosis, and embryonic development. MST1 is also an important member of the Hippo pathway which can regulate organ size and cell proliferation. Growing evidence indicates that MST1 influences cell proliferation through different pathways including Wnt, Akt, JNK, and Hippo pathways in different cells respectively.

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Rationale: Mucous gland adenoma is an extremely rare benign tumor predominately presented in central bronchus. Thus far, only six cases located in the periphery have been reported in English literature.

Patient Concerns: Herein, we report a case located in periphery of the lung with parenchymal involvement in a 59-year-old female.

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Rationale: Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare malignant nasopharyngeal tumor with features resembling papillary thyroid carcinoma including nuclear positive expression of thyroid transcription factor-1 (TTF-1).

Patient Concerns: A 64-year-old male presented with nasal bleeding and a foreign body sensation of the nasopharynx. Laryngoscopy revealed a 2.

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Rationale: Chondromyxoid fibroma (CMF) is a rare benign bone neoplasm which often occurs in the lower extremities. Little is known about the radiological and histological presentation of CMF in the sellar region.

Patient Concerns: A 16-year-old Asian male presented to the hospital 12 months ago with bilateral diplopia involving right visual fields, intermittent headaches, and dizziness.

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Inversin, encoded by NPHP2, is one of the 10 NPHP proteins known to be involved in nephronophthisis (an autosomal recessive cystic kidney). Although the previous reports showed that inversin played an important role in embryonic development and renal diseases, its function in cancer was not revealed clearly so far. As measured by immunohistochemical staining, inversin was highly expressed in the cytoplasm of lung cancer samples (63.

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Hemangioblastoma is a well-circumscribed, highly vascular, lipid-rich and low-grade tumor of uncertain histogenesis. Its histopathological features have been well established. Herein, we present a case of cerebellar hemangioblastoma in a 43-year-old woman.

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FBXO25 is a recently discovered protein that belongs to the Fbx class of the F-box family of proteins, and F-box proteins play a crucial role in tumorigenesis. However, the function of FBXO25 in cancer was not revealed so far. As measured by immunohistochemical staining, FBXO25 was highly expressed in the cytoplasm and nucleus of lung cancer samples (64.

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Glomus tumor is an uncommon tumor usually presenting in the dermis. Rarely, it occurred in visceral organs including stomach, liver and long. The majority of glomus tumors were benign.

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Background: Recent studies demonstrate that plant homeodomain finger protein 20 (PHF20), which was initially described as an immunogenic antigen in glioblastoma, is a putative transcriptional factor, and exhibits tumor suppressor activity. However, little is known about its expression and clinical significance in lung cancer.

Methods: We investigated the expression of PHF20 in 142 cases of NSCLC tissue and 30 cases of normal lung tissue by immunohistochemical staining and downregulated PHF20 expression in SPC cell.

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Pulmonary papillary adenoma is a very rare tumor usually presenting in periphery of the lung. Herein, we present a case of pulmonary papillary adenoma located in central portion of the lung in a 17 year-old Chinese female. A well-defined mass was incidentally detected at right pulmonary hilar region by imaging examination.

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