Publications by authors named "Xu-Yi Li"
Although bile acids play a notable role in depression, the pathological significance of the bile acid TGR5 membrane-type receptor in this disorder remains elusive. Using depression models of chronic social defeat stress and chronic restraint stress in male mice, we found that TGR5 in the lateral hypothalamic area (LHA) predominantly decreased in GABAergic neurons, the excitability of which increased in depressive-like mice. Upregulation of TGR5 or inhibition of GABAergic excitability in LHA markedly alleviated depressive-like behavior, whereas down-regulation of TGR5 or enhancement of GABAergic excitability facilitated stress-induced depressive-like behavior.
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- SSPC senescence, which hinders bone healing as we age, is linked to factors secreted by macrophages in bone calluses, particularly grancalcin (GCA).
- Injecting GCA into young mice triggered SSPC senescence and slowed down fracture healing, while removing the GCA gene from macrophages led to faster healing in older mice.
- The study suggests that targeting GCA could be a potential treatment for improving fracture healing in older individuals suffering from nonunion or delayed fractures.
Article Synopsis
- Type H vessels, a subtype of bone capillaries that express high levels of CD31 and endomucin, play a significant role in connecting bone growth (osteogenesis) and blood vessel formation (angiogenesis), but their numbers decrease with age.
- The study identifies microRNA-188-3p (miR-188-3p) as a key player in this decline, with higher levels in aged skeletal endothelium that inhibit type H vessel formation by targeting integrin β3.
- Mice lacking miR-188-3p showed improved preservation of type H vessels with age, while overexpressing it led to fewer type H vessels, lower bone mass, and slower bone healing, suggesting miR-
[Continuous-rain hazard of transplanting and direct-sowing rice in Sichuan Basin, China].
Ying Yong Sheng Tai Xue Bao
September 2021
Continuous rain disaster is a kind of complex disaster with high frequency in the Basin area of Sichuan Province. Continuous rainy weather may appear in every growing stage of rice, with consequences on the yield and quality. Based on the meteorological data of 105 meteorological stations between 1981 and 2019, combining the observation data of rise production, agricultural statistics and the basic geographic information, we quantitatively evaluated and compared the continuous-rain disasters in the whole growth period and the four growth stages (sowing-jointing, jointing-booting, booting-early filling, mid-late filling-maturity) between transplanted rice and direct-seeded rice in the basin area of Sichuan Province.
View Article and Find Full Text PDF[Correlation between adenoid hypertrophy, maxillary sinus mucosal thickening and dentofacial development in children].
Shanghai Kou Qiang Yi Xue
October 2019
PURPOSE：To investigate the effects of adenoid hypertrophy and maxillary sinus mucosal thickening on dentofacial development. METHODS：The selected subjects were divided into 4 groups according to the inclusion criteria: group A (adenoid hypertrophy with maxillary sinus mucosal thickening), group B (adenoid hypertrophy without maxillary sinus mucosal thickening), group C (normal adenoid with maxillary sinus mucosal thickening), and group D (normal adenoid without maxillary sinus mucosal thickening). There were 20 subjects in each group, aging from 12 to 14 years old.
View Article and Find Full Text PDFStatement Of Problem: A wide range of yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) ceramics have been applied for dental restorations. However, whether hydrothermal aging affects the surface roughness of Y-TZP is unknown.
Purpose: The purpose of this systematic review and meta-analysis was to evaluate the effects of low-temperature degradation (LTD) on the surface roughness of Y-TZP ceramics.
Helicid (4-formylphenyl-O-β-D-allopyranoside), an active component found in seeds from the Chinese herb Helicia nilagirica, has been reported to exert sedative, analgesic, hypnotic and antidepressant effects. The present study was designed to evaluate the antidepressant, learning and cognitive improvement effects of helicid in a chronic unpredictable mild stress (CUMS) model of depression in rats and to explore cAMP/protein kinase A (PKA)/cAMP response element-binding (CREB) signaling pathway. Sprague-Dawley rats were randomly assigned to six groups (n = 10): control; CUMS; CUMS + fluoxetine (5 mg/kg) and CUMS + helicid at 8, 16 and 32 mg/kg.
View Article and Find Full Text PDFObjective: Recently, several cohort studies suggested a positive relationship between serum uric acid (SUA) and type 2 diabetes mellitus (T2DM), which is inconsistent with the results of functional research. Our aim was to further evaluate this correlation by conducting a systematic review.
Methods: Computerized literature searches of the Medline database, EMBASE database, and PubMed were used to evaluate the relationship between SUA and T2DM in cohort studies.