MDA5-positive dermatomyositis without muscle weakness and rash: a case report and literature review.

Melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (DM) is a rare systemic autoimmune disease associated with a high rate of mortality attributable to rapidly progressive interstitial lung disease. MDA5-positive DM is often complicated by a typical rash and muscle weakness. Herein, we describe a 50-year-old woman who presented with worsening pulmonary symptoms with an absence of typical clinical characteristics.

[Internal carotid artery pseudoaneurysm caused by parapharyngeal abscess: A case report].

Pseudoaneurysms of the neck are seldom, and those caused by neck infections especially parapharyngeal abscess are even rarer. However, it is life-threatening and may bring sudden death due to the obstruction of airway and the pseudoaneurysms rupture. We analyzed the clinical features, diagnosis and treatment of the disease through a case summary and literature review in order to guide clinical diagnosis and treatment of pseudoaneurysms.

An integrated strategy combining network toxicology and feature-based molecular networking for exploring hepatotoxic constituents and mechanism of Epimedii Folium-induced hepatotoxicity in vitro.

Epimedii Folium (EF), a commonly used herbal medicine to treat osteoporosis, has caused serious concern due to potential hepatotoxicity. Until now, its intrinsic hepatotoxic mechanism and hepatotoxic ingredients remain unclear. Here, a novel high-throughput approach was designed to investigate the intrinsic hepatotoxic of EF.

Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics.

Background: Fritillariae Bulbus (FB) is widely used as a traditional medicine for the treatment of lung meridian diseases. It has been proved that FB has good anti-non-small cell lung cancer (NSCLC) activity. However, the active components and potential mechanism are still not clear.

Chemometrics integrated with in silico pharmacology to reveal antioxidative and anti-inflammatory markers of dandelion for its quality control.

Background: Dandelion is an herb with high nutritional and medicinal values, which has been listed in Chinese Pharmacopeia, European Pharmacopoeia and British Pharmacopoeia, gaining increasing acceptance around the world. However, the current quality control of dandelion is lagging behind. Only in Chinese Pharmacopeia, cichoric acid is used as a marker compound for its quality evaluation, whereas, it can not comprehensively reflect the bioactivity of dandelion.

Simultaneous Presentation of Multiple Myeloma and Lung Cancer: Case Report and Gene Bioinformatics Analysis.

Patients diagnosed with more than one cancer generally develop the individual tumors sequentially. There are a few cases of co-occurring multiple myeloma and lung cancer reported in the literature. Here, we report two cases of co-occurring multiple myeloma and lung cancer in patients who presented with the chief complaint of pain.

invasion syndrome: a case of liver abscess combined with lung abscess, endophthalmitis, and brain abscess.

invasion syndrome (KPIS) is a critical multi-site infection that is usually caused by highly virulent . It is relatively common in Asian patients with diabetes and leads to sepsis, which has a high mortality rate. We report the case of a man in his early 40s who presented to the hospital with blurred vision in his left eye of 7 days' duration and fever of 1 day's duration.

Treatment for CD57-negative γδ T-cell large granular lymphocytic leukemia with pure red cell aplasia: A case report.

Background: T-cell large granular lymphocytic leukemia (T-LGLL) is a rare type of aplastic anemia with diverse clinical manifestations. Concomitant diseases are often present at the first manifestation. We describe the treatment of a patient with CD57-negative γδT-LGLL with pure red cell aplasia (PRCA).

Brucellosis of unknown origin with haemophagocytic syndrome: A case report.

Background: Brucellosis is a contagious bacterial disease caused by species, which is a leading zoonotic disease worldwide. Most patients with brucellosis have a clear infection source; however, our case had a rare presentation of secondary haemophagocytic lymphohistiocytosis without any epidemiological history.

Case Summary: A 50-year-old man was admitted to our hospital with a fever of unknown origin.

infection secondary to spontaneous renal rupture that presents only as fever: A case report.

Background: Spontaneous renal rupture is a rare disease in the clinic. The causes of spontaneous renal rupture include extrarenal factors, intrarenal factors, and idiopathic factors. Reports on infection secondary to spontaneous renal rupture and the complications of spontaneous renal rupture are scarce.

Liquid chromatographic separation of alkaloids in herbal medicines: Current status and perspectives.

Alkaloids are a widespread group of basic compounds in herbal medicines and have attracted great interest due to various pharmaceutical activities and desirable druggability. Their distinctive structures make chromatographic separation fairly difficult. Peak tailing, poor resolution, and inferior column-to-column reproducibility are common obstacles to overcome.

[Evaluation and Comparison of Thromboelastography and Conventional Coagulation Tests for Blood Coagulation Function in Children with Henoch-Schönlein Purpura].

Objective: To investigate the efficacy of disease control, survival time and safely in treatment of newly diagnosed multiple mycloma patients with different dose of tenalidomide regimens.

Methods: The clinical data of 116 patients with multiple myeloma from June 2011 to June 2015 were collected and analyzed retrospectively. According to doses of used lenalidomide based on dexamethasone plus lenalidomide regimen 116 patients were divided into 2 groups: conventional dose group (58 cases) and low dose group (58 cases).

Myeloperoxidase polymorphism and coronary artery disease risk: A meta-analysis.

The myeloperoxidase (MPO) gene 463G/A and 129G/A polymorphisms have been reported to be associated with coronary artery disease (CAD), but the results remain inconclusive. This meta-analysis was designed to clarify these controversies.PubMed, EMBASE, and the Cochrane Library were used to retrieve the relevant literature up to March 2015 according to keywords.

A New Runge-Kutta Discontinuous Galerkin Method with Conservation Constraint to Improve CFL Condition for Solving Conservation Laws.

We present a new formulation of the Runge-Kutta discontinuous Galerkin (RKDG) method [9, 8, 7, 6] for solving conservation Laws with increased CFL numbers. The new formulation requires the computed RKDG solution in a cell to satisfy additional conservation constraint in adjacent cells and does not increase the complexity or change the compactness of the RKDG method. Numerical computations for solving one-dimensional and two-dimensional scalar and systems of nonlinear hyperbolic conservation laws are performed with approximate solutions represented by piecewise quadratic and cubic polynomials, respectively.

[Changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock].

Objective: To explore the changes and clinical significance of serum Apelin in patients with severe sepsis and septic shock.

Method: We measured the serum level of Apelin with ELISA on different observation days (the 1st, 3rd, and 10th day obtaining the diagnosis) in 26 patients with severe sepsis and septic shock.

Results: Serum Apelin significantly increased in sepsis patients when compared with the normal control group (P<0.

[Effects of costimulatory pathway OX40/OX40L on the pathogenesis of allergic asthma in mice].

Objective: Allergic asthma is thought to be mediated by CD4+ T lymphocytes producing the Th2-associated cytokines, which play a critical role in the development of the airway hyper-responsiveness and the eosinophilic inflammatory response. The costimulatory pathway CD28/B7 has been shown to play an important role in CD4+ T cell activation in allergic asthma. This study was conducted to evaluate the role of another costimulatory pathway OX40/OX40 ligand (L) in the pathogenesis of allergic asthma in BALB/c mice.

A multicentre, randomized, controlled trial of oseltamivir in the treatment of influenza in a high-risk Chinese population.

Objective: To evaluate the efficacy and safety of oseltamivir treatment in a population at high risk for influenza.

Research Design And Methods: This was a randomized, open-label, controlled trial involving Chinese patients with chronic respiratory diseases (chronic bronchitis, obstructive emphysema, bronchial asthma or bronchiectasis) or chronic cardiac disease. Patients showing symptoms of influenza were randomly assigned to receive oral oseltamivir 75 mg twice daily for 5 days (oseltamivir group), or symptomatic treatment (control group) within 48 h after symptom onset.

[Protective effect of protease inhibitor on renal function of rat challenged by lipopolysaccharide].

Objective: To investigate the protective effects of protease inhibitor on lipopolysaccharide (LPS)-induced kidney injury in rats and its possible mechanism.

Methods: Thirty-two male Wistar rats were divided into four groups randomly: normal control (n=6); LPS group (n=10), receiving intravenous endotoxin (LPS, O55:B5, 5 mg/kg); low-dose ulinastatin (UT) intervention group (n=8), receiving intraperitoneal UT 50 000 U/kg and LPS 5 mg/kg as above; high-dose UT intervention group (n=8), UT 100,000 U/kg and LPS 5 mg/kg. The following examinations were carried out: blood gas analysis, kidney pathological changes, plasma endothelin-1, plasma lactic acid, N-acetylglucosaminidase (NAG) in urine, and plasma creatinine (Cr) level.

[Inhibitory effects of protease inhibitor on endotoxin-induced acute lung injury in rats].

Objective: To investigate the effects of protease inhibitor on lipopolysaccharide-induced acute lung injury in rats and its possible mechanisms.

Methods: Thirty-two male Wister rats, weighting 250-270 g, were divided into four groups randomly. C, normal controls (n=8); A: acute lung injury group (n=8), receiving intravenous endotoxin (lipopolysaccharide O55:B5, LPS 5 mg/kg); V, low-dose group (n=8), U, high-dose intervention group (n=8, receiving Ulinastatin 50,000 U/kg and 100,000 U/kg respectively and LPS 5 mg/kg).

[MHC and its application in the population and conservation genetics].

The major histocompatibility complex (MHC),with the highest genetic polymorphism,is a cluster of genes involved in immune response regulation in the vertebrates.MHC can provide information such as population genetic diversity,evolutionary history and population dynamics,and population genetic structure etc. It can also be applied in the captive breeding programme for endangered vertebrate species.

[A multicenter randomized controlled study of the efficacy and safety of oseltamivir in the treatment of influenza in a high risk population].

Objective: To evaluate the efficacy and safety of oseltamivir in the treatment of influenza in a high risk population.

Methods: A randomized, open, control trial was conducted from Nov. 2002 to Feb.

[Clinical analysis of 5 cases with acute intravascular hemolysis caused by puerarin].

Objective: To explore the clinical characteristics of acute intravascular hemolysis caused by puerarin so as to help our prevention, diagnosis and treatment.

Methods: Analysis of 5 cases of acute intravascular hemolysis caused by puerarin was made and literature review conducted.

Results: All patients had the history of administering puerarin, with the pre-symptoms of acute hemolysis; the clinical characteristics of acute intravascular hemolysis were observed:sudden attacks of lumber and abdominal pain, chill, fever dyspnea, temporary conciousness loss, dark urine or hematuria, low hemoglobin, high reticular red blood cell, positive of Coombs' test.