Publications by authors named "Xu-Wang Pan"

Globally, liver cancer ranks among the most lethal cancers, with chemotherapy being one of its primary treatments. However, poor selectivity, systemic toxicity, a narrow treatment window, low response rate and multidrug resistance limit its clinical application. Liver-targeted nanoparticles (NPs) exhibit excellent targeted delivery ability and promising effectivity in treating liver cancer.

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A series of novel 3-(thiophen-2-ylthio)pyridine derivatives as insulin-like growth factor 1 receptor (IGF-1R) inhibitors was designed and synthesized. IGF-1R kinase inhibitory activities and cytotoxicities against HepG2 and WSU-DLCL2 cell lines were tested. For all of these compounds, potent cancer cell proliferation inhibitory activities were observed, but not through the inhibition of IGR-1R.

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Article Synopsis
  • This study explores how to create artesunate polylactic acid (PLA) microspheres for use in hepatic arterial embolization and examines their drug release behavior.
  • The researchers used a method involving O/W emulsion and solvent evaporation, optimizing factors like PLA concentration and stirring speed through experiments.
  • They determined the best preparation conditions, resulting in microspheres with a size of about 101.7 micrometers, a drug loading capacity of 30.8%, and an entrapment rate of 53.6%, indicating a reliable and effective process for further research.
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