Publications by authors named "Xu-Ran Zhao"
Article Synopsis
- The study looked at how the number of white blood cells (lymphocytes) in breast cancer patients might affect their chances of surviving after surgery and radiation treatment.
- Researchers found that many patients had a drop in lymphocyte counts during treatment, but it was mostly not too severe.
- Lower lymphocyte counts before treatment were linked to lower survival rates, suggesting that checking these counts could help doctors understand a patient's prognosis better.
To investigate the dosimetric advantages of the voluntary deep inspiration breath-hold technique assisted by optical surface monitoring system for whole breast irradiation in left breast cancer after breast-conserving surgery and verify the reproducibility and acceptability of this technique. Twenty patients with left breast cancer receiving whole breast irradiation after breast-conserving surgery were enrolled in this prospective phase II study. Computed tomography simulation was performed during both free breathing and voluntary deep inspiration breath-hold for all patients.
View Article and Find Full Text PDFPurpose: The aim of this study is to evaluate the role of regional nodal irradiation (RNI) in patients with T1-2N1M0 breast cancer and to identify the subgroup that could benefit from RNI.
Methods And Materials: A total of 4,243 women with pT1-2N1M0 breast cancer treated at two institutions in China were retrospectively reviewed. Survival rates were calculated by the Kaplan-Meier method and compared by the log-rank test.
Radiation-Induced Hypothyroidism in Patients With Breast Cancer After Hypofractionated Radiation Therapy: A Prospective Cohort Study.
Int J Radiat Oncol Biol Phys
January 2023
Purpose: Our objective was to assess the incidence and risk factors of radiation-induced hypothyroidism (RHT) after adjuvant hypofractionated radiation therapy (RT) in patients with breast cancer.
Methods And Materials: Eligible patients with breast cancer who were treated with hypofractionated RT were prospectively evaluated. Thyroid function tests were performed before and at regular times after RT.
Article Synopsis
- The study aimed to evaluate how age affects the prognosis of patients with pT1-2N1 breast cancer and its role in the decision to administer postmastectomy radiotherapy (PMRT).
- A total of 5,438 patients were analyzed using advanced statistical methods to correlate age with treatment outcomes over a median follow-up period of 67 months.
- Findings indicated that while younger patients (≤50 years) benefitted from PMRT in terms of reducing relapse and improving survival, older patients (>50 years) did not show the same benefits, revealing age as a crucial factor in treatment decisions.
Purpose: To investigate the appropriate timing of radiotherapy (RT) after mastectomy and adjuvant chemotherapy for women with high-risk breast cancer.
Patients And Methods: Post hoc analyses of 584 patients with stage II and III breast cancer from a randomised controlled clinical trial were performed. All patients underwent mastectomy followed by sequential chemotherapy and RT.
Purpose: To map the locations of level I axilla (Ax-L1) lymph nodes (LNs), evaluate the clinical target volume (CTV) coverage defined by the Radiation Therapy Oncology Group (RTOG) Breast Cancer Atlas, and assess the optimal techniques for whole-breast and Ax-L1 irradiation (WBI + Ax-L1).
Methods And Materials: We identified 76 patients newly diagnosed with breast cancer with 1 to 4 positive LNs confirmed by axillary dissection. The locations of 116 involved Ax-L1 LNs on diagnostic computed tomography (CT) were mapped onto simulated CT images of a standard patient.
Objective: To clarify the effect of postmastectomy radiotherapy (PMRT) on pTN breast cancer patients with different molecular subtypes.
Methods: We retrospectively analyzed the data of 5442 patients with pTN breast cancer treated using modified radical mastectomy in 11 hospitals in China. Univariate, multivariate, and propensity score matching (PSM) analyses were used to evaluate the effect of PMRT on locoregional recurrence (LRR).
Background: Various randomized trials have demonstrated that postmastectomy radiotherapy (RT) to the chest wall and comprehensive regional nodal areas improves survival in patients with axillary node-positive breast cancer. Controversy exists as to whether the internal mammary node (IMN) region is an essential component of regional nodal irradiation. Available data on the survival benefit of IMN irradiation (IMNI) are conflicting.
View Article and Find Full Text PDFArticle Synopsis
- The study explores optimal radiation treatment for breast cancer patients experiencing their first chest wall recurrence after mastectomy.
- It analyzes the recurrence patterns and evaluates the effectiveness of adding regional nodal irradiation (RNI) to radiation therapy.
- Results suggest that combining chest wall treatment with RNI significantly improves progression-free and overall survival, especially in patients with a recurrence interval of 4 years or less.
Background And Purpose: We investigated the locoregional effect of trastuzumab, and determined whether patients with human epidermal growth factor receptor (HER)2-positive breast cancer (BC) treated with trastuzumab could achieve comparable efficacy to that of patients with HER2-negative BC.
Materials And Methods: This was analyses of data of 793 BC patients from a randomized controlled trial comparing post-mastectomy hypofractionated radiotherapy with conventional fractionated radiotherapy. Survival rates were analyzed by the Kaplan-Meier method and compared by the log-rank test.
Background: To compare the survival outcomes between breast-conserving surgery (BCS) and modified radical mastectomy (MRM), and to investigate the role of radiotherapy (RT) in patients with pT1-2N1M0 breast cancer.
Methods: A total of 4262 women with T1-2N1M0 breast cancer treated at two institutions were retrospectively reviewed. A total of 3858 patients underwent MRM, and 832 (21.
Purpose: To investigate the effect of chemotherapy and radiotherapy timing after breast conserving surgery (BCS) on recurrence and survival of women with early-stage breast cancer.
Patients And Methods: We retrospectively analyzed 900 patients who underwent BCS followed by both adjuvant chemotherapy and radiotherapy. Of these, 488 women received chemotherapy first (CT-first group) while the other 412 received radiotherapy first (RT-first group).
Purpose: The aim of this study was to determine whether radiation-induced lymphopenia affects the survival of patients with breast cancer.
Methods And Materials: Post hoc analysis was conducted on data from 598 patients with breast cancer from a randomized controlled trial comparing postmastectomy hypofractionated radiation therapy (HFRT; 43.5 Gy in 15 fractions over 3 weeks) with conventional fractionated radiation therapy (CFRT; 50 Gy in 25 fractions over 5 weeks).