MiR-25 suppresses 3T3-L1 adipogenesis by directly targeting KLF4 and C/EBPα.

In the past decade, miRNA emerges as a vital player in orchestrating gene regulation and maintaining cellular homeostasis. It is well documented that miRNA influences a variety of biological events, including embryogenesis, cell fate decision, and cellular differentiation. Adipogenesis is an organized process of cellular differentiation by which pre-adipocytes differentiate towards mature adipocytes.

Effects of 3-aminobenzamide on ventricular function in infarct heart assessed by quantitative tissue velocity imaging.

Background: Coronary artery disease is a common cardiovascular disease that often causes myocardial infarction (MI), which, after a certain period, can develop into congestive heart failure, resulting in high mortality and mortality rates. Overactivation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) has recently been considered a final common effector in myocardial ischemia/reperfusion injury. The aim of this study was to have a comprehensive understanding of the beneficial effects of 3-aminobenzamide (3-AB) on postinfarct myocardial injuries by inhibiting PARP.