Publications by authors named "Xu-Meng Wang"
Article Synopsis
- Chronic exposure to low-dose cadmium (Cd) is linked to the development of nonalcoholic steatohepatitis (NASH) in mice, causing increased fat deposition, hepatocyte destruction, and inflammation in the liver.
- The study introduced a murine model, where drinking water with Cd significantly affected liver health over 6 to 12 weeks, supporting the idea that Cd can promote NASH.
- The research also found that Cd disrupts fatty acid metabolism, particularly by inhibiting the desaturation process, leading to toxic saturated fatty acids that worsen liver damage and inflammation.
Nearly 70% of breast cancer (BC) is hormone-receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, and endocrine therapy is the mainstay of treatment for this subtype. However, intrinsic or acquired endocrine resistance can occur during the endocrine treatment. Based on insights of endocrine resistance mechanisms, a number of targeted therapies have been and continue to be developed.
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