Publications by authors named "Xu-Hui Wen"
Article Synopsis
- - The study evaluates the effectiveness of pleural fluid complement C1q for diagnosing tuberculous pleural effusion (TPE) specifically in elderly patients, as previous research primarily focused on younger individuals.
- - Researchers analyzed pleural fluid samples from patients with undiagnosed pleural effusions, finding that elderly TPE patients had higher C1q levels compared to those without TPE.
- - The results indicated that C1q has low diagnostic accuracy for TPE in older adults, with a sensitivity of 44% and specificity of 79% at a threshold of 100 mg/L.
The gut microbiota modulates response to hormonal treatments in prostate cancer (PCa) patients, but whether it influences PCa progression remains unknown. Here, we show a reduction in fecal microbiota alpha-diversity correlating with increase tumour burden in two distinct groups of hormonotherapy naïve PCa patients and three murine PCa models. Fecal microbiota transplantation (FMT) from patients with high PCa volume is sufficient to stimulate the growth of mouse PCa revealing the existence of a gut microbiome-cancer crosstalk.
View Article and Find Full Text PDFBackground: High prostate eicosapentaenoic fatty acid (EPA) levels were associated with a significant reduction of upgrading to grade group (GG) ≥ 2 prostate cancer in men under active surveillance. We aimed to evaluate the effect of MAG-EPA long-chain omega-3 fatty acid dietary supplement on prostate cancer proliferation.
Methods: A phase II double-blind randomized placebo-controlled trial was conducted in 130 men diagnosed with GG ≥ 2 prostate cancer and undergoing radical prostatectomy between 2015-2017 (Clinicaltrials.
Background: The diagnosis of tuberculous pleural effusion (TPE) is challenging for pulmonologists. Adenosine deaminase (ADA), interferon-gamma (IFN-γ), and interleukin-27 (IL-27) have some limitations for diagnosing TPE. Soluble Fas ligand (sFasL) had a high diagnostic value for TPE.
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- Lung cancer is the leading cause of malignant pleural effusion (MPE), and serum HE4 is a promising diagnostic marker.
- The study assessed the diagnostic accuracy of pleural fluid HE4 in patients with undiagnosed pleural effusion across two cohorts, using a double-blind, prospective design.
- Results showed that pleural fluid HE4 levels were significantly higher in MPE compared to benign effusions, with moderate sensitivity and high specificity, indicating its potential clinical utility in diagnosing MPE.
Background: Insulin-like growth factor (IGF) binding proteins (IGFBPs) are involved in tumorigenesis and cancer progression. IGFBP7 has been shown to act as either a tumor suppressive gene or an oncogene in many tumors, including stomach adenocarcinoma (STAD). To provide a more systematic and comprehensive understanding of IGFBP7 gene, we performed an integrative pan-cancer analysis and explored further with the case of STAD.
View Article and Find Full Text PDFBackground: The optimal multimorbidity measures for predicting disability trajectories are not universally agreed upon. We developed a multimorbidity index among middle-aged and older community-dwelling Chinese adults and compare its predictive ability of disability trajectories with other multimorbidity measures.
Methods: This study included 17,649 participants aged ≥50 years from the China Health and Retirement Longitudinal Survey 2011-2018.
Article Synopsis
- - Diagnosing tuberculous pleural effusion (TPE) is difficult due to the limitations of traditional methods like pleural fluid staining, culture, and biopsy, which can be invasive and time-consuming.
- - Nucleic acid amplification tests (NAAT) offer a quicker and less invasive alternative for TPE diagnosis.
- - This review discusses the accuracy of various NAATs for TPE, highlighting findings from systematic reviews and meta-analyses on tests such as GeneXpert and loop-mediated isothermal amplification.
Background: The in vitro stability assessment is essential for investigating the diagnostic accuracy of pleural biomarkers. This study aimed to investigate the long-term stability of pleural fluid carcinoembryonic antigen (CEA) at -80°C to -70°C. In addition, we analyzed the effects of frozen storage on the diagnostic accuracy of CEA for malignant pleural effusion (MPE).
View Article and Find Full Text PDFUnlabelled: Inadequate clinical preparation for palliative care is often reflected in inadequate education about death. Nursing students as nurses of the future, it is necessary to make them aware of death and overcome fear of it so that they can cope with their future careers and provide qualified and warmly care service.
Objectives: To determine the effect of death education course using constructivist learning theory on first grade undergraduate nursing student attitudes and coping abilities towards death.
Background: Tumor-associated macrophages (TAMs) affects the outcomes of non-small cell lung cancer (NSCLC). NSCLC cells released exosomes to suppress the antitumor activity of TAMs. MiR-146a is a critical regulator in TAM polarization.
View Article and Find Full Text PDFThere is increasing evidence that hexokinase is involved in cell proliferation and migration. However, the function of the hexokinase domain containing protein-1 (HKDC1) in gastric cancer (GC) remains unclear. Immunohistochemistry analysis and big data mining were used to evaluate the correlation between HKDC1 expression and clinical features in GC.
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- Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a dangerous bacterium that causes severe infections in both healthcare and community settings, posing significant public health risks.
- The evolution of CR-hvKP involves complex mechanisms, including the transfer of plasmids that carry genes for both hypervirulence and carbapenem resistance.
- This review discusses these evolutionary processes and highlights the current prevalence of CR-hvKP in the population.
Background And Aim: Capsule endoscopy (CE) has been used in clinical examination among people of various ages, while few studies exclusively focused on the young. We aimed to explore its clinical features in young adults and those with obscure gastrointestinal bleeding (OGIB).
Methods: A total of 479 young adults aged 18-44 years were analyzed, with median age of 33 years.
Background: The characteristics of nursing work determine that nursing practice is inseparable from ethical considerations and decision-making. Nursing students have difficulty in dealing with death and it is necessary to explore the ethical challenges faced by nursing undergraduates in the process of clinical practice of nursing dead or dying patients.
Objective: To explore the ethical challenges faced by undergraduate nursing students in nursing of dead or dying patients.
Objective: To assess the accuracy of pleural fluid homocysteine for discriminating malignant pleural effusion (MPE) and benign pleural effusion (BPE).
Methods: A total of 194 patients from two cohorts (Hohhot and Changshu) with undiagnosed pleural effusion were prospectively enrolled. Their pleural homocysteine was measured, and its diagnostic accuracy and net benefit for MPE were analyzed by receiver operating characteristic (ROC) curve analysis and decision curve analysis, respectively.
Diagnostic utility of pleural cell-free nucleic acids in undiagnosed pleural effusions.
Clin Chem Lab Med
September 2022
Pleural effusion (PE) is a common sign caused by various disorders. Microbiology, histology and cytology are reference standards for these disorders. However, these diagnostic tools have limitations, including invasiveness, high cost, long turnaround time, and observer-dependent.
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- This study focused on how different ways of measuring multimorbidity affect mortality rates in older Chinese adults.
- Data was collected from over 13,000 participants aged 65 and older between 2002 and 2018, analyzing factors like condition counts and patterns.
- It was found that those with multimorbidity had a higher risk of death, and trajectory-based measures were more effective for predicting mortality than simpler count or pattern measures.
Article Synopsis
- Diabetic cardiomyopathy (DCM) involves lipid buildup, mitochondrial problems, and inflammation, with mitochondrial DNA (mtDNA) playing a potential role in inflammation through the cGAS-STING pathway.
- The study identified increased levels of cytosolic mtDNA and the activation of this pathway in a mouse model of obesity-related DCM, linking it to inflammatory markers.
- Findings suggest that targeting the cGAS-STING pathway could provide a new therapeutic approach to treat DCM, as inhibiting this pathway reduced inflammation and cell death in heart cells.
Article Synopsis
- * Data from 18,002 participants indicated that 24.5% had multiple CMDs, and those with more CMDs generally experienced higher depressive symptoms, especially if they had specific conditions like stroke or diabetes.
- * The research suggests the need for personalized mental health care strategies for older adults with these conditions, focusing on both individual CMDs and their combinations to improve treatment outcomes.
Background: Accurate staging plays a pivotal role in cancer care. The lymph node (LN) ratio (LNR) and the log odds of positive LNs (LODDS) have been suggested as alternatives to the N staging since the TNM system has the risk of stage migration. The prognostic significance of LNR and LODDS in young patients with gastric cancer (GC) has not been reported.
View Article and Find Full Text PDFIntrinsic resistance to CDK4/6 inhibitors hinders their clinical utility in cancer treatment. Furthermore, the predictive markers of CDK4/6 inhibitors in gastric cancer (GC) remain incompletely described. Here, we found that PAX6 expression was negatively correlated with the response to palbociclib in vitro and in vivo in GC.
View Article and Find Full Text PDFAim: To explore whether self-efficacy has any positive or negative mediating effects between family functioning and quality of life among elders with chronic diseases.
Design: A cross-sectional study.
Methods: Questionnaires were collected from 516 community-dwelling elderly individuals with chronic diseases using a convenience sampling method.
HOX transcript antisense intergenic RNA (HOTAIR) is a lncRNA with a length of 2,158 nucleotides and its two terminal domains could combine with different complexes to function at the level of transcription and translation. It overexpresses in many cancers including gastric cancer. HOTAIR could play an oncogenic role in the initiation and progression of gastric cancer through interaction with microRNAs, such as miR-330/618/126 in the PI3K/Akt signaling pathways.
View Article and Find Full Text PDFBackground: Systemic inflammation and interactions with host-tumor are currently identified as a hallmark of cancer. The purpose of this study was to assess the prognostic value of preoperative modified Glasgow Prognostic Score (mGPS), systemic inflammation score (SIS) and "lymphocyte C-reactive protein score" (LCS) in gastric cancer (GC) patients.
Methods: 358 GC patients were enrolled in this retrospective study.