Publications by authors named "Xu-Hui Guo"
Tamoxifen-resistant breast cancer cells possess cancer stem-like cell properties.
Chin Med J (Engl)
August 2013
Background: Cancer stem cells (CSCs) are the cause of cancer recurrence because they are resistant to conventional therapy and contribute to cancer growth and metastasis. Endocrinotherapy is the most common breast cancer therapy and acquired tamoxifen (TAM) resistance is the main reason for endocrinotherapy failure during such therapy. Although acquired resistance to endocrine treatment has been extensively studied, the underlying mechanisms are unclear.
View Article and Find Full Text PDFBioinformatics analysis of breast cancer bone metastasis related gene-CXCR4.
Asian Pac J Trop Med
September 2013
Article Synopsis
- This study aimed to investigate the role of the gene CXCR4 in breast cancer bone metastasis using high-flux gene chip screening.
- The results showed that out of 396 genes analyzed, CXCR4 was significantly up-regulated in tissues with bone metastasis compared to those without, indicating its crucial involvement in this process.
- The findings suggest that bioinformatics analysis of CXCR4 could help in understanding, diagnosing, and developing targeted gene therapies for breast cancer bone metastasis, as well as predicting patient prognosis.
[Effects of high glucose on in vitro invasiveness of human breast cancer cell line MDA-MB-435].
Zhonghua Yi Xue Za Zhi
January 2013
Article Synopsis
- * Results show that as glucose concentration increases (from 5.5 to 25 mmol/L), the number of invasive cancer cells also rises significantly, along with increased expression of certain proteins (MMP-9/MMP-2) and decreased expression of E-cadherin.
- * The findings suggest that high glucose levels enhance the invasiveness of breast cancer cells by altering the expression of key proteins involved in cell movement and adhesion.