Publications by authors named "Xu-Hua Mao"
Article Synopsis
- Gastric cancer (GC) is a common and serious digestive tract tumor, with risk factors including age, high salt intake, low fruit and vegetable consumption, and infections, particularly with a specific pathogen.
- The infection can alter gastric epithelial cell behavior by activating carcinogenic pathways and causing changes in gene expression, though the exact mechanisms of these changes remain unclear.
- This review explores the virulence factors of the pathogen, their impact on various signaling pathways (like NF-κB, MAPK, JAK/STAT), and discusses potential new immunotherapy approaches for treating gastric cancer.
This study aims to explore the effects of microRNA-21 (miR-21) and ERK/NF-κB signaling pathway on human melanoma A375 cells. The melanoma tissues and adjacent normal tissues were obtained from 45 melanoma patients. qRT-PCR was conducted to quantify the expression of miR-21 and the gene mRNA expressions.
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- - Nogo protein, encoded by the reticulon-4 gene (RTN4), has three key isoforms (Nogo-A, Nogo-B, Nogo-C) and plays a role in cell apoptosis, particularly in tumor cells.
- - A specific polymorphism (rs34917480) in RTN4's 3'-UTR is linked to increased cancer susceptibility, prompting a case-control study with 411 NSCLC patients and 471 healthy controls.
- - Findings showed that the deletion allele of this polymorphism significantly raises NSCLC risk, especially in individuals over 60, males, and smokers, suggesting age, sex, and environmental factors also influence cancer risk.